A dual mode biosensor based on self-enhanced polyfluorene nanomaterial for fluorescence and electrochemiluminescence detection of Tau protein.

Dual mode detection can overcome the poor anti-interference ability of single-mode detection, and greatly improve the detection accuracy. Fluorescence/electrochemiluminescence (FL/ECL) dual mode detection combines the advantages of FL and ECL, and has a promising application in bioanalysis. Common FL/ECL dual mode detection used different signal probes.

Digital Economy and carbon emission efficiency in three major urban agglomerations of China: A U-shaped journey towards green development.

Amidst the global consensus on green transformation and sustainable development, the digital economy has emerged as a pivotal catalyst for enhancing carbon emission efficiency. Analyzing panel data of 49 cities in Beijing-Tianjin-Hebei (BTH), Yangtze River Delta (YRD), and Pearl River Delta (PRD) from 2011 to 2022, this study explores the U-shaped journey of the digital economy towards green development. The rebound effect on energy consumption from early digital infrastructure investments delays the long-term benefits of digital applications in boosting carbon performance, and the thresholds of DE in BTH, YRD, and PRD regions are 0.

Association of mutation profiles with metastasis in patients with non-small cell lung cancer.

Objective: This study focused on the analysis of the correlation between common gene mutation types and metastatic sites in NSCLC patients.

Methods: We retrospectively studied 1586 NSCLC patients and used fluorescence Polymerase chain reaction (PCR) to detect EGFR, ALK, ROS1, RET, MET, BRAF, HER2, KRAS, NRAS, and PIK3CA gene mutations, and also investigated sex, smoking status, age at diagnosis, histological type and TNM stage. In addition, we analyzed the site of metastasis in patients with stage IV NSCLC.

Non-Fused Star-Shape Giant Trimer Electron Acceptors for Organic Solar Cells with Efficiency over 19 .

Organic solar cells (OSCs) based on giant molecular acceptors (GMAs) have attracted extensive attention due to their excellent power conversion efficiency (PCE) and operation stability. However, the large conjugated plane of GMAs poses great challenges in regulating the solubility, over-size aggregation and yield, which in turn further constrains their development in commercial products. Herein, we employ a non-fused skeleton strategy to develop novel non-fused star-shape trimers (3BTT6F and 3BTT6Cl) for improving device performance.

Dynamic simulation of policy-driven green technology innovation networks: Digital empowerment and collaborative efficiency.

To delve into the intricate dynamics of green innovation, it is imperative to establish a policy-driven green innovation network and optimize its multi-entity collaborative mechanism. Given the dynamic complexity of a technological innovation network composed of multiple entities, this paper examines the interactions among four subsystems based on system dynamics (SD) simulation: resource input, innovation performance, policy-driven, and digital empowerment subsystem. Furthermore, we analyze the combined effects of policy-driven initiatives and the role of digital platforms in facilitating innovation efficiency based on empirical evidence.

Benefits of osimertinib treat a lung adenocarcinoma patient with germline EGFR T790M, somatic EGFR 19-Del, TP53 and PIK3CA mutations.

Background: Somatic mutations in the EGFR gene occur in about 50% of non-small cell lung cancers, with the T790M mutation significantly contributing to secondary resistance against EGFR-TKI drugs. However, EGFR T790M germline mutations rarely occur.

Case Presentation: In this study, we report a case of a lung adenocarcinoma family lineage linked to a germline EGFR T790M mutation.

Acceptor-only oligomers with high coplanarity enable efficient and stable organic solar cells.

Acceptor-only oligomers are developed as guest components to construct oligomer-assisted active layers for high performance organic solar cells. Due to the high planarity and structural similarity with the host polymer donor, BDD-based acceptor-only oligomers formed an alloy phase with PM6 and optimized the phase morphology effectively, achieving a stable device displaying 18% efficiency.

Coreactant-free electrochemiluminescence of polyfluorene nanoparticle coupling double quencher for β-amyloid detection.

β-amyloid (Aβ) is a humoral biomarker for early diagnosis of Alzheimer's disease (AD), and exists at a low level in human body. Its sensitive detection is very valuable. The electrochemiluminescence (ECL) assay of Aβ has attracted special attention owing to high sensitivity and simple operation.

The role of data-driven services strategy in platform competition: A system performance perspective.

In the era of big data, data-driven services (DDS) have become critical competitive strategies for digital platform-based enterprises. This paper considers two operational modes of e-commerce platforms, which are self-operated and third-party modes, respectively, and they each lead a platform system. The Hotelling model is adopted to describe the competitive market of both platforms.

Optimization and selection of cause marketing mode with the warm glow effect.

Cause marketing (CM) is an important way of implementing corporate social responsibility (CSR) strategies. While most related studies explore firms' implementation of CM campaigns, which involve donation of part of their sales revenue to charity for a social cause, we focus on the case of a firm contributing a specific ratio of its sales quantity to implement the CM campaign and divide the CM campaign mix into four modes according to different CM implementation subjects and the wholesale price (exogenous or endogenous). Unlike firms in the supply chain that use donation amounts to implement CM, the implementation of CM by donation ratio will be influenced by the donation cost, which can further affect their pricing strategies.

Contract choice and advance selling strategy in a supply chain of FAP.

The advance selling (AS) has been widely applied in fresh industry for it can elevating the customer experience and increase flexibility thus profit for a retailer. However, the introduction of the AS will have an impact on spot market in pricing strategy, market share and the profit of the retailer. Hence, to coordinate the supply chain and improve the efficiency of the agricultural supply chain, a two-stage game theory model is constructed to analyze the effects of AS on three classic contracts: wholesale price, quantity discount and revenue-sharing contract.

Efficacy and safety of SOX chemotherapy with or without surgery in AFP-producing advanced gastric cancer.

The present study investigated the clinical efficacy of S-1 plus oxaliplatin (SOX) regimen, with or without surgery in α-fetoprotein-producing gastric cancer (APGC) with liver metastasis. A total of 24 patients with APGC treated at the Liaocheng People's Hospital between January 2011 and December 2013 were retrospectively reviewed. Clinical efficacy and patient safety were compared between the two groups.

Cytokine-induced killer cells/dendritic cells and cytokine-induced killer cells immunotherapy for the treatment of esophageal cancer in China: a meta-analysis.

Background: Immunotherapy based on cytokine-induced killer cells or combination of dendritic cells and cytokine-induced killer cells (CIK/DC-CIK) showed promising clinical outcomes for treating esophageal cancer (EC). However, the clinical benefit varies among previous studies. Therefore, it is necessary to systematically evaluate the curative efficacy and safety of CIK/DC-CIK immunotherapy as an adjuvant therapy for conventional therapeutic strategies in the treatment of EC.

Cytokine-induced killer cells/dendritic cells-cytokine induced killer cells immunotherapy combined with chemotherapy for treatment of colorectal cancer in China: a meta-analysis of 29 trials involving 2,610 patients.

Purpose: To systematically evaluate the efficacy and safety of Cytokine-induced killer cells/dendritic cells-cytokine induced killer cells (CIK/DC-CIK) immunotherapy in treating advanced colorectal cancer (CRC) patients.

Results: 29 trials including 2,610 CRC patients were evolved. Compared with chemotherapy alone, the combination of chemotherapy with CIK/DC-CIK immunotherapy significantly prolonged the overall survival rate (OS) and disease-free survival rate (DFS) (1-5 year OS, P < 0.

Efficacy and safety of cord blood-derived dendritic cells plus cytokine-induced killer cells combined with chemotherapy in the treatment of patients with advanced gastric cancer: a randomized Phase II study.

Background: Cellular immunotherapy has been widely used in the treatment of solid tumors. However, the clinical application of cord blood-derived dendritic cells and cytokine-induced killer cells (CB-DC-CIK) for the treatment of gastric cancer has not been frequently reported. In this study, the efficacy and safety of CB-DC-CIK for the treatment of gastric cancer were evaluated both in vitro and in vivo.

MiR-454 prompts cell proliferation of human colorectal cancer cells by repressing CYLD expression.

Previous studies have shown that miR-454 plays an important role in a variety of biological processes in various human cancer cells. However, the underlying mechanisms of this microRNA in colorectal cancer (CRC) cells remain largely unknown. In the present study, we investigated the miR-454 role in CRC cell proliferation.

Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence.

Aim: To compare matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 in gastric ulcer (GU) and chronic superficial gastritis (CSG).

Methods: This study enrolled 63 patients with GU and 25 patients with CSG. During upper gastroduodenal endoscopy, we took samples of gastric mucosa from the antrum and ulcer site from patients with GU, and samples of antral mucosa from patients with CSG.

Feasibility and safety of endoscopic submucosal dissection of esophageal or gastric carcinomas under general anesthesia.

Objective: To investigate the feasibility and safety of endoscopic submucosal dissection (ESD) of esophageal or gastric carcinomas under general anesthesia.

Subjects And Methods: ESD removal of esophageal or gastric carcinomas was performed in 59 patients under midazolam sedation (control group), and in 46 patients under general anesthesia (GA group). The procedural times, perioperative complications and patient's satisfaction with the procedures were recorded.