A multicenter study of neurofibromatosis type 1 utilizing deep learning for whole body tumor identification.

Deep-learning models have shown promise in differentiating between benign and malignant lesions. Previous studies have primarily focused on specific anatomical regions, overlooking tumors occurring throughout the body with highly heterogeneous whole-body backgrounds. Using neurofibromatosis type 1 (NF1) as an example, this study developed highly accurate MRI-based deep-learning models for the early automated screening of malignant peripheral nerve sheath tumors (MPNSTs) against complex whole-body background.

Biomechanical evaluation of the modified proximal femoral nail for the treatment of reverse obliquity intertrochanteric fractures.

The best treatment method for reverse obliquity intertrochanteric fractures (ROIFs) is still under debate. Our team designed the modified proximal femoral nail (MPFN) specially for treating such fractures. The objective of this research was to introduce the MPFN device and compare the biomechanical properties with Proximal Femoral Nail Antirotation (PFNA) and InterTAN nail via finite element modelling.

Gold nanorod in silver tetrahedron: Cysteamine mediated synthesis of SERS probes with embedded internal markers for AFP detection.

Background: Plasmonic core-shell nanostructures with embedded internal markers used as Raman probes have attracted great attention in surface-enhanced Raman scattering (SERS) immunoassay for cancer biomarkers due to their excellent uniform enhancement. However, current core-shell nanostructures typically exhibit a spherical shape and are coated with a gold shell, resulting in constrained local field enhancement.

Results: In this work, we prepared a core-shell AuNR@BDT@Ag structure by depositing silver on the surface of Raman reporter-modified gold nanorods (AuNR).

IdenHerb: A strategy for identifying constitutive herbs of herbal products by screening exclusive ions of each herb from large-scale multi-group LC-MS data.

Identification of constitutive herbs in an herbal product is critical for ensuring its quality and efficacy. However, current identification methods often lack universality, entail long durations, and involve complex procedures. Therefore, there is an urgent need to develop innovative methods for identifying constitutive herbs.

Associations between domestic hard water exposure and incident psoriasis in adults: Insights from the UK Biobank cohort study.

Although exposure to hard water is associated with various inflammatory skin conditions, the specific relationship between hard water and psoriasis has not been clearly defined. We analyzed data from 486,414 participants in the UK Biobank cohort to explore the association between domestic hard water exposure and the incidence of psoriasis. Domestic water hardness, measured in calcium carbonate concentration, was obtained in 2005 from local water providers in Wales, Scotland, and England.

Ambient coarse particulate matter pollution and hospital admissions for schizophrenia.

Objective: To investigate the association between ambient coarse particulate matter (PM) pollution and risk of acute schizophrenia episodes.

Methods: A time-stratified case-crossover study with a two-stage analytical approach was conducted to investigate the association between ambient PM pollution and schizophrenia admissions (an indicator for acute schizophrenia episodes) across 259 Chinese cities of prefecture-level or above during 2013-2017. A conditional logistic regression model was constructed to estimate city-specific changes in hospital admissions for schizophrenia associated with per interquartile range (IQR) increase in ambient PM, and the overall associations were obtained by pooling the city-specific associations using the random-effects model.

The Association Between Egg and Egg-Derived Cholesterol Consumption, and Their Change Trajectories, with Obesity Among Chinese Adults: Results from the China Health and Nutrition Survey.

As a widely consumed, nutritious, and affordable food, eggs and their derivatives' impacts on obesity remain inconclusive. In this study, we aimed to determine the association between egg and egg-derived cholesterol consumption, and their change trajectories, with obesity among Chinese adults. : Longitudinal data collected by the China Health and Nutrition Survey from 1997 to 2015 were analyzed.

D-MGDCN-CLSTM: A Traffic Prediction Model Based on Multi-Graph Gated Convolution and Convolutional Long-Short-Term Memory.

Real-time and accurate traffic forecasting aids in traffic planning and design and helps to alleviate congestion. Addressing the negative impacts of partial data loss in traffic forecasting, and the challenge of simultaneously capturing short-term fluctuations and long-term trends, this paper presents a traffic forecasting model, D-MGDCN-CLSTM, based on Multi-Graph Gated Dilated Convolution and Conv-LSTM. The model uses the DTWN algorithm to fill in missing data.

Current Characteristics of REBCO Tapes in 6-Slot TSTC-CICC Under Bending Conditions.

Embedding stacked HTS tapes into twisted slots is one design approach for constructing fusion conductors. This paper adopts a Cable-in-Conduit Conductor (CICC) structure, utilizing commercially REBCO coated conductors. The cable framework is made of copper and features six helically twisted slots filled with 2G HTS tapes.

Expansion Characteristics and Shear Behavior of Reinforced Concrete Beams Under Non-Uniform Expansion Induced by Alkali-Silica Reaction.

Alkali-silica reaction (ASR) is an important factor that seriously affects the durability of reinforced concrete (RC) structures. The current research on alkali-aggregate mainly focuses on the deterioration mechanism of materials and the mechanical properties of standard specimens. However, there is a gap in the field of research on the effect of alkali-aggregate damage on the level of RC structures.

A Compact Broadband Common-Aperture Dual-Polarized Antenna for Drone Applications.

A novel common-aperture miniaturized antenna with wideband and dual-polarized characteristics is proposed, which consists of a circularly polarized (CP) and a linearly polarized (LP) antenna. The circularly polarized antenna stacked on the upper layer adopts asymmetrical ground and introduces the patch and T-type feed network. On this basis, the meshed reflector structure, which also works as a ground plane for the LP antenna, is added to reduce the influence on circular polarization and achieve directional radiation.

Ecological and Functional Changes in the Hindgut Microbiome of Holstein Cows at High Altitudes.

The extreme environmental conditions of the Qinhai-Tibetan Plateau (QTP) challenge livestock survival and productivity, yet little is known about how high-altitude environments impact the gut microbiota of dairy cows. To fill this gap, we systematically investigated the differences in the hindgut microbiome between 87 plateau Holstein cows and 72 plain Holstein cows using 16S rRNA gene sequencing. Our analysis revealed that the hindgut microbiota of the plateau group exhibited lower species richness but higher evenness than that in the plain group.

Quality of life among healthcare workers in the hospitals and primary healthcare centers in Gaza Strip: a cross-sectional study.

Background: Quality of life (QoL) is an important measure of overall well-being linked to physical, mental, social, and environmental aspects of health. This study aimed to assess the QoL among healthcare workers (HCWs) in hospitals and primary healthcare centers (PHCs) in Gaza Strip, Palestine.

Methods: A cross-sectional study was conducted among 1850 HCWs in Gaza Strip, Palestine.

GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway.

Background: Ovarian cancer (OC) progression is one of the commonest cause of female cancer death. While treatments in clinic includes primary surgery and targeted chemotherapy, curative and survival trends in OC have not significantly improved. Thus, further investigation of the mechanisms regarding OC carcinogenesis and discovery of novel targets is of great importance.

Cross-cultural insights into internet addiction and mental health: a network analysis from China and Malawi.

Background: Internet addiction has emerged as a significant mental health issue among university students. The study aimed to compare the network structures of Internet addiction and mental health symptoms among university students in China and Malawi, which provide insights into culturally sensitive prevention and intervention strategies.

Methods: Network analysis was used on two datasets: Malawi (n = 688) and China (n = 975) using the Internet Addiction Test and the Self-Reporting Questionnaire.

Guillain-Barré syndrome in patients with multiple myeloma: three cases report and literature review.

Background: Multiple myeloma (MM) with Guillain-Barré syndrome (GBS) is relatively rare, and the specific mechanism is still unclear. The previous infection, surgery, and medication use may have contributed to the occurrence of GBS. The use of bortezomib in patients with MM can easily lead to peripheral neuropathy, which is similar to the symptoms of GBS, making it challenging to diagnose GBS.

Deformation behavior of additive manufactured 316 L stainless steel using in situ neutron diffraction.

Manufacturing of metallic components using additive manufacturing technique is of great interest for the industrial applications. Here, the mechanical and microstructural responses of a 316 L stainless steel (316LSS) built by selective laser melting (SLM) with XOY and XOZ directions were revealed by performing in situ neutron diffraction tensile tests. The tensile strength of the XOY-printed samples reaches 700 MPa, while the tensile strength of the XOZ-printed samples is less than 600 MPa.

Acoustic emission characteristics and damage constitutive model of fractured sandstone under uniaxial compression.

To investigate the statistical laws of acoustic emission energy (AEE) avalanche dynamics of sandstone under varying fracture lengths and dip angles, as well as to determine the relationship between acoustic emission (AE) parameters and damage variables, we studied the mechanical properties and AE characteristics of sandstone with a single fracture subjected to uniaxial compression with the aid of the Shimadzu AG-IS test system and the PCI-2 AE system. The AEE characteristics of fractured sandstone under load were analyzed based on the statistical method of avalanche dynamics, with emphasis on AEE distribution, aftershock sequence, and waiting time distribution. The Weibull distribution function that incorporates a correction coefficient β was employed to optimize the Weibull parameters based on the strain equivalent hypothesis theory, which led to the establishment of a statistical damage constitutive model for fractured rock.

A study on critical dislocation of gasket for segmental linings of shield tunnels.

Dislocation of segments in shield tunnels significantly contributes to joint leakage, making it crucial to identify the critical dislocation amount of segment linings. To explore the waterproofing mechanism of sealing gaskets under water pressure, a structural coupling finite element analysis model was created. This model simulates water intrusion dynamics at segment joints, analyzing contact stress distribution and waterproof performance across various dislocation amounts.

Rapid and sensitive detection of exosomal microRNAs by terahertz metamaterials.

Exosomal microRNAs (miRNAs) are among the most common biomarkers for tumor diagnosis. However, single-miRNA detection lacks ideal sensitivity and specificity for diagnosing a certain tumor in clinics. In this work, we fabricated a convenient multi-miRNA detection platform for sensitive and specific detection on exosomal miRNAs in the plasma of patients using a terahertz (THz) metamaterial biosensor on the basis of strand displacement amplification (SDA) and AuNPs.

Identification of hypertension gene expression biomarkers based on the DeepGCFS algorithm.

Hypertension is a critical risk factor and cause of mortality in cardiovascular diseases, and it remains a global public health issue. Therefore, understanding its mechanisms is essential for treating and preventing hypertension. Gene expression data is an important source for obtaining hypertension biomarkers.

Regulating Charge Distribution in Porphyrin-Based Polymer for Achieving Photocatalytic CO Conversion to CH or CH.

The photocatalytic conversion of CO into products such as CH and CH poses a significant challenge due to the lengthy reaction steps and the high energy barrier involved. In this study, both benzothiadiazole (BTD) and hydroxyl groups (-OH) are introduced into cobalt-based polymerized porphyrinic network (PPN) through a C-C coupling reaction. This modification of orbital energy levels that strengthens the ability of gain electrons and facilitates the charge transfer in PPN.

Internal Nanocavity Regulation of Embedded Rare Earth Up-Conversion Nanoparticles for HO Production Operable at Up to 780 nm.

Semiconductor photocatalysts embedded with rare earth upconversion nanoparticles (REUPs) are a promising strategy to improve their photoresponse range, but their photocatalytic performance within the near-infrared (NIR) region is far from satisfactory. Here, a method is reported to improve the photocatalytic activity by adjusting the nanocavity of upconversion nanoparticles inside a semiconductor. Two types of CdS embedded with NaYF:Yb,Er photocatalysts with core-shell structure (no cavity) (NYE/CdS) and yolk-shell structure (empty cavity) (NYE@CdS) are synthesized by different methods.

Cervical cancer incidence rates considering migration status in mainland China using Bayesian model-Estimation based on 2016 cancer registry data.

In mainland China, cancer registration relies on household-registered populations, overlooking migrant populations. Estimating cervical cancer incidence among permanent residents, including migrants, offers a more accurate representation of the true burden. The data from 487 cancer registries across China in 2016 were analyzed using a Bayesian spatial regression model with the integrated nested Laplace approximation-stochastic partial differential equation method.