Publications by authors named "Jiao-Jiao Xi"
Article Synopsis
- Down syndrome (DS) is primarily characterized by mental retardation, with neural abnormalities starting early in embryonic development and persisting throughout life.*
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- The Tc1 mouse model, which has a significant portion of human chromosome 21, shows multiple neurological issues similar to those found in DS patients and was used to study early neural abnormalities.*
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- Research revealed hypermethylation in Tc1 induced pluripotent stem (iPS) cells, leading to abnormal gene expression linked to neurodevelopment, suggesting that these methylation changes contribute to nervous system issues in DS.*
