Open surgical treatment for giant presacral tailgut cyst - a case report.

Tailgut cyst is an exceedingly rare congenital anomaly originating from embryonic remnants of the tailgut. Owing to its asymptomatic nature in the early stages, it is prone to clinical misdiagnosis. We present a case of a 55-year-old female with initial symptoms manifesting as sacrococcygeal pain.

A Novel Endophytic Fungus R-423 for the Control of Root Rot in Pigeon Pea as Reflected by the Alleviation of Reactive Oxygen Species-Mediated Host Defense Responses.

root rot is a devastating fungal disease that causes significant yield losses in legume crops. A novel endophytic fungus R-423 isolated from pigeon pea had a significant antagonistic capacity against . R-423 extracts could inhibit growth and cause it to die.

The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity.

Ubiquitin-conjugating enzymes (E2s) are key for protein turnover and quality control via ubiquitination. Some E2s also physically interact with the proteasome, but it remains undetermined which E2s maintain proteostasis during aging. Here, we find that E2s have diverse roles in handling a model aggregation-prone protein (huntingtin-polyQ) in the Drosophila retina: while some E2s mediate aggregate assembly, UBE2D/effete (eff) and other E2s are required for huntingtin-polyQ degradation.

Precise Measurement of the e^{+}e^{-}→D_{s}^{+}D_{s}^{-} Cross Section at Center-of-Mass Energies from Threshold to 4.95 GeV.

Using the e^{+}e^{-} collision data collected with the BESIII detector operating at the BEPCII collider, at center-of-mass energies from the threshold to 4.95 GeV, we present precise measurements of the cross section for the process e^{+}e^{-}→D_{s}^{+}D_{s}^{-} using a single-tag method. The resulting cross section line shape exhibits several new structures, thereby offering an input for a future coupled-channel analysis and model tests, which are critical to understand vector charmonium-like states with masses between 4 and 5 GeV.

Reductive acetogenesis is a dominant process in the ruminant hindgut.

Background: The microbes residing in ruminant gastrointestinal tracts play a crucial role in converting plant biomass to volatile fatty acids, which serve as the primary energy source for ruminants. This gastrointestinal tract comprises a foregut (rumen) and hindgut (cecum and colon), which differ in structures and functions, particularly with respect to feed digestion and fermentation. While the rumen microbiome has been extensively studied, the cecal microbiome remains much less investigated and understood, especially concerning the assembling microbial communities and overriding pathways of hydrogen metabolism.

The secrets to high-level green technology innovation of China's waste power battery recycling enterprises.

Green technology innovation (GTI) in China's waste power battery recycling (WPBR) sector is a key driver for sustainable resource management, environmental protection, and economic prosperity. Using the PSR-BN-GPT-4 model and multi-source data, this study explores China's WPBRenterprises' high-level GTI mechanism. The research concludes that (1) Compared to traditional expert knowledge, the Bayesian network model based on GPT-4 exhibits superior causal reasoning capability.

Fecal propionate is a signature of insulin resistance in polycystic ovary syndrome.

Objective: To investigate the roles of fecal short-chain fatty acids (SCFAs) in polycystic ovary syndrome (PCOS).

Methods: The levels of SCFAs (acetate, propionate, and butyrate) in 83 patients with PCOS and 63 controls were measured, and their relationships with various metabolic parameters were analyzed. Intestinal microbiome analysis was conducted to identify relevant bacteria.

PbOI: A Lead Oxyhalide IR Optical Crystal with an Unprecedented [OPb] Chain Featuring a Wide Transmittance Range and Large Birefringence.

Among the infrared (IR) optical material systems, the heavy-metal oxyhalide system has become an emerging system in recent years. Introducing heavy-metal cations and halogen anions with large atomic numbers is conducive to widening the IR transparency window and improving the birefringence value. Our experiments focus on the PbO-PbI system and find a new lead oxyhalide, PbOI.

Clone-Resolved Chemical Depletion of T cells via Cellular Proximity Chemistry.

T cells play a pivotal role in the development of autoimmune diseases. To mitigate autoimmune inflammation without inducing global immunosuppression, it is crucial to selectively eliminate autoreactive T cell clones while preserving the normal T cell repertoire. In this study, we applied cellular proximity chemistry to develop a T-cell depletion method with clonal precision.

Anti-osteosarcoma activity of Corynoline via Src/JNK signaling-mediated cell cycle arrest and mitochondrial apoptosis.

Corynoline (COR) is an isoquinoline alkaloid derived from the traditional Chinese medicine Corydalis bungeana Turcz, known for its analgesic, antibacterial, neuroprotective, and osteoporosis-alleviating properties. However, its potential molecular effects against osteosarcoma (OS) remain unclear, warranting further investigation. This study demonstrated that COR inhibits OS cell proliferation and promotes apoptosis in a dose-dependent manner.

An Airborne Gravity Gradient Compensation Method Based on Convolutional and Long Short-Term Memory Neural Networks.

As gravity exploration technology advances, gravity gradient measurement is becoming an increasingly important method for gravity detection. Airborne gravity gradient measurement is widely used in fields such as resource exploration, mineral detection, and oil and gas exploration. However, the motion and attitude changes of the aircraft can significantly affect the measurement results.

[Clinical efficacy of clear aligner treatment for pathologically migrated teeth in the anterior region of patients with severe periodontitis].

Objective: To evaluate the clinical efficacy of clear aligner therapy in patients with severe periodontitis accompanied by pathological tooth displacement in the anterior region.

Methods: This retrospective study analyzed patients diagnosed with severe periodontitis and pathological displacement in the anterior region, who visited both the Periodontics and Orthodontics Departments at Peking University School and Hospital of Stomatology between 2019 and 2022. A total of 26 eligible cases were included in this study.

Preparation and texture assessment of purple red rice bran anthocyanins-rice starch based dysphagia food masses.

The decline in physiological functions caused by aging increases the prevalence of dysphagia. Anthocyanins play a dual role in enhancing the nutrition of the food and influencing its swallowing properties. The objective of this study was to investigate the impact of anthocyanins from purple red rice bran on the viscosity, rheological and textural properties, and IDDSI classification of rice starch-based dysphagia food masses.

Ultrathin 2D Cu-Porphyrin MOF Nanosheet Loaded FeO Nanoparticles As a Multifunctional Nanoplatform for Synergetic Chemodynamic and Photodynamic Therapy Independent of O.

In this study, we developed a multifunctional nanoplatform to address the limitations of strictly acidic pH for the Fenton reaction involving FeO and the low efficiency of mono treatments. The hybrid material, FeO@Cu-TCPP, was assembled through hydrophobic interactions of polyvinylpyrrolidone (PVP) coated on its surface. The efficiency of the Fenton reaction using FeO was significantly enhanced by the photo-Fenton process in the presence of Cu-TCPP.

Early Motor Signs in Pathologically Verified Alzheimer's Disease and Lewy Body Disease.

Background: The neuropathologies of Alzheimer's disease (AD) and Lewy body disease (LBD) commonly co-occur. Parkinsonism is the hallmark feature in LBD but it can be difficult to predict the presence of these co-pathologies early in the course of clinical disease. Timely diagnosis has crucial implications, especially with the advent of disease-modifying therapies.

MD-Unet for tobacco leaf disease spot segmentation based on multi-scale residual dilated convolutions.

Identification and diagnosis of tobacco diseases are prerequisites for the scientific prevention and control of these ailments. To address the limitations of traditional methods, such as weak generalization and sensitivity to noise in segmenting tobacco leaf lesions, this study focused on four tobacco diseases: angular leaf spot, brown spot, wildfire disease, and frog eye disease. Building upon the Unet architecture, we developed the Multi-scale Residual Dilated Segmentation Model (MD-Unet) by enhancing the feature extraction module and integrating attention mechanisms.

Single-cell transcriptomics reveals the heterogeneity and function of mast cells in human ccRCC.

Introduction: The role of mast cells (MCs) in clear cell renal carcinoma (ccRCC) is unclear, and comprehensive single-cell studies of ccRCC MCs have not yet been performed.

Methods: To investigate the heterogeneity and effects of MCs in ccRCC, we studied single-cell transcriptomes from four ccRCC patients, integrating both single-cell sequencing and bulk tissue sequencing data from online sequencing databases, followed by validation via spatial transcriptomics and multiplex immunohistochemistry (mIHC).

Results: We identified four MC signature genes (TPSB2, TPSAB1, CPA3, and HPGDS).

Sun-simulated-driven production of high-purity methanol from carbon dioxide.

CO conversion to CHOH under mild conditions is of particular interest yet rather challenging. Both electro- and thermo-catalytic CO reduction to CHOH can only produce CHOH in low concentration (typically mixed with water), requiring energy-intensive purification processes. Here we design a sun-simulated-driven tandem catalytic system comprising CO electroreduction to syngas, and further photothermal conversion into high-purity CHOH (volume fraction > 97%).

Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls.

Background: Fibromyalgia is a chronic condition marked by widespread pain and various accompanying symptoms. Compared to healthy individuals and other rheumatic disease patients, it leads to more severe symptoms and a lower quality of life. Whether fibromyalgia patients in a mild activity or remission stage still experience core symptoms remains unclear.

Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients.

Recently, oncolytic virus (OV) therapy has shown great promise in treating malignancies. However, intravenous safety and inherent lack of immunity are two significant limitations in clinical practice. Herein, we successfully developed a recombinant Newcastle disease virus with porcine α1,3GT gene (NDV-GT) triggering hyperacute rejection.

A Dual-Mode Colorimetric and Fluorescence Biosensor Based on a Nucleic Acid Multiplexing Platform for the Detection of .

() is one of the most prevalent threats, capable of inducing diverse illnesses and presenting a serious threat to public health. Herein, we demonstrate a novel dual-mode colorimetric/fluorescence biosensor based on the xponential mplification reaction and trand isplacement eactions (EASDR), which has multiplexing capability that significantly promotes the anchoring and trapping of Pt nanoparticles (Pt NPs) and fluorescent dyes for sensitive detection of (). The method works by targeting specific bacteria with aptamers and promoting repeated EASDR to affect the immobilization of Pt NPs and fluorescent dyes in the orifice plate, which could produce changes in fluorescence and colorimetric signals.

Unraveling the ROS-Inflammation-Immune Balance: A New Perspective on Aging and Disease.

Increased entropy is a common cause of disease and aging. Lifespan entropy is the overall increase in disorder caused by a person over their lifetime. Aging leads to the excessive production of reactive oxygen species (ROS), which damage the antioxidant system and disrupt redox balance.

Pressure Sensor Array Based on Four DNA-Nanoenzymes with Catalase-like Activity for Portable Multiple Detection of Foodborne Pathogens.

This study has developed a pressure sensor array based on four functionalized DNA-nanoenzymes with catalase-like activity for multiple detections of foodborne pathogens through a portable pressure manometer. Benefiting from functionalization of 4-mercaptophenylboronic acid and β-mercaptoethylamine, the diversity of nonspecific interactions between four DNA-nanoenzymes and each of the nine bacteria leads to differences in pressure response patterns by catalyzing HO to generate exclusive "fingerprints". As effective statistical tools for processing multivariate data, principal component analysis and hierarchical clustering analysis are employed to identify nine foodborne pathogens by analyzing pressure response patterns.

Temperature-dependent pathways in carbon dioxide electroreduction.

Temperature affects both the thermodynamics of intermediate adsorption and the kinetics of elementary reactions. Despite its extensive study in thermocatalysis, temperature effect is typically overlooked in electrocatalysis. This study investigates how electrolyte temperature influences CO electroreduction over Cu catalysts.