Early Intervention in Herpes Simplex Virus-1 Replication in Vitro with Allenic Macrolide Archangiumide.

Archangiumide is a unique macrolide natural product that features an endocyclic allene functionality, rendering it a prototype of a new class of secondary metabolites of microbial origin. However, its biological and/or pharmaceutical roles remain obscure. In this study, we have unveiled an antiviral potency of archangiumide that was effective against herpes simplex virus (HSV-1) replication.

Recent Advance in the Synthesis and Applications of Chiral Covalent Organic Frameworks: A Mini-Review.

Chiral covalent organic frameworks (CCOFs) are emerging porous materials with tunable chiral structures, abundant pores, and high surface areas, gaining significant attentions in separation, sensing, and asymmetric catalysis. This review summarizes the synthesis methods of CCOFs and their applications in chiral recognition. It discusses the advantages and limitations of three synthesis strategies, including chiral post-modification, direct synthesis, and chiral-induced synthesis.

Simulation and experimental verification of the precision finishing method for optical free-form surface segmentation.

Optical free-form surfaces are often used to manufacture optical components such as lenses and mirrors, and free zone surface optical components are widely used in aerospace optics. To address the issues of low processing quality and overall efficiency in the machining of aluminum alloy free-form surfaces, an efficient numerical control machining method based on surface segmentation has been proposed. The segmentation of free-form surfaces is divided into two stages: the recognition of surface partitions and the determination of surface boundaries.

The intricate ballet of inflammation and autophagy: Insights from Mycoplasma gallisepticum-infected HD11 cells.

Objectives: Mycoplasma gallisepticum (M. gallisepticum) infection often leads to inflammatory damage and immunosuppression. Macrophages play a crucial role as the primary immune defense in chickens, with their inflammatory response and autophagy levels critical.

Iruplinalkib for G1202R-mutant non-small cell lung cancer with anaplastic lymphoma kinase double fusion failed to alectinib: a case report.

The novel and highly selective anaplastic lymphoma kinase (ALK) inhibitor iruplinalkib showed potent activity and manageable safety profiles in patients with ALK-rearranged non-small cell lung cancer (NSCLC). However, the evidence of iruplinalkib for uncommon ALK double fusion and secondary G1202R resistance mutation is limited. Here, we report a case of a 36-year-old male with metastatic NSCLC harboring uncommon TTC7A-ALK and EML4-ALK double fusion.

Two-Dimensional Magnetic Exciton Polariton with Strongly Coupled Atomic and Photonic Anisotropies.

Anisotropy is a fundamental property of both material and photonic systems. The interplay between material and photonic anisotropies, however, has hardly been explored due to the vastly different length scales. Here we demonstrate exciton polaritons in a 2D antiferromagnet, CrSBr, coupled with an anisotropic photonic crystal cavity, where the spin, atomic, and photonic anisotropies are strongly correlated.

Correction: Hu et al. Dynamics of Nanomotors Propelled by Enzyme Cascade Reactions. 2024, , 12586.

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Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023.

Background: The glomerular podocyte endoplasmic reticulum is a critical component in renal function, yet its research landscape is not fully understood. This study aims to map the existing research on podocyte endoplasmic reticulum by analyzing publications in the Web of Science Core Collection (WOSCC) from the past 19 years.

Methods: We conducted a bibliometric analysis using Citespace, VOSviewer, the Metrology Literature Online platform, and the Bibliometrix software package to visualize and interpret the data from WOSCC.

Lifetime risk and projected burden of dementia.

Understanding the lifetime risk of dementia can inform public health planning and improve patient engagement in prevention. Using data from a community-based, prospective cohort study (n = 15,043; 26.9% Black race, 55.

Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury.

Background: Neuropathic pain resulting from spinal cord injury (SCI) is associated with persistent hyperactivity of primary nociceptors. Anandamide (AEA) has been reported to modulate neuronal excitability and synaptic transmission through activation of cannabinoid type-1 receptors (CB1Rs) and transient receptor potential vanilloid 1 (TRPV1). However, the role of AEA and these receptors in the hyperactivity of nociceptors after SCI remains unclear.

Clinical characteristics of IgG4-related retroperitoneal fibrosis in a cohort of 117 patients with idiopathic retroperitoneal fibrosis: a retrospective study.

Objective: Retroperitoneal fibrosis (RPF) is a rare condition marked by inflammation and fibrosis affecting the peritoneal and retroperitoneal soft tissues. In recent years, the identification of IgG4-related diseases has brought to light a significant association with fibrous disorders, including RPF, which were once considered independent. In this comprehensive cohort study, we performed a comparative analysis of the demographic, clinical, laboratory, histopathological, and therapeutic characteristics between patients with IgG4-related RPF and those with idiopathic retroperitoneal fibrosis (iRPF).

Challenge-Hindrance Stressors and Novice Nurses' Safety Behaviour: The Mediating Role of Regulatory Focus and the Moderating Role of Workplace Spirituality.

Aims: This study aims to investigate the impact of challenge-hindrance stressors on novice nurses' safety behaviour, the mediating effect of regulatory focus, and the moderating effect of workplace spirituality.

Background: The relationship between challenge-hindrance stressors and novice nurses' safety behaviour has rarely been investigated, despite the global concern for patient safety in healthcare systems. Previous research suggests that regulatory focus and workplace spirituality matter for nurse safety behaviour, but the relationship between them remains unclear.

Study on the effect of occupational exposure on hypertension of steelworkers based on Lasso-Logistic regression model.

Objectives: This study aimed to use a stable and predictive method: Lasso regression model to analyze hypertension's influencing factors and explore the interactions between occupational exposures.

Study Design: This has been a nested case-control study.

Methods: The case group consisted of 959 patients with high blood pressure found during the study.

Raman Spectral Feature Enhancement Framework for Complex Multiclassification Tasks.

Raman spectroscopy enables label-free clinical diagnosis in a single step. However, identifying an individual carrying a specific disease from people with a multi-disease background is challenging. To address this, we developed a Raman spectral implicit feature augmentation with a Raman Intersection, Union, and Subtraction augmentation strategy (RIUS).

Dynamics of Nanomotors Propelled by Enzyme Cascade Reactions.

Enzyme-powered nanomotors have attracted significant attention in materials science and biomedicine for their biocompatibility, versatility, and the use of biofuels in biological environments. Here, we employ a hybrid mesoscale method combining molecular dynamics and multi-particle collision dynamics (MD-MPC) to study the dynamics of nanomotors powered by enzyme reactions. Two cascade enzymes are constructed to be layered on the same surface of a Janus colloid, providing a confined space that greatly enhances reaction efficiency.

Outcomes and risk factors for cardiac surgery during pregnancy: a 13-year, two-centre, retrospective cohort study.

Background: Cardiac surgery during pregnancy is complex and has significant risks for mothers and infants. The clinical outcomes and risk factors for complications are largely unknown. This study aimed to analyse the outcomes of cardiac surgeries during pregnancy and to investigate the risk factors for maternal postoperative outcomes from the two largest referral centres for pregnant patients with complex cardiac disease in northern and southern China.

Theoretical study of a highly fault-tolerant and scalable adaptive radiative cooler.

Conventional static radiative coolers have an unadjustable cooling capacity, which often results in overcooling in low temperature environment. Therefore, there is a great need for an adaptive dynamic radiative cooler. However, such adaptive coolers usually require complex preparation processes.

Construction of carbazole-conjugated dual-emission fluorescent covalent organic framework for distinguishing p-nitroaniline/p-nitrophenol and adsorbing nitroanilines/nitrophenols.

Nitroanilines (NAs) and nitrophenols (NPs), crucial industrial raw materials, are extensively utilized across various sectors. However, the environmental pollution and health hazards stemming from their usage are significant, necessitating urgent monitoring and removal to address environmental and safety concerns. The challenge is further compounded by the presence of NAs/NPs isomers, making the selective analysis of specific isomers crucial.

Combinatorial treatment with traditional medicinal preparations and VEGFR-tyrosine kinase inhibitors for middle-advanced primary liver cancer: A systematic review and meta-analysis.

Background: This study aimed to investigate the therapeutic efficacy and safety of Traditional medicine preparations (TMPs) given in combination with vascular endothelial growth factor receptor (VEGFR)-associated multi-targeted tyrosine kinase inhibitors (TKIs) for the treatment of middle to advanced-stage primary liver cancer (PLC).

Methods: This systematic literature survey employed 10 electronic databases and 2 clinical trial registration platforms to identify relevant studies on the use of TMPs + VEGFR-TKIs to treat patients with middle-advanced PLC. Furthermore, a meta-analysis was performed following the PRISMA guidelines using the risk ratio (RR) at 95% confidence intervals (CI) or standardized mean difference as effect measures.

Corrigendum: Clinical efficacy of unilateral laminotomy for bilateral decompression in the treatment of adjacent segment disease after lumbar fusion.

[This corrects the article DOI: 10.3389/fsurg.2024.

Prediabetes is associated with elevated risk of clinical outcomes even without progression to diabetes.

Aims/hypothesis: Prediabetes (HbA 39-47 mmol/mol [5.7-6.4%] or fasting glucose 5.

Smart Implantable Hydrogel for Large Segmental Bone Regeneration.

Large segmental bone defects often lead to nonunion and dysfunction, posing a significant challenge for clinicians. Inspired by the intrinsic bone defect repair logic of "vascularization and then osteogenesis", this study originally reports a smart implantable hydrogel (PDS-DC) with high mechanical properties, controllable scaffold degradation, and timing drug release that can proactively match different bone healing cycles to efficiently promote bone regeneration. The main scaffold of PDS-DC consists of polyacrylamide, polydopamine, and silk fibroin, which endows it with superior interfacial adhesion, structural toughness, and mechanical stiffness.

The Development and Application of KinomePro-DL: A Deep Learning Based Online Small Molecule Kinome Selectivity Profiling Prediction Platform.

Characterizing the kinome selectivity profiles of kinase inhibitors is essential in the early stages of novel small-molecule drug discovery. This characterization is critical for interpreting potential adverse events caused by off-target polypharmacology effects and provides unique pharmacological insights for drug repurposing development of existing kinase inhibitor drugs. However, experimental profiling of whole kinome selectivity is still time-consuming and resource-demanding.