Purpose: To investigate differences in left ventricular wall thickness (LVWT) measurements between end-diastole and mid-diastole using cardiac computed tomography (CCT) and establish LVWT reference values stratified by phase, sex, and region.
Methods: Subjects who underwent CCT without a history of cardiovascular disease or risk factors were retrospectively included between 2021 and 2024. LVWT was manually measured in each segment according to the American Heart Association's 17-segment model at end-diastole and mid-diastole.
Context: This study employs molecular dynamics simulations to investigate the nanoscale tribological behavior of a single transverse grain boundary in a nickel-based polycrystalline alloy. A series of simulations were conducted using a repetitive rotational friction method to explore the mechanisms by which different grain boundary positions influence variations in wear depth, friction force, friction coefficient, dislocation, stress, and internal damage during repeated friction processes. The results reveal that the grain boundary structure enhances the strength of the nanoscale nickel-based polycrystalline alloy.
View Article and Find Full Text PDFBackground: Primary hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by immune dysregulation. Hematopoietic stem cell transplantation (HSCT) represents the only option for long-term cure for primary HLH. However, only around 25% of patients have a fully HLA-matched donor.
View Article and Find Full Text PDFNon-host resistance (NHR) governs defense responses against a broad range of potential pathogen species in contrast with host resistance. To identify specific genes involved in disease resistance, we used a virus-induced gene-silencing screen in Nicotiana benthamiana and identified glycosyltransferase (NbGT) as an essential component of NHR. NbGT silencing enhanced the hypersensitivity response, reactive oxygen species response, and callose deposition in N.
View Article and Find Full Text PDFQuant Imaging Med Surg
December 2024
Background: Small fetuses include constitutional small for gestational age (SGA) and fetal growth-restricted (FGR) fetuses. Various adverse intrauterine environments can lead to FGR which has higher risk of abnormal perinatal outcome. The fetal heart is very sensitive to the effects of a negative intrauterine environment.
View Article and Find Full Text PDFPhenylalanine (Phe) is a potentially limiting amino acid for lactating cows. The mechanism by which Phe regulates milk protein synthesis remains unclear. The present study elucidates the mechanisms by which phenylalanine affects milk protein synthesis, amino acid utilization, and related signaling pathways in bovine mammary epithelial cells (BMECs).
View Article and Find Full Text PDFBackground: Several surgical techniques have been reported of subtalar instability (STI), but it remains a controversial topic without long-term clinical evidence. This study aimed to report the all-inside arthroscopic anatomic interosseous talocalcaneal ligament (ITCL) reconstruction technique and its long-term outcomes in STI patients with confirmed ITCL rupture.
Methods: A retrospective study was conducted on consecutive series of STI patients who underwent all-inside arthroscopic anatomic reconstruction of the ITCL using a gracilis autograft between January 2010 and December 2016.
Aldehydes have been proposed as important precursor species in new particle formation (NPF). Although formaldehyde (CHO) has minimal direct involvement in sulfuric acid (HSO) and water nucleation, it remains unclear whether its atmospheric aldol condensation product, hydroxyacetaldehyde (CHO), one of the simplest bifunctional oxygenated volatile organic compounds (OVOCs), plays a role in NPF. This study investigates both the aldol condensation of CHO and its role in NPF involving HSO and CHO through quantum chemical calculations and atmospheric cluster dynamics modeling.
View Article and Find Full Text PDFAccurate quantification of cisplatin (cDDP) in body fluids (blood, urine, and ascites) is crucial in monitoring therapeutic processes, assessing drug metabolism, and optimizing treatment schedules for cancer patients. Nonetheless, due to the inherent fluorescence and complexity of the body fluid matrix, along with the low cDDP concentrations in these fluids during treatment, using fluorescent sensors for fluid detection remains a subject of ongoing research. Herein, a series of water-soluble cDDP-activatable fluorescent sensors was rationally constructed by introducing thioether groups to the xanthene skeleton based on the chalcogenophilicity of platinum.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
March 2025
It is a highly desirable and formidable challenge to synthesize carbon dots with long-wavelength emission using green synthesis. In this work, we explored red-emitting carbon dots (rCDs) via a hydrothermal strategy and their multifunctional application for bioimaging in vivo/vitro, curcumin sensing, and antibacterial materials. As-prepared rCDs were water-soluble and monodispersed with an average diameter of 2.
View Article and Find Full Text PDFCurrent biomarkers for sepsis-associated acute kidney injury (SA-AKI) lack specificity. The role of soluble urokinase plasminogen activator receptor (suPAR) in discriminating AKI and SA-AKI in children remains elusive. This prospective multicenter study was conducted in critically ill children cohorts using a derivation-validation design, and plasma samples were collected within first 24 h after admission.
View Article and Find Full Text PDFTumor metabolism is crucial in the continuous advancement and complex growth of cancer. The emerging field of nanotechnology has made significant strides in enhancing the understanding of the complex metabolic intricacies inherent to tumors, offering potential avenues for their strategic manipulation to achieve therapeutic goals. This comprehensive review delves into the interplay between tumor metabolism and various facets of cancer, encompassing its origins, progression, and the formidable challenges posed by metastasis.
View Article and Find Full Text PDFThis study provides a practical route to synthesize tetrasubstituted alkenes that involves Co(III)-catalyzed C-H bond activation and regioselective insertion of the alkyne, followed by chelation of the substrate hydroxyl to Co and migration of the pyridine group. Density functional theory studies revealed the origin of regioselectivity and elucidated the crucial role of the hydroxyl group for the migration of pyridine. The method can be conducted on a gram scale, is compatible with a wide range of substrates, and has a high functional group tolerance.
View Article and Find Full Text PDFDietary factors play a crucial role in irritable bowel syndrome (IBS) pathogenesis. Therefore, the dietary contraindications for patients with IBS require further supplementation. Recent investigations have revealed that ginger consumption may pose a risk of aggravating the symptoms and incidence of IBS; however, the specific mechanism remains unknown.
View Article and Find Full Text PDFRecent studies have increasingly focused on PIK3CA mutations in esophageal squamous cell carcinoma (ESCC); however, the clinicopathological significance of these mutations within the tumor microenvironment remains underexplored. This study aimed to evaluate and compare the clinicopathological significance of mutated PIK3CA in ESCC using in silico analyses of the ESCC dataset from the TCGA database. We assessed prognosis, differential expression, correlation with immune cell infiltration and immune checkpoint expression, heterogeneity, and drug sensitivity in comparison with wild-type PIK3CA.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
xRNAs have received a lot of attention for their potential in targeted therapy. This study aims to construct nanoparticles using bovine serum albumin (BSA) and Camptothecin to improve the bioavailability and targeting of drugs through RNA packaging, thereby improving the prognosis of cancer patients. The phacoemulsification method was used to synthesize BSA-CPT-NPs, and the single factor orthogonal design method was used to optimize the process.
View Article and Find Full Text PDFObjective: To investigate the influencing factors of dysphagia in Alzheimer's disease (AD) patients.
Methods: The study evaluated the demographic characteristics, nutritional status, social functioning, and swallowing dysfunction of 109 hospitalized AD patients.
Results: The sample include 65.
Prep Biochem Biotechnol
October 2024
This study investigated the ultrasound-assisted extraction (UAE) techniques used to enhance the polyphenols and antioxidants of mango peel extract (MPE). Additionally, it explored the bacteriostatic activity of MPE against various microorganisms. The UAE method was optimized using response surface methodology (RSM) at different times, temperatures, and ratios, with optimal conditions found to be 35 minutes, 45 °C, and a 1:35 ratio.
View Article and Find Full Text PDFBackground: Ischemia-reperfusion injury (IRI) is a common pathophysiological mechanism of acute kidney injury (AKI). There is an urgent need for a more comprehensive analysis of its underlying mechanisms.
Materials And Methods: The RNA-sequencing dataset GSE153625 was used to examine differentially expressed genes (DEGs) of kidney tissues in IRI-AKI mice compared with sham mice.
Immunopharmacol Immunotoxicol
December 2024
Background: Triptolide (TP) has been confirmed to possess many beneficial functions including anti-inflammation and immunosuppression.
Objective: The present study aimed to explore the potential involvement of IL-2/IL-2R pathway in the immunosuppressive activities of TP.
Methods: Cultured CTLL-2 cells were utilized to evaluate the potential benefits of TP.