Ischemic postconditioning reduces spinal cord ischemia-reperfusion injury through ATP-sensitive potassium channel.

Study Design: Animal study.

Objectives: Explore the neuroprotective effect of remote limb ischemic postconditioning (Post C) in spinal cord ischemic reperfusion injury (SCII) and related mechanisms.

Setting: Anesthesiology Laboratory of Southwest Medical University.

Activation of SK3 channel plays a pivotal role in modulation of trigeminal neuralgia.

To investigate whether small conductance Ca activated channels; Trigeminal ganglion; Trigeminal neuralgia. (SK3) exists in normal rats' trigeminal ganglions (TG) and its effect on their pain thresholds. In total, 110 healthy adult male Sprague-Dawley (SD) rats were involved in this study.

c-Abl-p38 signaling pathway mediates dopamine neuron loss in trigeminal neuralgia.

Trigeminal neuralgia is a common neuropathic pain in the head and face. The pathogenesis of trigeminal neuralgia is complex, and so far, the pathogenesis of trigeminal neuralgia involving peripheral and central nervous inflammation theory has not been explained clearly. The loss of dopamine neurons in striatum may play an important role in the development of trigeminal nerve, but the reason is not clear.