Publications by authors named "Jiao-Lan Li"
Objective: To observe the effect of "Neiguan" (PC6)-electroacupuncture (EA) preconditioning on serum metabolites in myocardial ischemia-reperfusion injury (MIRI) rats, so as to reveal its mechanism underlying improvement of ischemic myocardium from metabonomics.
Methods: A total of 48 male SD rats were randomly divided into control, model, EA "Neiguan"(PC6) and EA "Hegu"(LI4) groups (＝12 rats/ group). Rats of the control group were just banded on animal boards for 30 min, once daily for 7 days.
Objective: To observe the effect of "Neiguan" (PC6)-electroacupuncture (EA) or moxibustion (Moxi) pretreatment on myocardial apoptosis and expression of autophagy related proteins light chain (LC) 3-Ⅰ and LC3-Ⅱ in rats with myocardial ischemia/reperfusion injury (MIRI), so as to explore their mechanisms underlying improvement of MIRI.
Methods: Forty SD rats (half male and half female) were randomly divided into sham operation, model, ischemic preconditioning (IP), EA and Moxi groups (＝8 in each group). EA (10 Hz/50 Hz, 1 mA) or Moxi (ignited moxa stick) was respectively applied to bilateral "Neiguan" (PC6) for 20 min, once daily for 7 days.
[Effect of Electroacupuncture at "Neiguan"(PC 6) on Serum and Myocardial Metabolites in Rats with Myocardial Ischemia Reperfusion Injury Based on Nuclear Magnetic Resonance Spectroscopy].
Zhen Ci Yan Jiu
March 2018
Objective: We have repeatedly demonstrated that electroacupuncture (EA) of "Neiguan"(PC 6) can improve myocardial ischemia in rats. The present study was designed to investigate the metabolomic profile of peripheral blood se-rum and myocardium involving EA-induced improvement of myocardial ischemia-reperfusion injury (MIRI) in rats by using nuclear magnetic resonance spectroscopy.
Methods: Thirty male SD rats were equally randomized into blank control, model and EA groups.
Article Synopsis
- The study aimed to investigate how electroacupuncture (EA) and moxibustion (Moxi) affect heart damage and related protein expressions in rats suffering from myocardial ischemia-reperfusion injury (MI/RI).
- Rats were divided into different treatment groups, with EA or Moxi applied daily for 7 days before inducing MI/RI through artery blockage.
- Post-treatment analysis showed improved heart structure and reduced cell damage in the EA and Moxi groups, along with significant changes in autophagy-related proteins, suggesting these methods may help mitigate heart injury.