Publications by authors named "Jianzhan Yang"
Article Synopsis
- - Rho family GTPases, particularly RhoA, are involved in promoting tumor growth and metastasis, making RhoA a potential target for cancer treatments, but developing effective drugs has been slow.
- - Researchers synthesized new compounds (benzo[ ]thiophene-3-carboxylic acid 1,1-dioxide derivatives) inspired by a previous RhoA inhibitor (DC-Rhoin), improving their anti-cancer properties through specific chemical modifications.
- - One compound, b19, was found to significantly reduce the growth, movement, and invasion of breast cancer cells (MDA-MB-231) while inducing cell death, with its effects linked to the inhibition of the RhoA/
Sixteen ceanothane-type triterpenoids, including four new compounds-hovendulcisic acids A-D (-) -were purified from the stems of Thunb. The structures of - were confirmed by comprehensive means including ECD and quantum chemical calculations. Putative biosynthetic pathways of - were proposed, and , , and exhibited antitumor activity on A549 and MDA-MB-231 cells.
View Article and Find Full Text PDFEthnopharmacological Relevance: Kaempferia galanga Linn. is an aromatic medicinal herb with extensively applied in India, China, Malaysia and other South Asia countries for thousands of years. It has been mentioned to treat abdominal tumors.
View Article and Find Full Text PDFHepatic fibrosis is a global health problem, which currently has no FDA approved antifibrotic therapy yet. This study aimed to explore the mechanism of Hovenia genus in the treatment of hepatic fibrosis by an integrative strategy combining network pharmacology analysis, molecular docking, transcriptomics and experimental validation. The traditional Chinese medicine systems pharmacology (TCMSP) database and literatures were used to collect the components of Hovenia genus.
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