Residential biomass burning (RBB) has significant impact on the ambient air quality in rural China. To explore the detailed emission characteristics and impact of various stove types and their combustion stages of RBB, which unresolved issue in existing studies, this study investigated the volatile organic compounds (VOCs) emissions of different combustion stages from four typical RBB stoves in Northern China, including kang stove (KS), brick stove (BS), metal stove (MS) and pellet stove (PS). The KS has the highest VOCs emission factors (EFs) (1.
View Article and Find Full Text PDFRapid and accurate detection of pea protein content is crucial for breeding and ensuring food quality. This study introduces the PeaNet model, which employs an improved convolutional neural network architecture to predict and classify pea protein content. The model was developed using 156 visible and near-infrared spectral datasets from 52 varieties cultivated under varied conditions.
View Article and Find Full Text PDFBackground: Parturition is similar to an inflammatory response in which resident and infiltrating immune cells release cytokines and chemokines into the maternal-fetal interface, promoting expulsion of the fetus from the mother. The untimely activation of these inflammatory pathways can result in preterm labor. The maternal-fetal interface is composed mainly of decidual tissue and placental villous space.
View Article and Find Full Text PDFCarbonyls can be emitted by human activities or produced by photochemical oxidation. However, there is a lack of accurate methods for separately analyzing the primary and secondary sources of carbonyls, which is important for industrial cities with large carbonyls emission. Combined the method of multiple linear regression, positive matrix factorisation (PMF) and observation-based model (OBM), this study improved the source apportionment method of carbonyl and conducted research in a typical industrial city in North China during different seasons.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
April 2025
A new colorimetric fluorescent sensor QPEBT was developed by merging the N,N-di(2-picolyl)ethane-1,2-diamine and 2,2'-bithiophene moieties into the quinolimide backbone. QPEBT could sensitively detect Zn through the remarkable fluorescence enhancement with distinct color changes from light orange to pink in visible light and from ginger to orange-yellow in 365 nm UV irradiation. The 1:1 stoichiometry between QPEBT and Zn was verified by the spectra titrations, Job's and HRMS analyses, and theoretical calculations.
View Article and Find Full Text PDFThe study investigated the effect of casticin on the proliferation of non-small cell lung cancer(NSCLC) H322 cells and explored its molecular mechanism. Firstly, the cell counting kit-8(CCK-8) assay, colony formation assay, and EdU assay were used to detect the effect of casticin on the proliferation capacity of H322 cells under different concentrations and treatment durations. Then, glucose uptake, lactate production, extracellular pH, and oxygen consumption of H322 cells were measured before and after casticin treatment to analyze its impact on glycolysis in NSCLC H322 cells.
View Article and Find Full Text PDFThe human brain exhibits heterogeneity across regions and network connectivity patterns; However, how these heterogeneities contribute to whole-brain network functions and cognitive capacities remains unclear. In this study, we focus on the regional heterogeneity reflected in local dynamics and study how it contributes to the emergence of functional connectivity patterns, network ignition dynamics of the empirical brains. We find that the level of synchrony among voxelwise neural activities measured from the fMRI data is significantly correlated with the transcriptional variations in excitatory and inhibitory receptor gene expression.
View Article and Find Full Text PDFBackground: Selective serotonin reuptake inhibitors (SSRIs) are the primary choice for antidepressant therapy in cancer patients with depression. Programmed death-1 and programmed cell death-ligand 1 (PD-1/PD-L1) play a critical role in immune checkpoint inhibitors. To date, there have been no studies reporting adverse events (AEs) associated with the real-world use of PD-1/PD-L1 inhibitors-SSRIs combination.
View Article and Find Full Text PDFBackground: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with poor prognosis due to its rapid progression and resistance to existing therapies. Metabolic reprogramming, particularly alterations in glucose metabolism, is a key mechanism underlying tumor growth and progression, providing potential targets for novel therapeutic strategies. Casticin (CAS), a bioactive flavonoid, has shown anticancer effects in various cancers, but its specific role in NSCLC metabolism remains unclear.
View Article and Find Full Text PDFAlternative splicing contributes to complex traits, but whether this differs in trait-relevant cell types across diverse genetic ancestries is unclear. Here we describe cell-type-specific, sex-biased and ancestry-biased alternative splicing in ~1 M peripheral blood mononuclear cells from 474 healthy donors from the Asian Immune Diversity Atlas. We identify widespread sex-biased and ancestry-biased differential splicing, most of which is cell-type-specific.
View Article and Find Full Text PDFPlants (Basel)
September 2024
The extensive implementation of the 'Grain for Green' project over the Loess Plateau has improved environmental quality. However, it has resulted in a greater consumption of soil water, and its overall hydrological effects remain highly controversial. Our study utilized a coupled land-atmosphere model to evaluate the effects of vegetation changes resulting from revegetation or reclamation on the hydrology of the Loess Plateau.
View Article and Find Full Text PDFA novel design strategy to construct bright and narrow near-infrared (NIR) emission materials with suppressed shoulder peaks can significantly enhance their performance in various applications. Herein, we have successfully synthesized a series of helically twisted D-π-A conjugated systems bridged by boron atoms, achieving bright red to near-infrared (NIR) emissions with notably narrow full-width at half-maximum (FWHM) values of 35 nm (0.08 eV) and photoluminescence quantum yields (PLQY) up to 80 %.
View Article and Find Full Text PDFThe percolation phase transition of a continuum adaptive neuron system with homeostasis is investigated. In order to maintain their average activity at a particular level, each neuron (represented by a disk) varies its connection radius until the sum of overlapping areas with neighboring neurons (representing the overall connection strength in the network) has reached a fixed target area for each neuron. Tuning the two key parameters in the model, i.
View Article and Find Full Text PDFFluoranthene (FLT) has received mounting focus due to its hazardous properties and frequent occurrence in groundwater. In this study, sulfidated nano zero-valent iron (S-nZVI) was selected as an efficient catalyst for activating persulfate (PS) to degrade FLT. The effects of reagent doses, various water conditions (pH, anions, and humic acid), and the presence of surfactants on FLT degradation were investigated.
View Article and Find Full Text PDFUnder China's strict industrial control measures, the reduction of secondary pollutants (O and secondary organic aerosols [SOA]) and precursors (volatile organic compounds [VOCs] and NOx) caused by industrial processes has encountered bottlenecks. In this study, the net O formation rate (Net [O]) in summer and the self-reaction rate between peroxy radicals (Self-Rnxs) in winter are used to characterize the formation potentials of O and SOA, respectively. Assuming that the precursor reduction ratio based on emission inventories is approximately equal to that based on observed concentrations, this study combines emission inventory and observation-based model (OBM) methods to indicate the potential source of secondary pollutants reduction.
View Article and Find Full Text PDFAnhydride additives including maleic anhydride and succinic anhydride are initially selected as additives in the commercial electrolytes for high-voltage lithium-ion batteries with a Si-based anode. The introduction of (ethoxy)pentafluorocyclotriphosphazene as a flame retardant realizes the nonflammability of electrolytes, and the conductivity of electrolytes exceeds 10 mS cm at 25 °C. Maleic anhydride and (ethoxy)pentafluorocyclotriphosphazene jointly contribute to the exceptional performances of 4.
View Article and Find Full Text PDFPulsatilla decoction (PD) is a classical prescription for the treatment of ulcerative colitis. Previous studies have demonstrated that the therapeutic efficacy of PD is closely associated with the activation of Farnesoid X receptor (FXR). The activity of FXR is regulated by apical sodium-dependent bile acid transporter (ASBT), and the FXR-ASBT cascade reaction, centered around bile acid receptor FXR, plays a pivotal role in maintaining bile acid metabolic homeostasis to prevent the occurrence and progression of ulcerative colitis (UC).
View Article and Find Full Text PDFObjective: Guanyu Zhixie Granule (GYZXG) is a traditional Chinese medicine compound with definite efficacy in intervening in gastric ulcers (GUs). However, the effect mechanisms on GU are still unclear. This study aimed to explore its mechanism against GU based on amalgamated strategies.
View Article and Find Full Text PDFConsidering the established pharmacokinetics and toxicity profiles, drug repurposing has emerged as an alternative therapeutic approach for treating cancer. Mefloquine has previously demonstrated inhibitory effects on multiple cancer types. This study aims to explore the impact of mefloquine on nasopharyngeal carcinoma (NPC).
View Article and Find Full Text PDFVolatile organic compounds (VOCs) play a major role in O formation in urban environments. However, the complexity in the emissions of VOCs and nitrogen oxides (NOx) in industrial cities has made it challenging to identify the key factors influencing O formation. This study used observation-based-model (OBM) to analyze O sensitivities to VOCs and NOx during summer in a typical industrial city in China.
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