Biomaterial-based drug delivery strategies for oral mucosa.

Drug therapy is a key field in modern medicine, and the optimization of its delivery method is crucial. Traditional methods are inherently limited by first-pass effects, high-risk adverse reactions, and patient compliance challenges, which significantly restrict the effectiveness and application potential of drugs. Oral mucosal drug delivery has become a minimally invasive and effective drug delivery strategy.

Tumor-intrinsic PRMT5 upregulates FGL1 methylating TCF12 to inhibit CD8 T-cell-mediated antitumor immunity in liver cancer.

Protein arginine methyltransferase 5 (PRMT5) acts as an oncogene in liver cancer, yet its roles and in-depth molecular mechanisms within the liver cancer immune microenvironment remain mostly undefined. Here, we demonstrated that disruption of tumor-intrinsic PRMT5 enhances CD8 T-cell-mediated antitumor immunity both and . Further experiments verified that this effect is achieved through downregulation of the inhibitory immune checkpoint molecule, fibrinogen-like protein 1 (FGL1).

Quantitative Analysis of Contrast-Enhanced Ultrasound Images of Brain-Dead Donor Livers: Prediction of Early Allograft Dysfunction.

Objective: To determine the CEUS parameters that predict the likelihood of postoperative EAD.

Methods: Clinical and imaging data for 75 pairs of donors and recipients collected between September 2022 and July 2023 were retrospectively analyzed. Subjects were divided into those with early allograft dysfunction (EAD) and those without EAD.

Adhesive micro-liquid for efficient removal of bacterial biofilm infection.

Bacteria are common infectious pathogens that can cause invasive and potentially life-threatening infections. Ionic liquids have emerged as a novel class of alternatives to antibiotics, however their inherent hydrophobicity and immiscible in water exhibits poor adhesion to bacteria and diminishes its utilization and bioavailability for infection control. Herein, an adhesive metal phenolic encapsulated ionic liquid choline and geranate (CAGE@MPN) microcapsules is designed to address the aforementioned challenges and remove bacterial biofilm infections.

Sterol Regulatory Element-Binding Protein Sre1 Mediates the Development and Pathogenicity of the Grey Mould Fungus .

The grey mould fungus is a dangerous plant pathogen responsible for substantial agricultural losses worldwide. The pathogenic mechanisms still have many unclear aspects, and numerous new pathogenic genes remain to be identified. Here, we show that the sterol regulatory element-binding protein Sre1 plays an important role in the development and pathogenicity of .

In Situ Assembled Metal-Phenolic Nanozyme Biointerfaces Revitalize Stem Cells and Optimize Diabetic Implant Osseointegration.

The hyperglycemic microenvironment of diabetes inevitably leads to the accumulated reactive oxygen species (ROS) and impairs the function of stem cells, thereby impeding the process of osseointegration after implant placement. In this study, a self-assembled metal-phenolic nanozyme coating is presented for alleviating diabetic oxidative stress and improving osseointegration at implant interfaces. The antioxidant-like enzyme activity is induced by phenolic ligand-metal charge transfer (LMCT) during the coordination of epigallocatechin-3-gallate (EGCG) with copper phosphate nanosheets (Cu NS).

The effectiveness of dyadic interventions for health outcomes of prostate cancer patients and informal caregivers: a systematic review and meta-analysis.

Background: Prostate cancer is a worldwide health issue, and current prostate cancer care extends to the patient‒caregiver dyadic setting, where individuals are interdependent and interact with each other as well as possible negative psychological and behavioural outcomes. However, the impact of dyadic care interventions on health outcome indicators for prostate cancer patients and their informal caregivers has yet to be examined.

Aim: To describe the characteristics of dyadic interventions involving patients with prostate cancer and their informal caregivers and investigate their effects on psychosocial health, sexual health, and dyadic relationships.

The Experience of Adults' Family Caregivers Using Home Care Services: A Scoping Review.

Aim: To review the experiences of family caregivers using home care services, the perception of home care services and the positive and negative effects on family caregivers.

Design: A scoping review of the literature was undertaken using JBI guidance.

Data Sources: Databases were searched in November 2023, including PubMed, Web of Science, Embase, CINAHL, Cochrane Library and CNKI (China National Knowledge Infrastructure).

A mini-invasive injectable hydrogel for temporomandibular joint osteoarthritis: Its pleiotropic effects and multiple pathways in cartilage regeneration.

There are two bottlenecks in the treatment of TMJOA (temporomandibular joint osteoarthritis): ① lacking of easy-to-use repairing materials for damaged condylar cartilage; ② local inflammation interfering with in situ regeneration. In response to them, we constructed a biomimetic tilapia type I gelatin/hyaluronic acid (TGI/HA) hydrogel in this paper. It was endowed with the capability to immunoregulate mircoenvironment and concurrently induce regeneration in multiple ways.

How to Encourage the Public to Help People With Dementia in the Community: A Scoping Review.

Background: In a response to the lack of public awareness of dementia, 'ageing in place' and 'dementia-friendly community' policies have been proposed, and a number of relevant studies have been carried out.

Aim: To map the evidence of public help for people with dementia in the community.

Design: A scoping review.

Incidence and Associated Factors of Prehospital Care-Seeking Delay in People with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Background: Despite decades of educational efforts, patients with acute ischemic stroke (AIS) remain delayed in seeking medical care, which becomes the greatest obstacle to the successful management of the condition.

Objective: The objective of this study was to systematically explore the incidence and influencing factors of prehospital care-seeking delay in AIS patients.

Methods: We systematically searched the PubMed, Embase, Cochrane Library, Web of Science, and Cumulative Index to Nursing and Allied Health Literature from database inception to September 30, 2023.

Striking a balance: health behaviour changes in Chinese spouses of people with dementia to manage dementia risk: a qualitative study.

Background: Multiple studies have shown that spouses of people with dementia (PwD) are two to six times more likely to develop dementia compared to the general population. Encouraging healthy behaviours and addressing modifiable risk factors could potentially prevent or delay up to 40% of dementia cases. However, little is known about how health behaviours change when a spouse assumes the role of primary caregiver.

Effect of Aconitum diphtheria on the Proliferation, Apoptosis, and Inflammatory Response of Rheumatoid Arthritis Fibroblast-Like Synoviocytes.

Rheumatoid arthritis (RA), a highly disabling autoimmune disease, is characterized by joint damage and synovial hyperplasia. This paper was designed to explore the effect and mechanisms of Aconitum diphtheria on the proliferation and apoptosis of RA fibroblast-like synoviocytes (RA-FLS). First, RA-FLS was treated with different doses of A.

One-Step Hydrothermal Synthesis of Glucose-Induced Low Crystallinity NiCo-Based Layered Double Hydroxides for High-Performance Asymmetric Supercapacitors.

In order to improve the electrochemical performance of NiCo-based layered double hydroxide (NiCoLDH), the synthesis of low-crystallinity NiCoLDH was induced by the adsorption of glucose and NiCoLDH. The results showed that glucose could not only effectively regulate the pore structure and morphology of NiCoLDH, but also had a regular effect on crystallinity. Pure phase NiCoLDH had higher crystallinity.

Characteristics of relatives with high expressed emotion and related factors: a study of relatives of people with dementia in China.

Background: China has the highest number of people with dementia globally, and the responsibility of caring for people with dementia primarily falls on relatives, who bear heavy caregiving burdens and pressure. Providing care for an individual with dementia is emotionally and physically demanding, particularly due to the frequent manifestation of behavioral and psychological symptoms associated with dementia (BPSD). This underscores the crucial need to comprehend and address caregivers' emotional expression (EE).

Remineralization and bacterial inhibition of early enamel caries surfaces by carboxymethyl chitosan lysozyme nanogels loaded with antibacterial drugs.

Objective: This study aimed to develop dual-functional CMC-LYZ-ACP nanogels. Three different antibacterial substances, tea polyphenols (TPs), silver nitrate (AgNO), and chlorhexidine (CHX) are then combined to form three dual-functional CMC-LYZ-ACP nanogels for remineralization and antibacterial purposes.

Methods: An in vitro model of Streptococcus mutans biofilm was established to analyze the inhibitory effect of the antibacterial-remineralizing dual-functional nanogels on the biofilm.

Effects of a grouping intervention using the Felder-Silverman learning style model on problem-based learning among nursing students: A randomized controlled trial.

Background: Problem-Based Learning (PBL) education can improve nursing students' thinking skills and overall quality of life, but its effectiveness depends largely on the level of student engagement within the group. Finding an intervention to increase nursing students' classroom engagement is critical to improving learning outcomes.

Objectives: To explore the impact of a grouping intervention using the Felder-Silverman Learning Style Model (FSLSM) on PBL in nursing education, including classroom engagement, critical thinking, self-directed learning skills, and academic performance.

Sea Buckthorn Flavonoid Extracted with High Hydrostatic Pressure Alleviated Shrimp Allergy in Mice through the Microbiota and Metabolism.

Sea buckthorn ( L.) known as the deciduous shrub has been reported to have effects of antioxidant, anti-inflammatory, and immunomodulatory activities. Tropomyosin (TM) induced a regulatory immune response associated with food allergy.

A Review of the Biomimetic Structural Design of Sandwich Composite Materials.

Sandwich composites are widely used in engineering due to their excellent mechanical properties. Accordingly, the problem of interface bonding between their panels and core layers has always been a hot research topic. The emergence of biomimetic technology has enabled the integration of the structure and function of biological materials from living organisms or nature into the design of sandwich composites, greatly improving the interface bonding and overall performance of heterogeneous materials.

Preterm Birth in African American Women: A Multi-Omic Pilot Study in Early Pregnancy.

Preterm birth (PTB; <37 weeks completed gestation) is a devastating problem affecting over 13 million live births worldwide. In the U.S.

Parameter Optimization of a Surface Mechanical Rolling Treatment Process to Improve the Surface Integrity and Fatigue Property of FV520B Steel by Machine Learning.

Surface integrity is a critical factor that affects the fatigue resistance of materials. A surface mechanical rolling treatment (SMRT) process can effectively improve the surface integrity of the material, thus enhancing the fatigue property. In this paper, an analysis of variance (ANOVA) and signal-to-noise ratio (SNR) are performed by orthogonal experimental design with SMRT parameters as variables and surface integrity indicators as optimization objectives, and the support vector machine-active learning (SVM-AL) model is proposed based on machine learning theory.