Volatile organic compounds emission characteristics and factors from stage-dependent combustion in typical biomass stoves in northern China: Field measurements and environmental implications.

Residential biomass burning (RBB) has significant impact on the ambient air quality in rural China. To explore the detailed emission characteristics and impact of various stove types and their combustion stages of RBB, which unresolved issue in existing studies, this study investigated the volatile organic compounds (VOCs) emissions of different combustion stages from four typical RBB stoves in Northern China, including kang stove (KS), brick stove (BS), metal stove (MS) and pellet stove (PS). The KS has the highest VOCs emission factors (EFs) (1.

A general deep learning model for predicting and classifying pea protein content via visible and near-infrared spectroscopy.

Rapid and accurate detection of pea protein content is crucial for breeding and ensuring food quality. This study introduces the PeaNet model, which employs an improved convolutional neural network architecture to predict and classify pea protein content. The model was developed using 156 visible and near-infrared spectral datasets from 52 varieties cultivated under varied conditions.

The landscape of decidual immune cells at the maternal-fetal interface in parturition and preterm birth.

Background: Parturition is similar to an inflammatory response in which resident and infiltrating immune cells release cytokines and chemokines into the maternal-fetal interface, promoting expulsion of the fetus from the mother. The untimely activation of these inflammatory pathways can result in preterm labor. The maternal-fetal interface is composed mainly of decidual tissue and placental villous space.

Insight into carbonyl source based on improved source apportionment method: Alkene regulate secondary formation.

Carbonyls can be emitted by human activities or produced by photochemical oxidation. However, there is a lack of accurate methods for separately analyzing the primary and secondary sources of carbonyls, which is important for industrial cities with large carbonyls emission. Combined the method of multiple linear regression, positive matrix factorisation (PMF) and observation-based model (OBM), this study improved the source apportionment method of carbonyl and conducted research in a typical industrial city in North China during different seasons.

A highly sensitive and colorimetric fluorescent sensor for visualizing Zn in aqueous solution.

A new colorimetric fluorescent sensor QPEBT was developed by merging the N,N-di(2-picolyl)ethane-1,2-diamine and 2,2'-bithiophene moieties into the quinolimide backbone. QPEBT could sensitively detect Zn through the remarkable fluorescence enhancement with distinct color changes from light orange to pink in visible light and from ginger to orange-yellow in 365 nm UV irradiation. The 1:1 stoichiometry between QPEBT and Zn was verified by the spectra titrations, Job's and HRMS analyses, and theoretical calculations.

[Casticin inhibits proliferation of non-small cell lung cancer cells by regulating glucose metabolism through suppression of HIF-1α].

The study investigated the effect of casticin on the proliferation of non-small cell lung cancer(NSCLC) H322 cells and explored its molecular mechanism. Firstly, the cell counting kit-8(CCK-8) assay, colony formation assay, and EdU assay were used to detect the effect of casticin on the proliferation capacity of H322 cells under different concentrations and treatment durations. Then, glucose uptake, lactate production, extracellular pH, and oxygen consumption of H322 cells were measured before and after casticin treatment to analyze its impact on glycolysis in NSCLC H322 cells.

Modeling the interplay between regional heterogeneity and critical dynamics underlying brain functional networks.

The human brain exhibits heterogeneity across regions and network connectivity patterns; However, how these heterogeneities contribute to whole-brain network functions and cognitive capacities remains unclear. In this study, we focus on the regional heterogeneity reflected in local dynamics and study how it contributes to the emergence of functional connectivity patterns, network ignition dynamics of the empirical brains. We find that the level of synchrony among voxelwise neural activities measured from the fMRI data is significantly correlated with the transcriptional variations in excitatory and inhibitory receptor gene expression.

Adverse reactions associated with SSRIs and PD-1/PD-L1 inhibitors: a disproportionality analysis of the FDA Adverse Event Reporting System.

Background: Selective serotonin reuptake inhibitors (SSRIs) are the primary choice for antidepressant therapy in cancer patients with depression. Programmed death-1 and programmed cell death-ligand 1 (PD-1/PD-L1) play a critical role in immune checkpoint inhibitors. To date, there have been no studies reporting adverse events (AEs) associated with the real-world use of PD-1/PD-L1 inhibitors-SSRIs combination.

Casticin inhibits proliferation of Non-small cell lung cancer cells through regulating reprogramming of glucose metabolism.

Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with poor prognosis due to its rapid progression and resistance to existing therapies. Metabolic reprogramming, particularly alterations in glucose metabolism, is a key mechanism underlying tumor growth and progression, providing potential targets for novel therapeutic strategies. Casticin (CAS), a bioactive flavonoid, has shown anticancer effects in various cancers, but its specific role in NSCLC metabolism remains unclear.

Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases.

Alternative splicing contributes to complex traits, but whether this differs in trait-relevant cell types across diverse genetic ancestries is unclear. Here we describe cell-type-specific, sex-biased and ancestry-biased alternative splicing in ~1 M peripheral blood mononuclear cells from 474 healthy donors from the Asian Immune Diversity Atlas. We identify widespread sex-biased and ancestry-biased differential splicing, most of which is cell-type-specific.

Vegetation Restoration Increases the Drought Risk on the Loess Plateau.

The extensive implementation of the 'Grain for Green' project over the Loess Plateau has improved environmental quality. However, it has resulted in a greater consumption of soil water, and its overall hydrological effects remain highly controversial. Our study utilized a coupled land-atmosphere model to evaluate the effects of vegetation changes resulting from revegetation or reclamation on the hydrology of the Loess Plateau.

Near-Infrared-Emitting Helically Twisted Conjugated Frameworks Consisting of Alternant Donor-π-Acceptor Units and Multiple Boron Atoms.

A novel design strategy to construct bright and narrow near-infrared (NIR) emission materials with suppressed shoulder peaks can significantly enhance their performance in various applications. Herein, we have successfully synthesized a series of helically twisted D-π-A conjugated systems bridged by boron atoms, achieving bright red to near-infrared (NIR) emissions with notably narrow full-width at half-maximum (FWHM) values of 35 nm (0.08 eV) and photoluminescence quantum yields (PLQY) up to 80 %.

Continuum percolation of two-dimensional adaptive dynamics systems.

The percolation phase transition of a continuum adaptive neuron system with homeostasis is investigated. In order to maintain their average activity at a particular level, each neuron (represented by a disk) varies its connection radius until the sum of overlapping areas with neighboring neurons (representing the overall connection strength in the network) has reached a fixed target area for each neuron. Tuning the two key parameters in the model, i.

Fluoranthene degradation in a persulfate system activated by sulfidated nano zero-valent iron (S-nZVI): performance and mechanisms.

Fluoranthene (FLT) has received mounting focus due to its hazardous properties and frequent occurrence in groundwater. In this study, sulfidated nano zero-valent iron (S-nZVI) was selected as an efficient catalyst for activating persulfate (PS) to degrade FLT. The effects of reagent doses, various water conditions (pH, anions, and humic acid), and the presence of surfactants on FLT degradation were investigated.

Evidence for sustainably reducing secondary pollutants in a typical industrial city in China: Co-benefit from controlling sources with high reduction potential beyond industrial process.

Under China's strict industrial control measures, the reduction of secondary pollutants (O and secondary organic aerosols [SOA]) and precursors (volatile organic compounds [VOCs] and NOx) caused by industrial processes has encountered bottlenecks. In this study, the net O formation rate (Net [O]) in summer and the self-reaction rate between peroxy radicals (Self-Rnxs) in winter are used to characterize the formation potentials of O and SOA, respectively. Assuming that the precursor reduction ratio based on emission inventories is approximately equal to that based on observed concentrations, this study combines emission inventory and observation-based model (OBM) methods to indicate the potential source of secondary pollutants reduction.

Maleic Anhydride and (Ethoxy)pentafluorocyclotriphosphazene as Electrolyte Additives for High-Voltage LiCoO/Si-Graphite Lithium-Ion Batteries.

Anhydride additives including maleic anhydride and succinic anhydride are initially selected as additives in the commercial electrolytes for high-voltage lithium-ion batteries with a Si-based anode. The introduction of (ethoxy)pentafluorocyclotriphosphazene as a flame retardant realizes the nonflammability of electrolytes, and the conductivity of electrolytes exceeds 10 mS cm at 25 °C. Maleic anhydride and (ethoxy)pentafluorocyclotriphosphazene jointly contribute to the exceptional performances of 4.

Pulsatilla decoction alleviates DSS-induced UC by activating FXR-ASBT pathways to ameliorate disordered bile acids homeostasis.

Pulsatilla decoction (PD) is a classical prescription for the treatment of ulcerative colitis. Previous studies have demonstrated that the therapeutic efficacy of PD is closely associated with the activation of Farnesoid X receptor (FXR). The activity of FXR is regulated by apical sodium-dependent bile acid transporter (ASBT), and the FXR-ASBT cascade reaction, centered around bile acid receptor FXR, plays a pivotal role in maintaining bile acid metabolic homeostasis to prevent the occurrence and progression of ulcerative colitis (UC).

Research on the mechanism of Guanyu Zhixie Granule in intervening gastric ulcers in rats based on network pharmacology and multi-omics.

Objective: Guanyu Zhixie Granule (GYZXG) is a traditional Chinese medicine compound with definite efficacy in intervening in gastric ulcers (GUs). However, the effect mechanisms on GU are still unclear. This study aimed to explore its mechanism against GU based on amalgamated strategies.

Combining Mefloquine with an Mcl-1 Inhibitor as a Novel Therapeutic Strategy for the Treatment of Nasopharyngeal Carcinoma.

Considering the established pharmacokinetics and toxicity profiles, drug repurposing has emerged as an alternative therapeutic approach for treating cancer. Mefloquine has previously demonstrated inhibitory effects on multiple cancer types. This study aims to explore the impact of mefloquine on nasopharyngeal carcinoma (NPC).

Analyzing ozone formation sensitivity in a typical industrial city in China: Implications for effective source control in the chemical transition regime.

Volatile organic compounds (VOCs) play a major role in O formation in urban environments. However, the complexity in the emissions of VOCs and nitrogen oxides (NOx) in industrial cities has made it challenging to identify the key factors influencing O formation. This study used observation-based-model (OBM) to analyze O sensitivities to VOCs and NOx during summer in a typical industrial city in China.