Explore the effect of LLY-283 on the ototoxicity of auditory cells caused by cisplatin: A bioinformatic analysis based on RNA-seq.

Background: Cisplatin is a commonly used chemotherapeutic drug in clinics, and long-term application will lead to hearing impairment. LLY-283, an inhibitor of PRMT5, has not been reported in deafness. Our study aimed to explore the mechanism of LLY-283 in hearing impairment.

Web-based transcriptome analysis determines a sixteen-gene signature and associated drugs on hearing loss patients: A bioinformatics approach.

Background: Hearing loss is becoming more and more general. It may occur at all age and affect the language learning ability of children and trigger serious social problems.

Methods: The hearing loss differentially expressed genes (HL-DEGs) were recognized through a comparison with healthy subjects.

Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase.

Background: The high expression of BLM (Bloom syndrome) helicase in tumors involves its strong association with cell expansion. Bisbenzylisoquinoline alkaloids own an antitumor property and have developed as candidates for anticancer drugs. This paper aimed to screen potential antiproliferative small molecules from 12 small molecules (the derivatives of bisbenzylisoquinoline alkaloids tetrandrine and fangchinoline) by targeting BLM helicase.

Effects of Angle of Epiglottis on Aerodynamic and Acoustic Parameters in Excised Canine Larynges.

Objectives: The aim of this study is to explore the effects of the angle of epiglottis (Aepi) on phonation and resonance in excised canine larynges.

Methods: The anatomic Aepi was measured for 14 excised canine larynges as a control. Then, the Aepis were manually adjusted to 60° and 90° in each larynx.

Study on Normal Laryngeal Electromyography of Thyroarytenoid Muscle, Cricothyroid Muscle, and Posterior Cricoarytenoid Muscle.

Objective: The aim of this study was to investigate the physiological activity of intrinsic laryngeal muscle under different functional states of larynx by measuring the normal laryngeal electromyography parameters.

Methods: Laryngeal electromyography (EMG) was performed in 112 patients with unilateral vocal cord movement disorder. The duration and amplitude of the motor unit potential (MUP) of the thyroarytenoid muscle (TA), posterior cricoarytenoid muscle (PCA), and cricothyroid muscle (CT) were measured when patients were asked to make a deep inspiration and phonate /i/.

Establishment and Analysis of False Vocal Folds Hypertrophy Model in Excised Canine Larynges.

Objective: This study aimed to investigate the role of false vocal folds (FVFs) medialization in phonation and the acoustic impact of ventricular hypertrophy by establishing an FVF hypertrophy model.

Study Design: A prospective in vitro experiment was carried out.

Setting: The study was carried out using a pseudolung platform with high-speed camera in a soundproof room.

[Duplex real-time PCR assay for rapid detection of E. coli O157 and E. coli O104 in the legume plants and its products].

Objective: To establish a rapid assay to detect enterohemorrhagic Escherichia coli O157 (E. coli O157) and enterohemorrhagic Escherichia coli O104 (E. coli O104) in the legume plants and its products by using the duplex real-time PCR.

[Significance of certain experiments relevant to airflow parameters in assessment of voice function].

Objective: To investigate the role of airflow parameters of some specific examinations in voice function assessment.

Methods: The s/z ratio, pulmonary function and phonatory aerodynamic parameters were measured in subjects with benign vocal fold lesions and with normal voice. The effect of treatment in subjects with benign vocal fold lesions was evaluated with the phonatory aerodynamic parameters.

Synergistic effect of interfacial lattice Ag(+) and Ag(0) clusters in enhancing the photocatalytic performance of TiO2.

An interfacial lattice Ag(+) doped on TiO2 (Ag(+)/TiO2) was prepared by eluting Ag(0) clusters from a hydrothermally prepared Ag(0)/Ag(+)/TiO2 composite. An Ag(+)/TiO2@Ag(0) composite photocatalyst was subsequently obtained via a secondary Ag(0) clusters loading process to the Ag(+)/TiO2. The photocatalytic activity of Ag(+)/TiO2@Ag(0) was greatly improved compared to Ag(0)/Ag(+)/TiO2 and Ag(+)/TiO2.