Comprehensive Study of Electronic, Optical, and Thermophysical Properties of Metavanadates CaVO and MgVO.

Calcium metavanadate (CaVO) and magnesium metavanadate (MgVO) have received considerable attention due to their great potential for many practical applications; however, a fundamental understanding of their intrinsic physical properties is still not well established. Here, we present a comprehensive experimental and theoretical study of the optical, electronic, and lattice dynamic properties of CaVO and MgVO. We find that both compounds are semiconductors with indirect band gaps and exhibit visible light-emitting properties, which are thus expected to be the ideal candidates for phosphors or optoelectronic devices.

Effect of β-Blocker Therapy on the Level of Soluble ST2 Protein in Pediatric Dilated Cardiomyopathy.

Background and Objectives: A prognosis for kids with pediatric dilated cardiomyopathy (PDCM) is urgently needed to identify high-risk patients. This study aimed to determine the association of levels and soluble suppression of tumorigenicity 2 (sST2) and medical therapy of β-blocker inhibitors with the risk of adverse events in PDCM. Materials and Methods: A total of 124 patients with PDCM were enrolled after admission from 2 centers in China and followed up for adverse events (death, cardiac transplantation, and heart-failure-related rehospitalization).

Adolescent and Young Adult Perspectives on Quality and Value in Health Care.

Objective: To describe adolescent and young adult (AYA) perspectives on defining quality and value in health care and to gain understanding of their knowledge of value-based payment.

Methods: A text message-based survey was sent to a convenience sample of AYAs aged 14 to 24 in 2019. Participants were asked 4 open-ended questions: 1) how they would define "good health care," 2) what factors to consider in rating doctors, 3) whose opinions should matter most when rating doctors, and 4) the best ways to collect AYA opinions on doctors, and one yes/no question on their awareness of value-based payment.

Effects of AMF on plant nutrition and growth depend on substrate gravel content and patchiness in the karst species L.

Karst ecosystems represent a typical heterogeneous habitat, and it is ubiquitous with varying interactive patches of rock and soil associated with differential weathering patterns of carbonate rocks. Arbuscular mycorrhizae fungi (AMF) play an important role in regulating plant growth and nutrition in heterogeneous karst habitats. However, it remains unclear how AMF affects the growth and nutrition of plants in heterogeneous karst soil with varying patches and weathering gravel.

Clinical significance of SPOCK2 expression signature for high-grade serous ovarian cancer patients.

SPOCK2 is a member of the SPOCK family, a 424-amino acid protein that binds to glycosaminoglycans to form proteoglycans. The purpose of this study was to explore expression profile of SPOCK2, and evaluate prognostic potential and its correlation with immune infiltration in high-grade serous ovarian cancer (HGSOC). Expression of SPOCK2 mRNA and protein between normal and tumor tissues were analyzed using the Cancer Genome Atlas database (TCGA), Gene Expression Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and the Human Protein Atlas (HPA) databases.

Burden of Nutritional Deficiencies in China: Findings from the Global Burden of Disease Study 2019.

From 1990 to 2019, the age-standardized incidence rate of nutritional deficiencies in China remained stable. However, the age-standardized disability-adjusted life-years (DALY) rate of nutritional deficiencies decreased from 1990 to 2019. Data were extracted from the GBD 2019 datasets.

Spatio-Temporal Analysis and Influencing Factors of Rural Resilience from the Perspective of Sustainable Rural Development.

Rural resilience is not only a comprehensive reflection of "thriving businesses, pleasant living environments, social etiquette and civility, effective governance, and prosperity". It is also the unity of resilience in industry, ecology, culture, organization and livelihood. This paper uses the entropy weight-TOPSIS method to measure the rural resilience level in 31 regions in China and analyzes the configuration of influencing factors with the Fuzzy-set qualitative comparative analysis (fsQCA).

Coupling Coordination and Interactive Response Analysis of Ecological Environment and Urban Resilience in the Yangtze River Economic Belt.

There is a complex dynamic coupling interaction process between the ecological environment and urban resilience. It is important to clarify the coordination relationship and interactive response mechanism between them for sustainable development construction of the Yangtze River Economic Belt. The coupling coordination degree model and the panel vector autoregressive model (PVAR) were adopted to quantitatively examine the dynamic coordination and interactive response of the ecological environment and urban resilience in the Yangtze River Economic Belt from 2000 to 2019.

Elucidating tumor heterogeneity from spatially resolved transcriptomics data by multi-view graph collaborative learning.

Spatially resolved transcriptomics (SRT) technology enables us to gain novel insights into tissue architecture and cell development, especially in tumors. However, lacking computational exploitation of biological contexts and multi-view features severely hinders the elucidation of tissue heterogeneity. Here, we propose stMVC, a multi-view graph collaborative-learning model that integrates histology, gene expression, spatial location, and biological contexts in analyzing SRT data by attention.

Analysis of the therapeutic effect of transanal endoscopic microsurgery on large rectal adenoma.

Purpose: Rectal adenoma, a pre-cancerous lesion, is one of the indications for transanal endoscopic microsurgery (TEM). TEM has its unique advantages in the treatment of rectal adenomas. However, there are few reports on the therapeutic effects of large rectal adenoma (LRA).

Brain-targeted CRISPR/Cas9 nanomedicine for effective glioblastoma therapy.

CRISPR/Cas9 gene-editing technology shows great potential for treating a variety of diseases, such as glioblastoma multiforme (GBM). However, CRISPR components suffer from inherent delivery challenges, such as poor in vivo stability of Cas9 protein and gRNA, low blood-brain barrier (BBB) permeability and non-specific tissue or cell targeting. These defects have limited the application of Cas9/gRNA ribonucleoprotein (RNP) complexes for GBM therapy.

Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance.

Phenylacetic acid (PAA) is a central intermediate metabolite involved in bacterial degradation of aromatic components. The bacterial PAA pathway mainly contains 12 enzymes and a transcriptional regulator, which are involved in biofilm formation and antimicrobial activity. They are present in approximately 16% of the sequenced bacterial genome.

Associations between Dynamic Vitamin D Level and Thyroid Function during Pregnancy.

Optimal Vitamin D (VitD) status and thyroid function are essential for pregnant women. This study aimed to explore associations between dynamic VitD status and thyroid function parameters in each trimester and throughout the pregnancy period. Information on all 8828 eligible participants was extracted from the Peking University Retrospective Birth Cohort in Tongzhou.

Metagenomic next-generation sequencing provides prognostic warning by identifying mixed infections in nocardiosis.

is an opportunistic pathogen that mainly involves immunosuppressed patients and causes a high mortality rate. As an emerging approach to detect infectious pathogens, metagenomic next-generation sequencing (mNGS) was reported in the detection of . However, there is no evidence demonstrating the effect of mNGS on the prognosis of infection.

Factors that dynamically affect provincial incidences of catastrophic health expenditure among middle-aged and elderly Chinese population-transition of disease financial risk protection from global to local.

Background: The high incidence of catastrophic health expenditure (ICHE) among middle-aged and elderly population is a major deterrent for reducing the financial risk of disease. Current research is predominantly based on the assumption of spatial homogeneity of nationwide population characteristics, ignoring the differences in regional characteristics. Thus, our study aimed to explore the impact of various influencing factors on the ICHE from a spatiotemporal perspective.

EEG Source Imaging using GANs with Deep Image Prior.

Brain source localization from electroencephalogram (EEG) signals is an challenging problem for noninvasively localizing the brain activity. Conventional methods use handcrafted regularization terms based on neural-physiological assumptions by exploiting the spatial-temporal structure on the source signals. In recent years, deep learning frameworks have demonstrated superior performance for solving the inverse problems in the natural and medical imaging field.

Riverine microplastics derived from mulch film in Hainan Island: Occurrence, source and fate.

Mulch film (MF) residues is an important source of microplastics (MPs) in farmland, but its transportation risk to the wider environment was still unknown. Some researches have pursued the sources of MPs found in exorheic rivers. Even so, a systematic study depicting the occurrence, source and fate of microplastics derived from mulch films (MPMF), the crucial component of MPs in farmlands, in exorheic rivers still lacking.

Identifying potential ligands specifically binding to beta1-adrenoceptor from Radix Aconiti Lateralis Praeparata extract by affinity chromatographic method.

As expressed predominantly in cardiac tissue, beta1-adrenoceptor (β-AR) is broadly accepted as one of the main targets for drugs against cardiovascular ailments. However, the discovery of β-AR ligand is gravely challenged due to the lack of efficient screening method. This work developed a general strategy for pursuing β-AR ligands from the herbal extract by immobilizing haloalkane dehalogenase (Halo)-tagged β-AR onto microspheres coated with 6-chlorohexanoic acid, and applying the immobilized β-AR in the analysis of ligand-receptor interaction.

Eosinophil as a biomarker for diagnosis, prediction, and prognosis evaluation of severe checkpoint inhibitor pneumonitis.

Introduction: Checkpoint inhibitor pneumonitis (CIP) is a common serious adverse event caused by immune checkpoint inhibitors (ICIs), and severe CIP can be life-threatening. We aimed to investigate the role of peripheral blood cells in diagnosis, prediction, and prognosis evaluation for all and severe CIP.

Materials And Methods: Patients with lung cancer receiving ICIs were enrolled in this retrospective study.

Study of the Steady-State Operation of a Dual-Longitudinal-Mode and Self-Biasing Laser Gyroscope.

In order to stabilize the self-biasing state of a laser gyroscope, a dual-longitudinal-mode asymmetric frequency stabilization technique was studied. The special frequency stabilization is based on the accurate control of the intensity tuning curve in the prism ring laser. In this study, the effects of the ratio of the Ne isotopes, the inflation pressure, and the frequencies coupling on the intensity tuning curve in a laser gyro were examined.

Link Prediction in Complex Networks Using Recursive Feature Elimination and Stacking Ensemble Learning.

Link prediction is an important task in the field of network analysis and modeling, and predicts missing links in current networks and new links in future networks. In order to improve the performance of link prediction, we integrate global, local, and quasi-local topological information of networks. Here, a novel stacking ensemble framework is proposed for link prediction in this paper.

Distribution and retention of microplastics in plantation mangrove forest sediments.

Microplastics (MPs) in ocean tides can be effectively intercepted by mangroves, especially sediments, which are considered to be effective sinks. However, the retention of plantation mangrove forests on MPs is still unclear. In this study, the spatial distribution and its implication factors of MPs in surface sediments of plantation mangrove forests were investigated for the first time.

Transcriptional patterns reveal tumor histologic heterogeneity and immunotherapy response in lung adenocarcinoma.

Tumoral heterogeneity has proven to be a leading cause of difference in prognosis and acquired drug resistance. High intratumor heterogeneity often means poor clinical response and prognosis. Histopathological subtypes suggest tumor heterogeneity evolved during the progression of lung adenocarcinoma, but the exploration of its molecular mechanisms remains limited.

Animal Models of Rotator Cuff Injury and Repair: A Systematic Review.

There are a large number of animal studies on rotator cuff injury and repair, but a lack of detailed research and evaluation on the animal models. This systematic review aims to provide a framework for animal studies and repair patches for rotator cuff injury. Four hundred nine animal studies were included, of which the most common animal model of rotator cuff injury is rat (53.