Molecular mechanisms of DNase inhibition of early biofilm formation or : A transcriptome analysis.

studies show that DNase can inhibit and biofilm formation. However, the underlying molecular mechanisms remain poorly understood. This study used an RNA-sequencing transcriptomic approach to investigate the mechanism by which DNase I inhibits early and biofilm formation on a transcriptional level, respectively.

Superoxide dismutase A (SodA) is a c-di-GMP effector protein governing oxidative stress tolerance in Stenotrophomonas maltophilia.

C-di-GMP is a bacterial second messenger implicated in the regulation of many key functions including antibiotic tolerance and biofilm formation. Our understanding of how c-di-GMP exerts its action via receptors to modulate different biological functions is still limited. Here we used a c-di-GMP affinity pull-down assay coupled to LC-MS/MS to identify c-di-GMP-binding proteins in the opportunistic pathogen Stenotrophomonas maltophilia.

Metagenomic Next-Generation Sequencing Assists in the Diagnosis of Mediastinal Abscess in an Immunocompetent Patient: A Case Report and Literature Review.

Background: is an opportunistic fungal pathogen, which is commonly found in lungs and rarely causes infections in mediastinum. Mediastinal abscess is a serious infectious condition, and is characterized by difficult diagnosis due to its clinical manifestations being nonspecific.

Case Presentation: Here, we report a case of a mediastinal abscess in an immunocompetent patient.