Edible thermosensitive chitosan/hydroxypropyl β-cyclodextrin hydrogel with natural licoricidin for enhancing oral health: Biofilm disruption and demineralization prevention.

Dental caries, a widespread and significantly detrimental health condition, is characterized by demineralization, pain, compromised tooth functionality, and various other adverse effects. Licoricidin (LC), a natural isoflavonoid, demonstrates potent antimicrobial properties for maintaining oral health. However, its practical application is significantly hindered by its limited water solubility and susceptibility to removal within the oral environment.

Targeted pH-responsive chitosan nanogels with Tanshinone IIA for enhancing the antibacterial/anti-biofilm efficacy.

Persistent bacterial infection caused by biofilms is one of the most serious problems that threatened human health. The development of antibacterial agents remains a challenge to penetrate biofilm and effectively treat the underlying bacterial infection. In the current study, chitosan-based nanogels were developed for encapsulating the Tanshinone IIA (TA) to enhance the antibacterial and anti-biofilm efficacy against Streptococcus mutans (S.

Chitosan nanoparticles efficiently enhance the dispersibility, stability and selective antibacterial activity of insoluble isoflavonoids.

Natural isoflavonoids have attracted much attention in the treatment of oral bacterial infections and other diseases due to their excellent antibacterial activity and safety. However, their poor water solubility, instability and low bioavailability seriously limited the practical application. In this study, licoricidin-loaded chitosan nanoparticles (LC-CSNPs) were synthesized by self-assembly for improving the dispersion of licoricidin (LC) and strengthening antibacterial and anti-biofilm performance.

Effect of a novel interocclusal recording method on occlusal accuracy of implant-supported fixed prostheses: A randomized clinical trial.

Objectives: To investigate the effect of a novel interocclusal recording method on the occlusal accuracy of implant-supported fixed prostheses for partially dentate patients with distal extension.

Materials And Methods: Twenty patients with two or more adjacent teeth missing in the distal extension and scheduled to receive implant-supported fixed prostheses were enrolled. Two interocclusal recording methods were used: placing polyvinyl siloxane (PVS) on the interocclusal recording caps (test), and placing PVS on healing abutments (control).

Microbiological and clinical evaluation of ultrasonic debridement with/without erythritol air polishing during supportive periodontal therapy in arches with full-arch fixed implant-supported prostheses: protocol for a randomised controlled trial.

Introduction: Implant-supported prostheses are often successfully used in edentulous patients. However, the incidences of peri-implant mucositis and peri-implantitis increase over time. The accumulation of pathogenic bacteria adjacent to prostheses can induce peri-implant disease.

A review about the application of phonetic methods in deciding the jaws relation of complete denture.

Speech could be used, because it was a neuromuscular movement without teeth contact. The method was stable, however it was used more in vertical relation deciding. More study was needed in the horizontal relation deciding.

Accuracy of a milled digital implant surgical guide: An in vitro study.

Statement Of Problem: An accurate surgical template for guided implant surgery is essential for the success of an implant restoration. However, reports on the accuracy of digitally designed and computer numeric controlled (CNC) machine-milled surgical templates are sparse.

Purpose: The purpose of this in vitro study was to investigate the accuracy of an implant surgical guide digitally designed by using data from cone beam computed tomography (CBCT) scans and milled with a 5-axis CNC machine.

Comparison of peri-implant submucosal microbiota in arches with zirconia or titanium implant-supported fixed complete dental prostheses: a study protocol for a randomized controlled trial.

Background: The success rate of implant-supported prostheses for edentulous patients is relatively high. However, the incidence of biological complications, especially peri-implant mucositis and peri-implantitis, increases yearly after the placement of prostheses. The accumulation of pathogenic bacteria adjacent to a prosthesis is the main cause of biological complications.

Accuracy of implant surgical guides fabricated using computer numerical control milling for edentulous jaws: a pilot clinical trial.

Background: To evaluate the accuracy of a computer numerical control (CNC) milled surgical guide for implant placement in edentulous jaws.

Methods: Edentulous patients seeking implants treatment were recruited in this prospective cohort study. Radiographic guides with diagnostic templates were fabricated from wax-up dentures.

The Effectiveness of Waist-Shaped and Straight-Shaped Interdental Brushes in Cleaning Implant Overdenture Attachments: A Self-Controlled Clinical Trial.

Elderly patients often find it challenging to remove plaque accumulated on the attachments of implant overdentures (IODs) using conventional cleaning instruments. Further, excessive plaque accumulation can lead to peri-implant diseases and occasionally to respiratory diseases. Therefore, here, we aimed to compare the effectiveness of waist-shaped interdental brushes (WIBs) with that of straight-shaped interdental brushes (SIBs) in plaque removal from the locator attachments of IODs.

Early loading of splinted implants in posterior mandible: Three-year results of a prospective multicenter study.

Objective: To evaluate the clinical outcomes of an early loading protocol of splinted implants with a fluoride-modified nanostructure surface and a tapered apex design for the therapy of posterior partial edentulism of mandible.

Materials And Methods: One hundred and seven implants were placed in the mandible of 45 subjects at three centres in China. A minimum of two and a maximum of three implants were placed in an edentulous region using a one-stage protocol.

Closing open contacts adjacent to an implant-supported restoration.

Loss of interproximal contact between fixed implant-supported restorations and the adjacent teeth is one of the most common complications in implant dentistry. This article presents a clinical chairside technique for closing open contacts adjacent to an implant-supported restoration. A silicon model is perfused from a restoration-level impression using the open tray technique.

Passively fitting implant-supported complete-arch interim restoration.

This article presents a technique for fabricating a passively fitting implant-supported screw-retained complete-arch interim restoration with resistance to early fracture. Two gypsum casts were obtained from an implant impression using the splinting technique. The complete-arch interim restoration with abutment access holes, which was reinforced with a glass fiber splint, was fabricated on one cast and connected to restorative abutments on the other cast extraorally to eliminate stresses from the polymerization shrinkage of resin.

An implant impression technique involving abutment transition from interim prostheses to definitive restorations in the esthetic zone.

This article presents an impression technique involving transfer of the position of implants and the emergence profile of splinted interim prostheses fabricated on nonindexed interim abutments to definitive single crowns fabricated on indexed abutments.

[The modified lip-tooth-ridge classification: a guide for edentulous maxillary arches].

According to the width and height of the maxillary alveolar ridge, the maxillary edentulous jaws can be divided into three categories by using modified lip-tooth-ridge (MLTR) classification. Class Ⅰ is characterized by sufficient bone available for implants in the vertical and horizontal aspects and is suitable for fixed implant-supported prostheses. Class Ⅱ is characterized by sufficient bone amount available for implants in a horizontal aspect but insufficient for lip support and is suitable for a fixed detachable implant-supported prosthesis.

Effects of thermal treatment on the adhesion strength and osteoinductive activity of single-layer graphene sheets on titanium substrates.

In recent years, dental implants have become the preferred approach for the restoration of missing teeth. At present, most dental implants are made of pure titanium, and are affected by peri-implantitis and bone resorption, which usually start from the implant neck, due to the complex environment in this region. To address these issues, in this study we modified the surface of titanium (Ti) implants to exploit the antibacterial and osteoinductive effects of single-layer graphene sheets.

Effect of Voluntary Wheel Running on Striatal Dopamine Level and Neurocognitive Behaviors after Molar Loss in Rats.

The aim of the present study is to evaluate the effect of voluntary wheel running on striatal dopamine level and behavior of cognition and emotion in molar loss rats. Twenty-four Sprague-Dawley rats were enrolled in this study and randomly divided into following 4 groups: control group (C group), molar loss group (ML group), 1-week physical exercise before molar loss group (1W-ML group), and 4-week physical exercise before molar loss group (4W-ML group). The rats both in 4W-ML and 1W-ML groups were placed in the voluntary running wheel in order to exercise for 4 weeks and 1 week, respectively.

A digital technique for fabricating implant-supported interim restorations in the esthetic zone.

A digital technique for fabricating an implant-supported interim restoration is presented. The labial cervical architecture of the natural tooth is captured before extraction and registered to form the emergence profile of the interim restoration. A well-contoured interim restoration is fabricated before surgery and connected to the immediately placed implant with a customized interim abutment.

A digital technique for replicating peri-implant soft tissue contours and the emergence profile.

A digital technique is presented that records peri-implant soft tissue contours and the emergence profile. The architecture of interim restorations and adjacent teeth, the position of the implant, and the emergence profile of interim prostheses are scanned and registered to design a zirconia frame and to form a digital cast.

Single-Layer Graphene Enhances the Osteogenic Differentiation of Human Mesenchymal Stem Cells In Vitro and In Vivo.

In recent years, although several studies have demonstrated the potential of graphene-coated substrates in promoting attachment, proliferation and differentiation of osteoblasts and mesenchymal stem cells (MSCs), the effects of single-layer graphene on the osteogenic differentiation of human MSCs (hMSCs) remains unclear, especially in vivo. In this study, we transferred chemical vapor deposition (CVD) grown single-layer graphene to glass slides and observed its effects on adhesion, proliferation and osteogenic differentiation of human adipose-derived stem cells (hASCs) and human bone marrow mesenchymal stem cells (hBMMSCs) in vitro. Then, in vivo, we incubated hASCs and hBMMSCs on single-layer graphene-coated smooth titanium (Ti) disks before implanting them into the back subcutaneous area of nude mice.

Comparative in vitro study of cementing techniques for implant-supported restorations.

Statement Of Problem: Various techniques are used to cement implant-supported restorations. Excess residual cement is a concern.

Purpose: The purpose of this in vitro study was to evaluate 3 techniques for cementing implant-supported restorations.

Early loading of splinted implants in the posterior mandible: a prospective multicentre case series.

Aim: To evaluate the 12-months clinical and radiological outcomes with the OsseoSpeed(™) TX implant using an early loading protocol in patients with missing teeth in the posterior mandible.

Material And Methods: Forty-five subjects, with Kennedy class I or II edentulism in the mandible, were enrolled at three centres in China. Two or three implants were placed in one edentulous region using a one-stage procedure.

[Three-dimensional finite element analysis on half of the structure defect with post core and all-ceramic crown restoration of mandibular first molar].

Objective: To make a mechanical analysis on three-dimensional finite element models of the mandibular first molar defect restored with post core and all-ceramic crown, and to provide a guideline for planning restoration for such kind of tooth structure defect.

Methods: Cone-beam CT based three dimensional finite element models of post and core restored first mandibular molars were established, with 6 different ferrule designs (the ferrule with only 180 axial wall on different locations). The von Misses criterion was applied for comparing the maximum von Misses stress value of dentin and stress concentration areas in six models which restored with fiber post or cast NiGr alloy post core or Au alloy post core under the maximum, vertical, inclined and horizontal direct loads.

[Stability of phonetics to determine the horizontal jaw relation in healthy adults].

Objective: The aim of this study was to compare the mandibular position when speaking with the intercuspal position and to check the stability of phonetics when determining the horizontal jaw relation in healthy adults.

Methods: A total of 19 healthy volunteers were recruited. Seven Chinese letters, namely, /xi/, /er/, /yi/, /ci/, /mi/, /ni/, and /ri/, were chosen in the test.

The nanoscale geometry of TiO2 nanotubes influences the osteogenic differentiation of human adipose-derived stem cells by modulating H3K4 trimethylation.

Nanostructured materials can direct stem cell lineage commitment solely by their various, but controllable, geometric cues, which would be very important for their future application in bone tissue engineering and bone regeneration. However, the mechanisms by which nano-geometric cues dictate the osteogenic differentiation of stem cells remain unclear. Epigenetics is central to cellular differentiation, a process that regulates heritable and long-lasting alterations in gene expression without changing the DNA sequence.