Publications by authors named "Jianzhuan Li"
As a biological macromolecule, the coat protein (CP) of potato virus Y (PVY) mediates the virus' primary pathogenic behaviors. It has been gradually realized that certain residues on the CP are crucial for functions such as virus particle movement and assembly. However, there are few reports of potential drugs successfully targeting these key residues with unique mechanisms of action.
View Article and Find Full Text PDFArticle Synopsis
- Researchers are exploring the potato virus Y (PVY) coat protein (CP) to understand how specific residues affect its ability to cause disease and to design antiviral drugs.
- A series of drug derivatives were created using a molecular hybridization strategy that targets a specific amino acid (Ser) in the CP, which is important for the virus's assembly process.
- The study found that a new compound can inhibit the virus's assembly by competing with the natural binding of Ser to viral RNA, paving the way for new antiviral therapies targeting PVY.
The unsatisfactory effects of conventional bactericides and antimicrobial resistance have increased the challenges in managing plant diseases caused by bacterial pests. Here, we report the successful design and synthesis of benzofuran derivatives using benzofuran as the core skeleton and splicing the disulfide moieties commonly seen in natural substances with antibacterial properties. Most of our developed benzofurans displayed remarkable antibacterial activities to frequently encountered pathogens, including pv (), pv (), and pv ().
View Article and Find Full Text PDF