A study of changes in hematologic parameters in patients with migraine.

Introduction: To evaluate the characteristics of hematological parameters and peripheral inflammatory markers in migraine, including chronic migraine (CM) and episodic migraine (EM), and to explore their underlying mechanisms.

Method: A total of 88 subjects were enrolled, 58 with migraine (28 with chronic migraine and 30 with episodic migraine) and 30 healthy controls. All subjects were matched for age, gender and body mass index (BMI), and peripheral blood was collected.

The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity.

Aims: To investigate whether insula network connectivity modulates the relationship between apolipoprotein E (APOE) ε4 genotype, cerebrospinal fluid (CSF) biomarkers (Aβ, Tau, and pTau) and cognition across Alzheimer's disease (AD) spectrum.

Methods: Forty-six cognitive normal (CN), 35 subjective memory complaint (SMC), 41 mild cognitive impairment (MCI), and 32 AD subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were obtained. Multivariable linear regression analyses were conducted to investigate the main effects and interaction of the APOE genotype and disease status on the insula functional connectivity (IFC) network.

Interictal Activity Is Associated With Slower Binocular Rivalry in Idiopathic Generalized Epilepsy.

Perceptual alternations evoked by binocular rivalry (BR) reflect cortical dynamics strongly dependent on the excitatory-inhibitory balance, suggesting potential utility as a biomarker for epileptogenesis. Therefore, we investigated the characteristics of BR in patients with idiopathic generalized epilepsy (IGE) and potential associations with clinical variables. Sixty-two healthy controls (HCs) and 94 IGE patients completed BR task.

TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage.

Neuroinflammation contributes to the pathogenesis of early brain injury induced by subarachnoid hemorrhage (SAH). Previous reports have demonstrated that triggering receptor expressed on myeloid cells 1 (TREM-1) regulates inflammatory response caused by ischemic stroke or myocardial infarction. However, whether TREM-1 could modulate neuroinflammation after SAH remains largely unknown.

The Working Memory and Dorsolateral Prefrontal-Hippocampal Functional Connectivity Changes in Long-Term Survival Breast Cancer Patients Treated with Tamoxifen.

Background: Tamoxifen is the most widely used drug for treating patients with estrogen receptor-sensitive breast cancer. There is evidence that breast cancer patients treated with tamoxifen exhibit cognitive dysfunction. However, the underlying neural mechanism remains unclear.

Moral judgment in patients with idiopathic generalized epilepsy.

Purpose: The aim of the current study was to investigate morality while also investigating frontal lobe function with the goal of studying the relationship between frontal lobe and morality in patients with idiopathic generalized epilepsy.

Method: A total of 23 right-handed patients with IGE and 25 right-handed healthy participants agreed to participate. Participants made judgments on a series of 50 hypothetical scenarios, which were adapted from a previously published set.