Phage therapy combats pan drug-resistant Acinetobacter baumannii infection safely and efficiently.

Phage therapy offers a promising approach to combat the growing threat of antimicrobial resistance. Yet, key questions remain regarding dosage, administration routes, combination therapy, and the causes of therapeutic failure. In this study, we focused on a novel lytic phage, ФAb4B, which specifically targeted the Acinetobacter baumannii strains with KL160 capsular polysaccharide, including the pan-drug resistant A.

A microbial knowledge graph-based deep learning model for predicting candidate microbes for target hosts.

Predicting interactions between microbes and hosts plays critical roles in microbiome population genetics and microbial ecology and evolution. How to systematically characterize the sophisticated mechanisms and signal interplay between microbes and hosts is a significant challenge for global health risks. Identifying microbe-host interactions (MHIs) can not only provide helpful insights into their fundamental regulatory mechanisms, but also facilitate the development of targeted therapies for microbial infections.

Advance on Engineering of Bacteriophages by Synthetic Biology.

Since bacteriophages (phages) were firstly reported at the beginning of the 20th century, the study on them experiences booming-fading-emerging with discovery and overuse of antibiotics. Although they are the hotspots for therapy of antibiotic-resistant strains nowadays, natural phage applications encounter some challenges such as limited host range and bacterial resistance to phages. Synthetic biology, one of the most dramatic directions in the recent 20-years study of microbiology, has generated numerous methods and tools and has contributed a lot to understanding phage evolution, engineering modification, and controlling phage-bacteria interactions.

ApoE Mimetic Peptide COG1410 Exhibits Strong Additive Interaction with Antibiotics Against .

Background: Drug-resistant tuberculosis (TB) is an emerging threat to public health worldwide. Antimicrobial peptide (AMP) is a promising solution to solve the antimicrobial resistance crisis. The apolipoprotein E mimetic peptide COG1410 has been confirmed to simultaneously have neuroprotective, anti-inflammatory, and antibacterial activity.

Where is the limit for overtime? Impacts of overtime on employees' mental health and potential solutions: A qualitative study in China.

Although Labor Law of the People's Republic of China stipulates the overtime system, overtime is still widespread in the IT industry. Through qualitative interviews, we explored the impact of overtime on employees' mental health and life. The current study identified four main themes, namely overtime reasons, outcomes of overtime, influential factors and solutions to overtime challenges.

Urgency of controlling agricultural nitrogen sources to alleviate summertime air pollution in the North China Plain.

Agricultural nitrogen sources (ANS) have played an increasingly important role in the air quality since ANS emission controls are much weaker than those for fossil fuel combustion sources due to the increasing food demand. However, ANS emissions are highly uncertain due to stochastic agricultural management activities and limited field measurements, and impacts of ANS on the air quality remain elusive. In the study, the WRF-Chem model has been used to investigate ANS shares in near surface air pollutant concentrations during a growing season in the North China Plain (NCP), with ANS emissions constrained by satellite retrievals.

The predictive performance of the lactate clearance rate combined with the APACHE II score in the prediction of sepsis-associated acute kidney injury in 7 days.

Background: The purpose of this study was to evaluate the accuracy of the lactate clearance rate (LCR) combined with the Acute Physiology and Chronic Health Evaluation II (APACHE II) score in the prediction of sepsis-associated acute kidney injury (SAKI).

Methods: Sepsis patients were divided into the SAKI group and non-SAKI group. Arterial blood lactate was collected at 0 h (before treatment), 2 h, 4 h, 6 h, and 8 h (after treatment), and the LCR was calculated.

The Effect of Worktime Control on Overtime Employees' Mental Health and Work-Family Conflict: The Mediating Role of Voluntary Overtime.

Overtime has become a widespread phenomenon in the current information age that creates a high speed working pace and fierce competition in the high technology global economy. Based on the time-regulation mechanism and effort-recovery model, we examined the effect of worktime control (WTC) on mental health and work-family conflict (WFC) among overtime employees, and whether voluntary overtime mediated the relationships. We also examined two separate dimensions of WTC (control over time-off and control over daily hours).

Effects of hydroperoxy radical heterogeneous loss on the summertime ozone formation in the North China Plain.

Hydroperoxy radical (HO) is a crucial oxidant participating in the oxidation of nitrogen oxide to nitrogen dioxide which constitutes one of the most important pathways for the ozone (O) photochemical formation in the troposphere. Laboratory experiments and field observations have revealed efficient HO heterogeneous uptake on wet aerosols, but its impact on the O formation remains controversial. A severe and persistent O pollution episode has been simulated using the WRF-Chem model to evaluate the impacts of the HO heterogeneous loss on the O formation in the North China Plain (NCP) during the summertime of 2018.

Cropland nitrogen dioxide emissions and effects on the ozone pollution in the North China plain.

Soil nitrogen dioxide (NO = NO + NO) emissions have been measured and estimated to be the second most significant contributor to the NO burden following the fossil fuel combustion source globally. NO emissions from croplands are subject to being underestimated or overlooked in air pollution simulations of regional atmospheric chemistry models. With constraints of ground and space observations of NO, the WRF-Chem model is used to investigate the cropland NO emission and its contribution to the near-surface ozone (O) pollution in North China Plain (NCP) during a growing season as a case study.

Homozygous spinocerebellar ataxia type 3 in China: a case report.

Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease caused by a heterozygous CAG repeat expansion in the ataxin 3 gene (). However, patients with homozygous SCA3 carrying expanded CAG repeats in both alleles of are extremely rare. Herein, we present a case of a 50-year-old female who had homozygous SCA3 with expansion of 62/62 repeats.

Seasonal fluctuations in symbiotic bacteria and their role in environmental adaptation of the scleractinian coral Acropora pruinosa in high-latitude coral reef area of the South China Sea.

Coral-associated bacterial communities are paramount for coral ecosystems and holobiont health. However, the role of symbiotic bacteria in the adaptation of high-latitude corals to seasonal fluctuations remains underexplored. Therefore, we used 16S rRNA-based high-throughput sequencing to analyze the symbiotic bacterial diversity, composition, and core bacterial community in high-latitude coral and explored the seasonal fluctuation characteristics of symbiotic bacterial communities.

MiR-106a aggravates sepsis-induced acute kidney injury by targeting THBS2 in mice model.

Purpose: To investigate the role and related mechanisms of miR-106a in sepsis-induced AKI.

Methods: Serum from sepsis and healthy patients was collected, sepsis mouse model was established by cecal ligation and puncture (CLP). TCMK-1 cells were treated with lipopolysaccharide (LPS) and transfected with THBS2-small interfering RNA (siTHBS2), miR-106a inhibitor, miR-106a mimics and their negative controls (NCs).