Lipase activated endocytosis-like behavior of oil-in-water emulsion.

Oil-in-water emulsion is a system with extensive applications in foods, cosmetics and coating industries, and it could also be designed into an artificial lipid droplet in recent works. However, the insights into the biophysical dynamic behaviors of such artificial lipid droplets are lacking. Here, we reveal an enzymatic reaction triggered endocytosis-like behavior in the oil-in-water emulsion lipid droplets.

Interleukin-41: a novel serum marker for the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma.

Background: For the lack of effective serum markers for hepatocellular carcinoma(HCC) diagnosis, it is difficult to detect liver cancer and identify its recurrence early.

Methods: Databases were used to analyze the genes potentially associated with alpha-fetoprotein(AFP). ELISA assay was used to detect the serum IL-41 in HCC, liver metastases, hepatitis, and healthy people.

Exosomal miR-19a decreases insulin production by targeting Neurod1 in pancreatic cancer associated diabetes.

Background: New onset diabetes mellitus demonstrates a roughly correlation with pancreatic cancer (PaC), which is unique in PaC and was named as PaC-induced DM, but the inner mechanism remains unclear. Exosomes mediate intercellular communication and bearing microRNAs might be direct constituent of effect in target cells.

Methods And Results: The isolated exosomes from PaC cells were used to treat pancreatic β cells or the primary mice islets, and the glucose stimulated insulin secretions were measured.

Smoothing Complete Feature Pyramid Networks for Roll Mark Detection of Steel Strips.

Steel strip acts as a fundamental material for the steel industry. Surface defects threaten the steel quality and cause substantial economic and reputation losses. Roll marks, always occurring periodically in a large area, are put on the top of the list of the most serious defects by steel mills.

Near-Infrared-Induced Contractile Proteinosome Microreactor with a Fast Control on Enzymatic Reactions.

Inspired by the compartmentalized structure of cells, self-regulating responsive hollow microcapsules are highly desirable for the modulation of enzymatic reactions. Here, we report a strategy to fabricate gold nanorod embedded proteinosomes by covalently grafting gold nanorods onto the surface of proteinosomes. The excellent photothermal conversion efficiency of the embedded gold nanorod and the thermal phase transition of the grafted PNIPAAm allow the constructed hybrid proteinosomes to show reversible contraction behaviors triggered by near-infrared light with the molecular weight cutoff of the membrane decreased to ca.

Facile Synthesis of Super-Microporous Titania-Alumina with Tailored Framework Properties.

Super-microporous material (pore size 1-2 nm) can bridge the pore size gap between the zeolites (<1 nm) and the mesoporous oxides (>2 nm). A series of super-microporous titania-alumina materials has been successfully prepared via a facile one-pot evaporation-induced self-assembly (EISA) strategy by different solvents using fatty alcohol polyoxyethylene ether (AEO-7) as the template. Moreover, no extra acid or base is added in our synthesis process.

Interfacial self-assembly of gold nanoparticle-polymer nanoconjugates into microcapsules with near-infrared light modulated biphasic catalysis efficiency.

A high throughput way to generate gold nanoparticle-based microcapsules was demonstrated based on the interfacial assembly in a water and 2-ethyl-1-hexanol two phase system. The obtained gold microcapsules exhibit superior stability, good flexibility, ductility, and a significant enhancement (about 10-fold) in the biphasic catalytic reaction rate upon near-infrared light irradiation.

Integrative Analysis of MicroRNAome, Transcriptome, and Proteome during the Limb Regeneration of Cynops orientalis.

Salamanders completely regenerate their limbs after amputation. Thus, these animals are unique models to investigate the mechanisms modulating regeneration in vertebrates. To investigate the influence of microRNAs (miRNAs) on newt limb regeneration, the miRNAs and mRNAs were simultaneously profiled using Illumina HiSeq 2500 System during limb regeneration of Cynops orientalis at 3, 7, 14, 30 and 42 days postamputation.

Signal-On Electrochemiluminescence of Self-Ordered Molybdenum Oxynitride Nanotube Arrays for Label-Free Cytosensing.

In this paper, a signal-on electrochemiluminescence (ECL) cytosensing platform was developed based on nitrogen doped molybdenum oxynitride nanotube arrays (MoO N NTs) for the first time. The MoO N NTs exhibited excellent cathodic ECL behavior with 2-(dibutylamino)-ethanol (DBAE) as a coreactant. Owing to the surface plasmon resonance (SPR) of Au triggered by the ECL emission, the generation of "hot electrons" on AuNPs hampered DBAE to give off electrons and leads to the ECL quenching.

MicroRNA-148a Suppresses the Proliferation and Migration of Pancreatic Cancer Cells by Down-regulating ErbB3.

Objectives: ErbB3 (HER3) has been associated with pancreatic cancer progression, but little is known about its regulatory mechanisms. We investigated whether microRNAs (miRNAs) regulate levels of ErbB3 in pancreatic cancer cells.

Methods: We used bioinformatic analyses to search for miRNAs that can potentially target ERBB3.

Brachybacterium hainanense sp. nov., isolated from noni (Morinda citrifolia L.) branch.

A Gram-stain-positive bacterial strain, designated as NR2T, isolated from noni (Morinda citrifolia L.) branch was investigated using a polyphasic taxonomic approach. The cells were small coccoid to ovoid, non-spore-forming and motile.

Pancreatic cancer-secreted miR-155 implicates in the conversion from normal fibroblasts to cancer-associated fibroblasts.

Cancer-associated fibroblasts (CAF) are a major constituent of the pancreatic cancer microenvironment and that the meaning is as intended. Pancreatic cancer cells can induce normal fibroblasts to convert into CAF and, reciprocally, CAF promote tumor invasions and proliferations. The mechanism of the conversion from normal fibroblasts (NF) to CAF remains unclear.

Sphingomonas morindae sp. nov., isolated from Noni (Morinda citrifolia L.) branch.

Two yellow bacterial strains, designated NBD5(T) and NBD8, isolated from Noni (Morinda citrifolia L.) branch were investigated using a polyphasic taxonomic approach. Cells were Gram-stain-negative, aerobic, non-spore-forming, non-motile and short rod-shaped.

MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal cancer.

Insulin-like growth factor 1 receptor (IGF1R) is a transmembrane receptor that is activated by insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors and plays an important role in colorectal cancer etiology and progression. In this study, we used bioinformatic analyses to search for miRNAs that potentially target IGF1R.