Ensemble predictions of high trophic-level fish distribution and species association in response to climate change in the coastal waters of China.

As climate change shifts marine ecosystems, understanding distribution changes of high trophic-level fish is critical for ecological and fisheries management. This study examined the distribution changes of five high trophic-level fish species in China's coastal waters from 1990 to 2023, using species distribution models (SDMs) combined in an ensemble modeling framework to predict future trends under RCP26 and RCP85 scenarios. The ensemble approach integrated multiple SDM algorithms to reduce uncertainty and improve predictive accuracy.

Controlled release mechanism of off-flavor compounds in Bacillus subtilis BSNK-5 fermented soymilk and flavor improvement by phenolic compounds.

Bacillus subtilis is the primary strain used in fermented soy products. The applicant fermented soymilk with the laboratory strain B. subtilis BSNK-5 to enhance nutrient density.

Distinct responses of Caenorhabditis elegans to polyethylene microplastics and plant secondary metabolites.

Soil worms are among the most abundant and functionally diverse soil animals. However, they have been largely overlooked in studies on microplastic (MP) toxicity. MPs and plant secondary metabolites (PSMs) are ubiquitous in soil due to plant litter decomposition and heavy MP contamination, inevitably interacting and exerting combined toxicity on soil organisms.

Study on the Mechanical and Thermal Properties of Waterborne Polyurethane-Modified Aluminum Hydroxide and Its Application in LDPE Plastics.

This study investigates the modification of aluminum hydroxide (ATH) powder using waterborne polyurethane (WPU) as a novel modifier, along with its subsequent effects on the dispersion, mechanical properties, and thermal performance of ATH-filled low-density polyethylene (LDPE) composites. ATH was modified through an optimized wet process, and the modification efficiency was evaluated using various characterization techniques, including scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). The results show that WPU, as a modifier, effectively improved the dispersion of ATH in the organic phase, as demonstrated by the reduced settling time and enhanced interfacial compatibility between ATH and LDPE.

Microplastic-Induced Alterations in Soil Aggregate-Associated Carbon Stabilization Pathways: Evidence from δC Signature Analysis.

Microplastics (MPs) are known to affect soil carbon stability in a numerous ways. However, the mechanisms by which they alter the carbon stability within soil aggregates remain unclear . Herein, a one-year field experiment was conducted in an arid agricultural region employing stable isotope techniques to evaluate the soil organic carbon flow in the presence of both persistent (PE, PVC) and biodegradable (PLA, PHA) MPs.

A multi-channel CRISPR-based method for rapid, sensitive detection of four diseases of in the field.

Pathogens significantly restrict the production of ( L. ssp. Pekinensis), with climate change and evolving planting patterns exacerbating disease prevalence.

Construction of CeO/TiCT heterojunction with antibacterial and antioxidant capabilities for diabetic wound healing.

Diabetic wounds are highly prone to persistent pathogenic infections due to the complex nature of their microenvironment, which significantly hinders the healing process under hyperglycemic conditions. In this study, we developed a bio-heterojunction enzyme system consisting of hollow CeO/TiCT MXene quantum dots (CeO@MQD) integrated with glucose oxidase (GOx-CeO@MQD). The GOx-CeO@MQD system exhibits multifunctional enzymatic activities, including peroxidase (POD) and catalase (CAT)-like activity, resulting in the production of •OH and O, alongside the consumption of glucose and glutathione (GSH).

Spatiotemporally resolved transcriptomics reveals the cellular dynamics of human retinal development.

The morphogenesis and cellular interactions in developing retina are incompletely characterized. The full understanding needs a precise mapping of the gene expression with a single-cell spatial resolution. Here, we present a spatial transcriptomic (ST) resource for the developing human retina at six developmental stages.

Suppressing the Bottom Small n Phases of Quasi-2D Perovskites for High-Performance Photovoltaic Applications.

The bottom small n phases in quasi-two-dimensional (Q-2D) perovskite films significantly hinder their photovoltaic performance development due to their severely low conductivity and nonideal band alignment in the corresponding solar cells. In this study, we successfully suppressed the growth of small n phases in Q-2D Ruddlesden-Popper (RP) perovskite (BAMAPbI, ⟨⟩ = 5) films by introducing 2,7-bis(diphenylphosphoryl)-9,9'-spirobifluorene (SPPO13) as an additive into the perovskite precursor solution. It is interesting to find that the hole transport layer poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] (PTAA) in our p-i-n device can attract the SPPO13 due to the π-π stacking effect.

[ Pills improves depression-like behavior in rats by regulating neurotransmitters, inhibiting inflammation and oxidation and modulating intestinal flora].

Objectives: To explore the bioactive components in Pills (JWXYP) and their mechanisms for alleviating depression-like behaviors.

Methods: The active compounds, key targets, and pathways of JWXYP were identified using TCMSP and TCMIP databases. Thirty-six SD rats were randomized equally into 6 groups including a control group and 5 chronic unpredictable mild stress (CUMS)-induced depression groups.

Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study.

Studies on the trajectories of lipid profile with cognitive decline are scarce and inconsistent. We examined this association and explored potential effect modification. Lipid profiles including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and total cholesterol (TC) were measured at baseline, first and second follow-ups, and classified into trajectory groups.

Pilot-scale partial nitrification and anaerobic ammonium oxidation system for nitrogen removal from municipal wastewater.

Partial nitrification has the advantages of saving energy and reducing the need for carbon sources in municipal wastewater treatment. However, for municipal wastewater with low ammonia, start-up and maintenance of partial nitrification is a worldwide challenge. Here we developed a pilot-scale double sludge system consisting of two sequencing batch reactors for partial nitrification (12 m) and denitrification/anaerobic ammonium oxidation (denitrification/anammox, 8.

Study of Construction of Innovative Barite/Waterborne Polyurethane/Low-Density Polyethylene Composites for Enhanced X-Ray Shielding Performance.

X-rays' high-energy nature poses risks to human health. Traditional X-ray shielding materials often contain toxic lead and have drawbacks like bulkiness and rigidity. Consequently, there is an increasing need to develop lightweight, non-toxic, flexible, and efficient shielding materials.

Digital Therapeutics-Based Cardio-Oncology Rehabilitation for Lung Cancer Survivors: Randomized Controlled Trial.

Background: Lung cancer ranks as the leading cause of cancer-related deaths. For lung cancer survivors, cardiopulmonary fitness is a strong independent predictor of survival, while surgical interventions impact both cardiovascular and pulmonary function. Home-based cardiac telerehabilitation through wearable devices and mobile apps is a substitution for traditional, center-based rehabilitation with equal efficacy and a higher completion rate.

Efficacy and safety of Janus kinase inhibitors in the treatment of psoriasis and psoriatic arthritis: An analysis of evidence from 2014 to 2022.

Background: The efficacy and safety of Janus kinase (JAK) inhibitors as novel therapeutic agents for psoriasis (PSO) and psoriatic arthritis (PsA) have not yet been systematically evaluated.

Methods: Randomized controlled studies (RCTs) assessing JAK inhibitors to treat PSO or PsA published before September 1, 2022, were searched in the PubMed, Embase, and Cochrane Library databases. The Psoriasis Area and Severity Index (PASI) 75 and American College of Rheumatology (ACR) 50 were established as primary outcome indicators of PSO and PsA, respectively.

ROS-Modulating Bio-Heterojunction Nanosheets for Infected Wound Healing via Nanozyme Activity.

Reactive oxygen species (ROS) play a pivotal role in wound healing due to their ability to eradicate bacterial infections. However, excessive ROS can induce oxidative stress and prolonged inflammation, which significantly hinder the wound-healing process. To address this challenge, TiCT-Se NPs (TS) heterojunction nanosheets, are developed which enhance electron transfer under near-infrared (NIR) laser irradiation confirmed by ultraviolet photoelectron spectroscopy (UPS) analysis.

Evidence-based dietary recommendations for patients with psoriasis: A systematic review.

Psoriasis is a chronic recurrent inflammatory skin disease mediated by immune, genetic, and environmental factors. Numerous studies have demonstrated that the excessive consumption of certain pro-inflammatory foods, including alcohol, dairy products, high-sugar foods, and gluten, can exacerbate psoriasis. Thus, modifying one's dietary habits can alleviate psoriasis symptoms.

High-temperature RGB ultralong afterglow carbon dots based on cavity encapsulated by cyclodextrins for anti-counterfeiting and information encryption.

Room temperature phosphorescent (RTP) carbon dots (CDs) have the disadvantages of short lifetime, single wavelength and poor stability. Phosphorescence usually suffers severe thermal decay due to strong non-radiative transitions caused by temperature increasing, limiting the use of CDs. Herein, α-Cyclodextrin provides hydrophobic cavities, so for CDs can be encapsulated into this cavity.

Transformation effects of Bacillus subtilis BSNK-5 on okara: Insights into its component transformation, structural characteristics, and functional properties.

The high-value utilization of okara is vital for promoting sustainable practices in the soybean industry and addressing global food security challenges. This study investigated the effects of Bacillus subtilis BSNK-5 fermentation on okara's nutritional, structural, and functional properties. BSNK-5 fermentation effectively degraded insoluble dietary fiber, protein, and fat into soluble fiber, peptides, amino acids, and fatty acids, while reducing trypsin inhibitors and antigenic proteins.

Multifunctional Carbon Quantum Dots for Monitoring and Therapy of Bacterial Infected Wounds.

Bacterial infections in wounds and bacteremia present significant global health challenges, driving the urgent need for innovative alternatives to traditional antibiotics. Here, the development of PEI-EDTA-2Na carbon quantum dots (PECDs) synthesized via a hydrothermal method is reported. Synthesis conditions affect PECDs' antibacterial efficacy; those at 180 °C have optimal -NH functionalization for better adhesion and activity.

Association of plasma fatty acid profile with trajectory of multimorbidity and mortality: A community-based longitudinal study.

Background: Plasma fatty acids have been linked to various chronic diseases and mortality, but the extent to which fatty acids are associated with the trajectory of multimorbidity remains unclear. We investigated the association of fatty acid profile with multimorbidity trajectories and event-free survival.

Methods: Within the UK Biobank, 138,685 chronic disease-free participants were followed for up to 16 years.

Multiomics analysis of O-GlcNAcylation in podocytes of diabetic kidney disease.

Aim: To investigate the role of O-GlcNAc transferase (OGT)-mediated protein O-GlcNAcylation in podocyte injury during the progression of diabetic kidney disease (DKD).

Materials And Methods: Proteomic and O-glycoproteomic analyses were conducted on high glucose (HG)-stimulated podocytes with OGT knockdown. Differentially expressed proteins and O-GlcNAcylated peptides/proteins were identified, and functional enrichment (GO, KEGG, COG/KOG) and motif analysis (motif-x) were performed using bioinformatics analysis.

Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation.

Background: Patients with microsatellite stable (MSS) colorectal cancer (CRC) often display resistance to immunotherapy. Epidermal growth factor receptor (EGFR)-targeted therapies have shown potential in enhancing immunotherapy, yet clinical benefits remain unfulfilled, which may relate to inadequate patient stratification.

Methods: Circulating tumor cells and tumor tissues were collected from multicenter cohorts of patients with CRC receiving cetuximab to analyze EGFR variant type III (EGFRvIII) expression and immune infiltration.