Neuroinflammation is involved in the development of depression and may induce depression-like behaviors by affecting metabolism through interactions with circadian rhythms. As the hub of metabolism, mitochondria are regulated by various types of metabolism and release signals that regulate cellular functions. In this study, we performed transcriptomic analysis of the hippocampus of IL-33-overexpressing mice to provide new ideas to explore the pathogenesis of inflammation-mediated depression at the transcriptional level.
View Article and Find Full Text PDFDirect recycling of cathode materials has attracted phenomenal attention due to its economic and eco-friendly advantages. However, existing direct recycling technologies are difficult to apply to highly degraded layered materials as the accumulation of thick rock-salt phases on their surfaces not only blocks lithiation channels but also is thermodynamically difficult to transform into layered phases. Here, a surface engineering-assisted direct upcycling strategy that reactivates the lithium diffusion channels at the highly degraded cathode surfaces using acid etching explored.
View Article and Find Full Text PDFChilled meat is highly prone to microbial spoilage, and edible films with antimicrobial properties offer a feasible solution. In this study, oil-in-water (O/W) nanoemulsions loaded with lemon essential oil (LEO) were developed. Nanoemulsification improved the antioxidant and antimicrobial activities of LEO.
View Article and Find Full Text PDFPeritoneal carcinomatosis (PC) is a common metastatic cancer with limited treatment options. Herein, we present a novel strategy for the combined treatment of PC involving plasma-activated saline (PAS) and hyperthermic intraperitoneal perfusion. PAS revealed a strong cytotoxic effect because of reactive oxygen species (ROS) in two-dimensional cultures and three-dimensional tumor spheroids of PC-related cell lines.
View Article and Find Full Text PDFInsect pests strongly affect crop growth and value globally. Fast and precise pest detection and counting are crucial measures in the management and mitigation of pest infestations. In this area, deep learning technologies have come to represent the method with the most potential.
View Article and Find Full Text PDFObjectives: The aims of this study were to investigate whether CSF sTREM2 may be a potential marker of disease monitoring for amyotrophic lateral sclerosis (ALS).
Methods: We investigated whether CSF sTREM2 levels are altered in ALS patients and are correlated with upper motor neuron (UMN) burden and disease progression.
Results: CSF sTREM2 was greater in the ALS patients than in the controls ( = 0.
Purpose: This study was designed to evaluate the effect and mechanism of the Qushi Huatan (QSHT) decoction against coronary heart disease (CHD) through network pharmacology and experimental verification.
Methods: In the present study, the active ingredients of the QSHT decoction were identified by ultra performance liquid chromatography/tandem mass spectrometry (UPLC/MS), then the potential ingredients and coronary heart disease targets were predicted using the SwissTarget Prediction database and the database of Genecards and OMIM database, respectively. A herb-compound-target network was constructed using Cytoscape.
The burgeoning accumulation of spent lithium-ion batteries (LIBs), a byproduct from the widespread adoption of portable electronics and electric vehicles, necessitates efficient recycling strategies. Direct recycling represents a promising strategy to maximize the value of LIB waste and minimize harmful environmental outcomes. However, current efforts to large-scale direct recycling face challenges stemming from heterophase residues (e.
View Article and Find Full Text PDFBackground: Treatment with different antipsychotics can lead to various metabolic side effects in patients with psychosis, impacting long-term prognosis. This study aimed to compare the changes and clinical efficacy of insulin resistance in patients treated with olanzapine and ziprasidone.
Method: A retrospective analysis was conducted on the clinical data of 80 patients with schizophrenia.
Malignant melanoma is the most lethal form of skin cancer. As a promising anti-cancer agent, plasma-activated water (PAW) rich in reactive oxygen and nitrogen species (RONS) has shown significant potential for melanoma treatment. However, rapid decay of RONS and inefficient delivery of PAW in conventional injection methods limit its practical applications.
View Article and Find Full Text PDFThe extracellular matrix (ECM) shapes the stem cell fate during differentiation by exerting relevant biophysical cues. However, the mechanism of stem cell fate decisions in response to ECM-backed complex biophysical cues has not been fully understood due to the lack of versatile ECMs. Here, we designed two versatile ECMs using colloidal self-assembly technology to probe the mechanisms of their effects on mechanotransduction and stem cell fate regulation.
View Article and Find Full Text PDFBackground And Aim: There is a pressing need for non-invasive preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma (HCC). This study investigates the potential of exosome-derived mRNA in plasma as a biomarker for diagnosing MVI.
Methods: Patients with suspected HCC undergoing hepatectomy were prospectively recruited for preoperative peripheral blood collection.
Ethnopharmacological Relevance: In recent years, in addition to hypertension, hyperglycemia, and hyperlipidemia, the prevalence of hyperuricemia (HUA) has increased considerably. Being the fourth major health risk factor, HUA can affect the kidneys and cardiovascular system. Chrysanthemi Indici Flos is a flavonoid-containing traditional Chinese patent medicine that exhibits a uric acid (UA)-lowering effect.
View Article and Find Full Text PDFThe paper introduces 's clinical experience in treatment of knee osteoarthritis (KOA) by manual mobilization of meridian muscle regions. Professor believes that the key to the occurrence and development of KOA lies in the disorder of meridian muscle regions (sinews/fascia). In pathology, four stages are divided, i.
View Article and Find Full Text PDFObjectives: Prostate cancer (PRAD) is a highly malignant disease with poor prognosis, and its development is regulated by a complex network of genes and signaling pathways. LncRNAs and miRNAs have significant regulatory roles in PRAD through the ceRNA network. Cuproptosis is a unique form of programmed cell death that is involved in various signaling pathways and biological processes related to tumor development.
View Article and Find Full Text PDFAn intermolecular controllable Pd-catalyzed spirocyclization of isocyano cycloalkenes has been developed, offering efficient and selective approaches toward spirocyclic hydropyrrole scaffolds. 2-Azaspiro-1,7-dienes could be obtained through a "chain-walking" process with aryl/vinyl iodides as electrophiles, while the normal Heck product 2-azaspiro-1,6-dienes were selectively generated when aryl triflates were used as the coupling partner of isocyanides. Mechanistic studies suggested that the counteranion of the Pd(II) intermediate played a crucial role in the regioselectivity control.
View Article and Find Full Text PDFAm J Physiol Endocrinol Metab
April 2024
Vitamin D (VD) is a fat-soluble sterol that possesses a wide range of physiological functions. The present study aimed to evaluate the effects of VD on folate metabolism in zebrafish and further investigated the underlying mechanism. Wild-type (WT) zebrafish were fed with a diet containing 0 IU/kg VD or 800 IU/kg VD for 3 wk.
View Article and Find Full Text PDFMath Biosci Eng
October 2023
In this paper, we successfully combine convolution with a wave function to build an effective and efficient classifier for traffic signs, named the wave interference network (WiNet). In the WiNet, the feature map extracted by the convolutional filters is refined into many entities from an input image. Each entity is represented as a wave.
View Article and Find Full Text PDFVitamin D (VD) is a steroid hormone that is widely known to play an important role in maintaining mineral homeostasis, and regulating various physiological functions. Our previous results demonstrated that the interruption of VD metabolism caused hyperglycemia in zebrafish. In the present study we further explored the mechanism that VD regulates glucose metabolism by maintaining intestinal homeostasis in zebrafish.
View Article and Find Full Text PDFObjective: To explore the manifestations of (sinews/fascia) lesions and summarize their distribution rules in the patients with neck-type cervical spondylosis so as to provide the evidences for the development of clinical diagnosis and treatment scheme of acupuncture for cervical spondylosis.
Methods: A total of 120 patients with neck-type cervical spondylosis were collected. The meridian diagnostic method was used to examine the upper back of each patient, the manifestation category of lesions, locations and the affected muscle regions of twelve meridians were recorded.