The active layer soils of Greenlandic permafrost areas can function as important sinks for volatile organic compounds.

Permafrost is a considerable carbon reservoir harboring up to 1700 petagrams of carbon accumulated over millennia, which can be mobilized as permafrost thaws under global warming. Recent studies have highlighted that a fraction of this carbon can be transformed to atmospheric volatile organic compounds, which can affect the atmospheric oxidizing capacity and contribute to the formation of secondary organic aerosols. In this study, active layer soils from the seasonally unfrozen layer above the permafrost were collected from two distinct locations of the Greenlandic permafrost and incubated to explore their roles in the soil-atmosphere exchange of volatile organic compounds.

High paracrine activity of hADSCs cartilage microtissues inhibits extracellular matrix degradation and promotes cartilage regeneration.

Due to its unique structure, articular cartilage has limited self-repair capacity. Microtissues are tiny tissue clusters that can mimic the function of target organs or tissues. Using cells alone for microtissue construction often results in the formation of necrotic cores.

Mechanically Resilient and Highly Efficient Flexible Perovskite Solar Cells with Octylammonium Acetate for Surface Adhesion and Stress Relief.

Flexible perovskite solar cells (FPSCs) have advanced significantly because of their excellent power-per-weight performance and affordable manufacturing costs. The unsatisfactory efficiency and mechanical stability of FPSCs are bottleneck challenges that limit their application. Here, we explore the use of octylammonium acetate (OAAc) with a long, intrinsic, flexible molecular chain on perovskite films for surface adhesion and mechanical releasing.

BE-43547A exerts hypoxia-selective inhibition on human pancreatic cancer cells through targeting eEF1A1 and disrupting its association with FoxO1.

Hypoxia is a key feature of the tumor microenvironment that leads to the failure of many chemotherapies and induces more aggressive and resistant cancer phenotypes. Up to date, there are very few compounds and treatments that can target hypoxia. BE-43547A from Streptomyces sp.

Microvascular blood flow ultrasound imaging with microbubble-based H-Scan technology.

Ultrasound blood flow imaging plays a crucial role in the diagnosis of cardiovascular and cerebrovascular diseases. Conventional ultrafast ultrasound plane-wave imaging techniques have limited capabilities in microvascular imaging. To enhance the quality of blood flow imaging, this study proposes a microbubble-based H-Scan ultrasound imaging technique.

Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification.

Mechanical stress modulates bone formation and organization of the extracellular matrix (ECM), the interaction of which affects heterotopic ossification (HO). However, the mechanically sensitive cell populations in HO and the underlying mechanism remain elusive. Here, we show that the mechanical protein Polysyctin-1 (PC1, Pkd1) regulates CTSK lineage tendon-derived mesenchymal stem cell (TDMSC) fate and ECM organization, thus affecting HO progression.

[Change trend of disease burden of chronic kidney disease mortality in Chongqing, 2012-2023].

To analyze change trend of disease burden of chronic kidney disease (CKD) mortality between 2012 and 2023 in Chongqing, and provide suggestion for CKD prevention. The mortality data of CKD were collected from Chongqing death registration between 2012 and 2023 according to International Classification of Diseases 10. The data were analyzed to calculate mortality rate, standardized mortality rate, age specific mortality rate, and the rate of years of life lost (YLL) and proportion by using software SPSS 26.

Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer.

Circular RNAs (circRNAs) have garnered substantial attention due to their distinctive circular structure and gene regulatory functions, establishing them as a significant class of functional non-coding RNAs in eukaryotes. Studies have demonstrated that circRNAs can interact with RNA-binding proteins (RBPs), which play crucial roles in tumorigenesis, metastasis, and drug response in cancer by influencing gene expression and altering the processes of tumor initiation and progression. This review aims to summarize the recent advances in research on circRNA-protein interactions (CPIs) and discuss the functions and mode of action of CPIs at various stages of gene expression, including transcription, splicing, translation, and post-translational modifications in the context of cancer.

A method of enhanced shear wave elastography based on Chirp coded excitation.

Shear Wave Elastography (SWE) is an imaging technique that detects shear waves generated by tissue excited by Acoustic Radiation Force (ARF), and characterizes the mechanical properties of soft tissue by analyzing the propagation velocity of shear wave. ARF induces a change in energy density through the nonlinear propagation of ultrasound waves, which drives the tissue to generate shear waves. However, the amplitude of shear waves generated by ARF is weak, and the shear waves are strongly attenuated in vivo.

Boron contributes to enhance antimony tolerance in rice (Oryza sativa L.) by activating antioxidant system, modifying the cell wall component and promoting cell wall deposition of Sb.

Boron (B) is essential for plant growth and helps mitigate metal toxicity in various crop plants. However, the potential role and underlying mechanisms of B in alleviating antimony (Sb) toxicity in rice remain unexplored. In this study, we investigated the effects of H₃BO₃ supplementation (30, 50, and 75 μM) on morphological growth, physiological and biochemical traits, Sb content, and the subcellular distribution of Sb in rice plants under 100 μM Sb stress during the seedling stage in a hydroponic system.

Disposal and resource utilization of oil-based drill cuttings in China - a review.

As a significant player in the global shale gas extraction industry, China has achieved a leading position in shale gas production on a worldwide scale. However, China is also facing the challenge of managing a considerable quantity of oil-based drill cuttings (OBDCs), which are classified as hazardous waste. Without appropriate treatment methods, these materials could cause significant environmental contamination.

Clinical characteristics of lymphoma patients presenting with fever of unknown origin misdiagnosed with connective tissue diseases.

Recognizing and diagnosing lymphoma in patients with fever of unknown origin (FUO) can be challenging, and misdiagnosis is not uncommon. To improve understanding of the clinical characteristics of lymphoma patients presenting with FUO who were misdiagnosed with autoimmune diseases. A retrospective, observational study of 140 consecutive patients with FUO and lymphoma presenting to a tertiary center between January 2017 and December 2023.

Phase I Dose Volume Escalation of Rectally Administered PC-1005 to Assess Safety, Pharmacokinetics, and Antiviral Pharmacodynamics as a Multipurpose Prevention Technology (MTN-037).

Background: On demand, topical PrEP is desired by those preferring episodic, nonsystemic PrEP. PC-1005 gel (MIV-150, zinc, and carrageenan) exhibits in vitro antiviral HIV-1, human papillomavirus (HPV), and herpes simplex virus type 2 (HSV-2) activity, attractive for a multipurpose prevention technology candidate. We evaluated the safety, pharmacokinetics, and antiviral effect of rectally applied PC-1005.

Glo-net: A dual task branch based neural network for multi-class glomeruli segmentation.

Accurate segmentation and classification of glomeruli are fundamental to histopathology slide analysis in renal pathology, which helps to characterize individual kidney disease. Accurate segmentation of glomeruli of different types faces two main challenges compared to traditional primitives segmentation in computational image analysis. Limited by small kernel size, traditional convolutional neural networks could hardly understand the complete context information of different glomeruli.

Association Between Serum Levels of Perfluoroalkyl and Polyfluoroalkyl Substances and Dental Floss Use: The Double-Edged Sword of Dental Floss Use-A Cross-Sectional Study.

Background: Although evidence suggests that dental floss contains perfluoroalkyl and polyfluoroalkyl substances (PFASs), it is still uncertain whether the use of dental floss contributes to an increased risk of PFAS exposure.

Methods: We analysed data on serum PFAS concentrations and dental floss usage in a cohort of 6750 adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2020. In our study, we used logistic regression, a survey-weighted linear model, item response theory (IRT) scores, inverse probability weights (IPWs) and sensitivity analysis to assess the potential impact of dental floss usage on human serum PFAS levels.

The Impact of Cooking on Antioxidant and Enzyme Activities in Ruichang Yam Polyphenols.

In this study, the total polyphenol content (TPC), total flavonoid content (TFC), and biological activity of yam polyphenols (including free phenolics, conjugated phenolics, and bound phenolics) were investigated during home cooking. Polyphenol components were preliminary detected in raw yam by HPLC, including 2, 4-dihydroxybenzoic acid, syringic acid, vanillic acid, 4-coumaric acid, and sinapic acid. TPC and TFC of soluble conjugated polyphenols were the main phenolic compounds in Ruichang yam.

Formation of Adaptive Trophic Niches of Euryphagous Fish Species in Response to Off-Seasonal Water Level Regulation in Hongze Lake.

Off-seasonal water level regulations disrupt the biological traits and phenological rhythms of native fish species, yet their impacts on interspecific trophic interactions remain understudied. This study employed stable isotope analysis to assess the trophic dynamics of three fish species (, , and ) across different water periods in Hongze Lake. The findings revealed that all three species occupied similar mid-level trophic positions, with no significant difference among water periods ( > 0.

Convergence analysis of deep Ritz method with over-parameterization.

The deep Ritz method (DRM) has recently been shown to be a simple and effective method for solving PDEs. However, the numerical analysis of DRM is still incomplete, especially why over-parameterized DRM works remains unknown. This paper presents the first convergence analysis of the over-parameterized DRM for second-order elliptic equations with Robin boundary conditions.

Association of Craniofacial Skeletal and Soft Tissue Characteristics With Severe Obstructive Sleep Apnea in Age-specific and BMI-specific Patient Groups.

Purpose: To identify the key craniofacial anatomic characteristics associated with the prevalence of severe obstructive sleep apnea (OSA) in patient cohorts stratified by age and body mass index (BMI).

Methods: This prospective study was conducted at the Beijing Anzhen Hospital Center for Sleep Medicine and Science between December 2023 and March 2024. Patients suspected of having OSA underwent overnight polysomnography, along with computed tomography scans of the head and neck, to evaluate the skeletal and soft tissue characteristics.

A Pyrene-Derived Fluorescent Probe for the Visual Detection of Protamine and Trypsin Activity.

A pyrene-derived fluorescent probe (P4CG) was designed and synthesized for the purpose of detecting protamine and trypsin activity. The anionic probe self-assembled with protamine, driven by electrostatic and hydrophobic interactions, exhibiting a sensing behavior towards protamine in a fluorescence ratiometric manner. The assay demonstrated high sensitivity, with a limit of detection (LOD) of 13.

A novel suture-free nephroplication with 4D-printed biodegradable bag for giant hydronephrosis: initial experience from hydromechanics and clinical application.

Background: Giant hydronephrosis as an rare condition is often caused by chronic ureteral obstruction. Nephroplication is a crucial procedure to improve urinary drainage in the kidney-sparing surgery for patients with giant hydronephrosis. However, traditional nephroplication via suturing kidney has technical difficulty and many potential risks.

A DNA origami-based enzymatic cascade nanoreactor for chemodynamic cancer therapy and activation of antitumor immunity.

Chemodynamic therapy (CDT) is a promising and potent therapeutic strategy for the treatment of cancer. We developed a DNA origami-based enzymatic cascade nanoreactor (DOECN) containing spatially well-organized Au nanoparticles and ferric oxide (FeO) nanoclusters for targeted delivery and inhibition of tumor cell growth. The DOECN can synergistically promote the generation of hydrogen peroxide (HO), consumption of glutathione, and creation of an acidic environment, thereby amplifying the Fenton-type reaction and producing abundant reactive oxygen species, such as hydroxyl radicals (•OH), for augmenting the CDT outcome.

Drug Delivery Across the Blood-Brain Barrier: A New Strategy for the Treatment of Neurological Diseases.

The blood-brain barrier (BBB) serves as a highly selective barrier between the blood and the central nervous system (CNS), and its main function is to protect the brain from foreign substances. This physiological property plays a crucial role in maintaining CNS homeostasis, but at the same time greatly limits the delivery of drug molecules to the CNS, thus posing a major challenge for the treatment of neurological diseases. Given that the high incidence and low cure rate of neurological diseases have become a global public health problem, the development of effective BBB penetration technologies is important for enhancing the efficiency of CNS drug delivery, reducing systemic toxicity, and improving the therapeutic outcomes of neurological diseases.

Predicting Tuberculosis Risk in Cattle, Buffaloes, Sheep, and Goats in China Based on Air Pollutants and Meteorological Factors.

Tuberculosis is a zoonotic chronic respiratory infectious disease caused by the complex. The outbreak and epidemic of tuberculosis can seriously threaten human and veterinary health. To investigate the effects of environmental factors on tuberculosis in domestic ruminants, we collected data regarding the prevalence of tuberculosis in cattle, buffaloes, sheep, and goats in China (1956-2024) from publicly published literature and available databases.