A fluorogenic nitric oxide donor induced by yellow LED light for cells proliferation inhibition and imaging.

Nitric oxide (NO), as a vital cellular signalling molecule in physiological processes, has been found to play an important role in various biological functions. In this study, we rationally designed three NO donors by tethering nitrobenzene derivatives to three fluorescent chromophores. NX-NO was found to release NO and exhibit a high fluorescence turn-on signal ratio upon exposure to LED yellow light.

A novel chemiluminescent probe for hydrazine detection in water and HeLa cells.

Hydrazine is a substance harmful to humans and the environment, necessitating the development of a sensitive and specific detection method. Herein, a novel chemiluminescent probe based on Schaap's adamantylidene-dioxetane (CL-HZ) for detecting hydrazine was synthesized and evaluated. The probe was activated by the removal of a protecting group to form free phenoxy-dioxetane, when treated with hydrazine.

Late-Stage Direct o-Alkenylation of Phenols by Pd -Catalyzed C-H Functionalization.

o-Alkenylation of unprotected phenols has been developed by direct C-H functionalization catalyzed by Pd . This work features phenol group as a directing group and realizes highly site-selective C-H bond functionalization of phenols to achieve the corresponding products in moderate to excellent yields at 60 °C. The advantages of this reaction include unprecedented C-H functionalization using phenol as a directing group, high regioselectivity, good substrate scope, mild reaction conditions, and high efficiency.