Human immunodeficiency virus type 1 transcription is regulated by thieno[3,4- ]pyrimidine.

In the present study, the effect of thieno[3,4-]pyrimidine (TEP) on the transcription of human immunodeficiency virus type 1 (HIV-1) was investigated. To the best of the authors' knowledge, this is the first study describing the effect of TEP on the transcription of HIV-1. The present results identified a marked decrease in the production of the HIV-1 genome in 293T cells after treatment with TEP.