The role of miR-128 and MDFI in cardiac hypertrophy and heart failure: Mechanistic.

Heart failure (HF) prognosis depends on various regulatory factors; microRNA-128 (miR-128) is identified as a regulator of cardiac fibrosis, contributing to HF. MyoD family inhibitor (MDFI), which is reported to be related with Wnt/β-catenin pathway, is supposed to be regulated by miR-128. This study investigates the interaction between miR-128 and MDFI in cardiomyocyte development and elucidates its role in heart injury.

Risk factors for major adverse cardiovascular events after coronary artery bypass grafting using radial artery grafts.

Background: Coronary artery bypass grafting using radial artery grafts (RA-CABG) has improved long-term outcomes. However, major adverse cardiovascular events (MACE-4, including all-cause death, myocardial infarction, stroke, and repeat revascularization) after RA-CABG still occur and the predictors remain uncertain. This study aimed to detect independent risk factors of MACE-4 after RA-CABG.

genotype and platelet aggregation test-guided dual antiplatelet therapy after off-pump coronary artery bypass grafting: A retrospective cohort study.

Background: Dual antiplatelet therapy (DAPT) is recommended in patients undergoing off-pump coronary artery bypass graft surgery (OPCAB). Clopidogrel is less effective among patients with loss-of-function (LoF) of alleles, while ticagrelor has direct effects on P2Y receptor. Whether a genotype plus platelet aggregation test (PAgT)-guided DAPT after CABG could improve clinical outcomes remain uncertain.

Coronary Artery Magnetic Resonance Angiography Combined with Computed Tomography Angiography in Diagnosis of Coronary Heart Disease by Reconstruction Algorithm.

This research aimed at discussing the diagnosis effect of coronary artery magnetic resonance angiography (MRA) combined with computed tomography (CT) angiography (CTA) based on the back-projection filter reconstruction (BPFR) algorithm in coronary heart disease (CHD), and its role in the diagnosis of coronary artery disease (CAD). Sixty patients with CHD were selected and randomly rolled into group A (undergone MRA examination), group B (undergone CTA examination), and group C (undergone MRA + CTA), with 20 cases in each group. Taking the diagnostic results of coronary angiography as the gold standard, the MRA and CTA images were reconstructed using a BPFR algorithm, and a filter function was added to solve the problem of image sharpness.

Hybrid coronary revascularization versus total arterial revascularization for the treatment of left main coronary artery disease.

Background: Hybrid coronary revascularization (HCR) has a similar clinical outcome to coronary artery bypass grafting (CABG) in treating multivessel disease. However, the outcome of HCR in treating left main coronary artery (LM) disease is unclear. This study sought to compare the clinical outcome of HCR with total arterial revascularization (TAR) for treating LM disease.

Prognostic implications of left ventricular geometry in coronary artery bypass grafting patients.

Background: The prognostic implications of left ventricular (LV) mass and geometry have been confirmed in populations with different cardiac diseases. However, the prognostic value of LV geometry in coronary artery bypass grafting (CABG) patients is unclear.

Methods: A total of 2,517 patients undergoing CABG between January 2012 and September 2016 in our cardiac surgery unit were included.

Pericardial fluid levels of growth differentiation factor 15 in patients with or without coronary artery disease: a prospective study.

Background: Growth differentiation factor 15 (GDF15) has already been reported as a novel efficient biomarker in patients with coronary artery diseases (CAD). However, very little is demonstrated about the potential impact of pericardial fluid GDF-15 accumulation on CAD. The aim of this study was to evaluate pericardial fluid and plasma GDF15 levels in patients with ischemic heart disease.

Cox-2 Negatively Affects the Protective Role of Propofol against Hypoxia/Reoxygenation Induced Cardiomyocytes Apoptosis through Suppressing Akt Signaling.

Nowadays, the prevention of severe myocardium injury resulting from myocardial ischemia/reperfusion injury (I/R) has been recognized as an important subject in the field of ischemic heart disease. In this study, H9c2 cardiomyocytes were exposed to cycles of hypoxia/reoxygenation (H/R) to mimic myocardial I/R injury. Western blot analysis and qRT-PCR were performed to detect the expression of Cox-2, Akt and p-Akt.

Hybrid coronary revascularization versus off-pump coronary artery bypass grafting and percutaneous coronary intervention for the treatment of two-vessel coronary artery disease with proximal left anterior descending artery stenosis.

Background: This study sought to compare clinical outcomes of hybrid coronary revascularization (HCR) with off-pump coronary artery bypass grafting (OPCAB) and percutaneous coronary intervention (PCI) for the treatment of two-vessel coronary artery disease (CAD) including proximal LAD stenosis.

Methods: From January 2009 to December 2016, 52 patients of two-vessel CAD including proximal LAD stenosis underwent HCR at Rui Jin Hospital. Using propensity score methodology, these patients were matched with those in the OPCAB and PCI cohorts.

Predictors of early vein graft failure after off-pump coronary artery bypass grafting: angiocomputed tomographic results of 233 patients.

Objectives: Low saphenous vein graft (SVG) patency has become the bottleneck in surgical revascularization. This study aimed to identify the predictors of early vein graft failure (VGF) after off-pump coronary bypass grafting (OPCAB).

Methods: A total of 233 patients who had OPCAB were postoperatively evaluated by coronary computed tomography angiography.

Development of decellularized aortic valvular conduit coated by heparin-SDF-1α multilayer.

Background: Decellularization can reduce the immune response to aortic valve allograft tissue, but the thrombogenicity and in vivo remolding of these grafts remain controversial. The aim of the present study was to modify the surface of decellularized valvular conduits with heparin-stromal cell-derived factor-1α (SDF-1α) polyelectrolyte multilayer film and to test the thrombogenicity and biocompatibility in vitro and recellularization in vivo.

Methods: The donor aortic valvular conduits were decellularized with a combination of different detergents and were coated with heparin and SDF-1α alternately to form a polyelectrolyte multilayer.

Subacute biventricular rupture with extracardiac left-to-right shunt after an inferior acute myocardial infarction.

Cardiac rupture is an uncommon but catastrophic mechanical complication after acute myocardial infarction associated with an exceedingly high mortality. We report the case of a 64-year-old man who presented with a subacute biventricular rupture after acute inferior ST segment elevation myocardial infarction.