Aggregation-Induced Emission Properties of Atypical Aliphatic-Chain-Linked Siloxanes-Containing Phosphonate Esters.

Phosphonate compounds have been proposed as atypical chromophores, but their luminescence properties, especially in combination with flexible aliphatic chains, remain underexplored. In this study, we have synthesized a series of novel siloxane-containing phosphonate esters as organofluorophores through a catalyst-free, one-pot Kabachnik-Fields (K-F) reaction. This reaction involved acetone, cyclohexanone, or cyclopentanone, with siloxanes containing aliphatic amines and phosphonate diesters as reactants.

Spatial transcriptomic analysis deciphers adipocyte-to-fibroblast transformation in bleomycin-induced murine skin fibrosis.

Background: Scleroderma is characterized by inflammation and fibrosis, predominantly occurring in the skin and extending to various parts of the body. The pathophysiology of scleroderma is multifaceted, with the current understanding including endothelial damage, inflammatory cell infiltration, and fibroblast activation in its progression. Nonetheless, the mechanism of cellular interactions and the precise spatial distribution of these cellular events within the fibrotic tissues remain elusive, highlighting a critical gap in our comprehensive understanding of scleroderma's pathogenesis.

In-situ nanoplatform with synergistic neutrophil intervention and chemotherapy to prevent postoperative tumor recurrence and metastasis.

In addition to residual tumor cells, surgery-induced inflammation significantly contributes to tumor recurrence and metastasis by recruiting polymorphonuclear neutrophils (PMNs) and promoting their involvement in tumor cell proliferation, invasion and immune evasion. Efficiently eliminating residual tumor cells while concurrently intervening in PMN function represents a promising approach for enhanced postoperative cancer treatment. Here, a chitosan/polyethylene oxide electrospun fibrous scaffold co-delivering celecoxib (CEL) and doxorubicin-loaded tumor cell-derived microparticles (DOX-MPs) is developed for postoperative in-situ treatment in breast cancer.

Soil phosphorus cycling microbial functional genes of monoculture and mixed plantations of native tree species in subtropical China.

Background: Transforming coniferous plantation into broadleaved or mixed broadleaved-coniferous plantations is the tendency of forest management strategies in subtropical China. However, the effects of this conversion on soil phosphorus (P) cycling microbial functional genes are still unknown.

Methods: Soil samples were collected from 0-20, 20-40, and 40-60 cm (topsoil, middle layer, and subsoil, respectively) under coniferous (PM), broadleaved (EF), and their mixed (PM/EF) plantation in subtropical China.

Isolation of the Stromal Vascular Fraction Using a New Protocol with All Clinical-Grade Drugs: From Basic Study to Clinical Application.

Objective: The purpose of this study was to evaluate the yield, viability, clinical safety, and efficacy of the stromal vascular fraction (SVF) separated with a new protocol with all clinical-grade drugs.

Materials And Methods: SVF cells were isolated from lipoaspirate obtained from 13 participants aged from 30 to 56 years by using a new clinical protocol and the laboratory protocol. The cell yield, viability, morphology, mesenchymal stem cell (MSC) surface marker expression, and differentiation abilities of the SVF cells harvested from the two protocols were compared.

Mechanical stretch preconditioned adipose-derived stem cells elicit polarization of anti-inflammatory M2-like macrophages and improve chronic wound healing.

Transplantation of adipose-derived stem cells (ASCs) is a promising option in the field of chronic wounds treatment. However, the effectiveness of ASCs therapies has been hampered by highly inflammatory environment in chronic wound areas. These problems could be partially circumvented using efficient approaches that boost the survival and anti-inflammatory capacity of transplanted ASCs.

Engineered Probiotic-Based Personalized Cancer Vaccine Potentiates Antitumor Immunity through Initiating Trained Immunity.

Cancer vaccines hold great potential for clinical cancer treatment by eliciting T cell-mediated immunity. However, the limited numbers of antigen-presenting cells (APCs) at the injection sites, the insufficient tumor antigen phagocytosis by APCs, and the presence of a strong tumor immunosuppressive microenvironment severely compromise the efficacy of cancer vaccines. Trained innate immunity may promote tumor antigen-specific adaptive immunity.

An Unprecedented CeO/C Non-Noble Metal Electrocatalyst for Direct Ascorbic Acid Fuel Cells.

Direct ascorbic acid fuel cells (DAAFCs) employ biocompatible ascorbic acid (AA) as fuel, allowing convenient storage, transportation, and fueling as well as avoiding fuel crossover. The AA oxidation reaction (AAOR) largely governs the performance of DAAFCs. However, AAOR electrocatalysts currently have low activity, and state-of-the-art ones are limited to carbon black.

Can industrial collaborative agglomeration improve carbon emission efficiency? Empirical evidence from China.

Against the backdrop of low-carbon development, it is imperative to cultivate a modernized industrial system and new development model. Industrial collaborative agglomeration (ICA) between manufacturing and producer services may offer an opportunity to aid carbon reduction in this scenario. Using balanced panel data of China's 30 provinces and municipalities from 2008 to 2019, this paper attempts to investigate the influences of ICA on carbon emission efficiency (CEE), its heterogeneous effects, impact mechanisms, and spillover effects.

 F.Wen & J.Q.Qin (Gesneriaceae), a new species from Yunnan Province, China.

F.Wen & J.Q.

Nanosized Proton Conductor Array with High Specific Surface Area Improves Fuel Cell Performance at Low Pt Loading.

The use of ordered catalyst layers, based on micro-/nanostructured arrays such as the ordered Nafion array, has demonstrated great potential in reducing catalyst loading and improving fuel cell performance. However, the size (diameter) of the basic unit of the most existing ordered Nafion arrays, such as Nafion pillar or cone, is typically limited to micron or submicron sizes. Such small sizes only provide a limited number of proton transfer channels and a small specific area for catalyst loading.

Ultrathin Ultralow-Platinum Catalyst Coated Membrane for Proton Exchange Membrane Fuel Cells.

Catalyst coated membrane (CCM) is the core component of proton exchange membrane fuel cells and is routinely fabricated by spraying Pt/C slurries onto membrane, resulting in low activity and thick catalyst layer (CL, 5-10 µm) with an unaffordable Pt loading of 0.2-0.4 mg cm and a large mass transfer resistance at cathode.

Research topics and hotspot trends of lumbar spondylolisthesis: A text-mining study with machine learning.

Objectives: The study aimed to conduct a bibliometric analysis of publications concerning lumbar spondylolisthesis, as well as summarize its research topics and hotspot trends with machine-learning based text mining.

Methods: The data were extracted from the Web of Science Core Collection (WoSCC) database and then analyzed in Rstudio1.3.

Deterministic and Probabilistic Health Risk Assessment of Toxic Metals in the Daily Diets of Residents in Industrial Regions of Northern Ningxia, China.

This study was designed to investigate the toxic metal (aluminum (Al), arsenic (As), chromium (Cr), cadmium (Cd), copper (Cu), nickel (Ni), lead (Pb), and zinc (Zn)) concentrations in drinking water and different foodstuffs meat (pork, beef, and mutton), cereals (rice, flour, corn, millet), beans (cowpeas, tofu), potatoes (potato, sweet potato), solanaceous fruits (pepper, eggplant, bitter gourd, cucumber), vegetables (cabbage, cauliflower, spinach), and fruits (apples, watermelons, pears, grapes)) and then estimate the potential health risks of toxic metal consumption to local residents in industrial regions of northern Ningxia, China. As in drinking water, Cr in meat, Pb in cereals, Pb in beans, As and Pb in potatoes, Pb in solanaceous fruits, Cr and Ni in vegetables, and Ni and Pb in fruits were the most contaminated heavy metals in the corresponding food with over-standard rates of 16.7%, 12.

Machine Learning Predict Survivals of Spinal and Pelvic Ewing's Sarcoma with the SEER Database.

Study Design: Retrospective Cohort Study.

Objectives: This study aimed to develop survival prediction models for spinal Ewing's sarcoma (EWS) based on machine learning (ML).

Methods: We extracted the SEER registry's clinical data of EWS diagnosed between 1975 and 2016.

Ultrafine IrRu Nanoparticles toward Efficient Oxygen Evolution Reaction in Acidic Media.

Proton exchange membrane water electrolyzers (PEMWEs) are capable of mass-producing green hydrogen with renewable and wave-trough electricity, but confront the challenge of the lack of advanced electrocatalysts to accelerate sluggish oxygen evolution reaction (OER). Herein, we report the synthesis of ultrafine IrRu alloy nanoparticles (1.6 ± 0.

New insight into the mechanism of Pt(0)-catalyzed hydrosilylation reaction of (CH)SiH with CHCHSi(CH).

The non-catalytic hydrosilylation reaction has much high activation energy due to large differences in the energy of HOMO-LUMO pairing and restriction of the orbital symmetry overlap. For Pt(0)-catalytic hydrosilylation, the electronic structure of MeSiH has been modified by the oxidative addition of Pt(0). It not only narrows down the energy differences between the bonding orbitals but also improves the orbital overlap symmetry, leading to the effective decrease of the activation energy.

Ultrafine PtCoRh nanorods for highly efficient hydrogen evolution reaction in acid.

PtCoRh nanorods with an average width of 1.6 ± 0.2 nm show an overpotential of 6.

Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts.

Insufficient tumor accumulation and distribution of photosensitizers as well as low antitumor immunity severely restrict the therapeutic efficacy of photothermal therapy (PTT). Cancer-associated fibroblasts (CAFs) play a key role in tumor extracellular matrix (ECM) remodeling and immune evasion. Reshaping tumor microenvironment via CAF regulation might provide a potential approach for complete tumor elimination in combination with PTT.

Biodegradable electrospun nanofibrous platform integrating antiplatelet therapy-chemotherapy for preventing postoperative tumor recurrence and metastasis.

The perioperative trauma-related platelet recruitment and activation severely affect tumor recurrence and metastasis. Therefore, efficiently killing residual tumor cells and simultaneously inhibiting platelet activation to block platelet-cancer cell interaction might be a promising strategy to prevent postoperative tumor recurrence and metastasis. Biodegradable PLGA electrospun nanofibrous films co-delivering doxorubicin-loaded tumor repopulating cell-derived microparticles (DOX-MPs) and aspirin (ASA) were developed as the implant materials (DOX-MPs/ASA@NF) for postoperative in-situ treatment.

Levels and health risk assessment of pesticides and metals in Lycium barbarum L. from different sources in Ningxia, China.

The berries of Lycium barbarum L. (Goji) are widely used as a Chinese traditional herbal medicine and functional food because of their reported beneficial pharmacological effects. However, there are reports of Goji berries being contaminated by chemical residues that could pose a hazard to humans.