Potential Biomarker of Acute Anthracycline-induced Cardiotoxicity Among Children With Acute Lymphoblastic Leukemia: Cardiac Adriamycin-responsive Protein.

This study aimed to investigate whether serum cardiac adriamycin-responsive protein (CARP) can serve as a sensitive and specific biomarker of anthracyclines (ANT)-induced cardiotoxicity. Fifty-five children with acute lymphoblastic leukemia were recruited. Before and after the administration of ANT, serum levels of CARP, high-sensitivity troponin T, creatine kinase-MB, and electrocardiogram were measured.

An Image Study on Local Anesthetic Spread in Healthy Volunteers Receiving Subcostal Exterior Semilunaris Transversus Abdominis Plane (SE-TAP) Block.

Background: Despite the popularity of the ultrasound-guided transversus abdominis plane (TAP) block and the diversity of advancing approaches, the extent of injectate spread limits its clinical benefits. This study used three-dimensional computed tomography (3D-CT) imaging and a cold stimulus to evaluate the spread of a local anesthetic injected through the subcostal exterior semilunaris to transversus abdominis plane (SE-TAP) block in healthy volunteers.

Methods: Eight healthy volunteers received a right-side ultrasound-guided SE-TAP block with 25 mL of 0.

Fenofibrate reverses liver fibrosis in cholestatic mice induced by alpha-naphthylisothiocyanate.

Cholestatic liver fibrosis occurs in liver injuries accompanied by inflammation, which develops into cirrhosis if not effectively treated in early stage. The aim of the study is to explore the effect of fenofibrate on liver fibrosis in chronic cholestatic mice. In this study, wild-type (WT) and Pparα-null (KO) mice were dosed alpha-naphthylisothiocyanate (ANIT) diet to induce chronic cholestasis.

[The cholestatic fibrosis induced by α-naphthylisothiocyanate in mice and the inflammation pathway].

To explore the development of cholestatic fibrosis induced by α-naphthylisothiocyanate (ANIT) and the inflammation pathways. Fifteen 129/Sv mice weighing (23±2) g were randomly divided into 2 groups: control group (=5) and experiment group (=10). The control group was fed commercial chow diet and the experiment group was fed the same diet supplemented with 0.

Tunable bending stiffness of MoSe/WSe heterobilayers from flexural wrinkling.

Understanding the mechanical behaviors of van der Waals heterogeneous 2D materials is important for their actual applications. Our extensive first-principles calculations and continuum mechanical modeling on the wrinkling of MoSe/WSe heterobilayers caused by compression reveal that the bending stiffness of MoSe/WSe wrinkles strongly depend on the wrinkle structures, which first increase and then decrease with increasing the compressive strain. The bending stiffness of MoSe/WSe wrinkles could be effectively mediated and tuned by adjusting the wrinkle geometry and size.

Mechanical and electronic coupling in few-layer graphene and hBN wrinkles: a first-principles study.

Wrinkle engineering is an important pathway to develop novel functional devices of two-dimensional materials. By combining first-principles calculations and continuum mechanics modelling, we have investigated the wrinkling of few-layer graphene and hexagonal boron nitride (hBN) and provide a way to estimate their bending stiffness. For few-layer wrinkles under the same strain, the magnitude of structural deformation of each constituent layer gradually decreases from bottom to top layers, while interlayer interaction increases with increasing layer number.

Reduction of interfacial friction in commensurate graphene/h-BN heterostructures by surface functionalization.

The reduction of interfacial friction in commensurately stacked two-dimensional layered materials is important for their application in nanoelectromechanical systems. Our first-principles calculations on the sliding energy corrugation and friction at the interfaces of commensurate fluorinated-graphene/h-BN and oxidized-graphene/h-BN heterostructures show that the sliding energy barriers and shear strengths for these heterostructures are approximately decreased to 50% of those of commensurate graphene/h-BN. The adsorbed F and O atoms significantly suppress the interlayer electrostatic and van der Waals energy corrugations by modifying the geometry and charge redistribution of the graphene layers.