Piperine induces autophagy of colon cancer cells: Dual modulation of AKT/mTOR signaling pathway and ROS production.

Background: Colorectal cancer (CRC) is a prevalent malignancy and poses a significant clinical challenge. Piperine, an alkaloid molecule extracted from Piper nigrum and Piper longum, has emerged as a promising anticancer agent. However, the molecular mechanisms of piperine' antitumor effects in CRC need to be further elucidated.

SIRT1 promotes glucolipid metabolic conversion to facilitate tumor development in colorectal carcinoma.

Fatty acid oxidation (FAO) is a major alternate energy metabolism pathway in tumor cells subjected to metabolic stress caused by glucose deficiency during rapid progression. However, the mechanism of metabolic reprogramming between glycolysis and FAO in tumor cells is unknown. Therefore, identifying the metabolic glucolipid conversion hub in tumor cells is crucial.

Cranial capacity measurement for modern Chinese adults based on 3D reconstruction.

Objectives: To determine the average modern adult cranial capacity in China, and assess the gender differences and trends in order to establish normal reference values and provide theoretical basis for individualized treatment in clinical practice.

Methods: We conducted a cross-sectional study between January 2019 to June 2020. Thin-slice (0.

Enhancement of the antioxidant abilities of lignin and lignin-carbohydrate complex from wheat straw by moderate depolymerization via LiCl/DMSO solvent catalysis.

A facile and environmentally-friendly strategy for increasing antioxidant activity is a crucial issue for value-added lignin and lignin-carbohydrate complex (LCC) as alternative antioxidants. However, the antioxidant activities of lignin and LCC by the traditional solid-liquid extraction (SLE) methods were restricted by the relatively lower solubility induced from high molecular weight (Mw), and the less functional groups including, phenolic hydroxyl and carboxyl. To improve the antioxidantion of lignin and LCC, lithium chloride/dimethyl sulfoxide (LiCl/DMSO) solvent fractionation (LDSF) was conducted to increase the functional groups and reduce Mw, in which LiCl/DMSO acted triple roles as solvent, acid, and metal chloride catalyst for the depolymerization reaction synchronously.

Efficient isolation of organosolv lignin-carbohydrate complexes (LCC) with high antioxidative activity via introducing LiCl/DMSO dissolving.

Lignin-carbohydrate complexes (LCC) have shown great potential as biocompatible antioxidants. But it is difficult to isolate LCC efficiently from lignocellulose by traditional Solid-Liquid Extraction method (SLE), which is blamed to the innate bioimpedance caused by the complex supramolecular structure of the lignocellulose, and a great mass transferring resistance between the extracting solution and solid lignocellulose. To release these restrictions above and improve the efficiency of LCC isolation, a modified isolating method named Liquid-Liquid Extraction (LLE) was proposed, in which ball-milled wheat stalk was dissolved in lithium chloride/dimethyl sulfoxide (LiCl/DMSO) solution, then regenerated by dioxane aqueous to extract LL-LCCs.

Fabrication of thermo-sensitive lignocellulose hydrogels with switchable hydrophilicity and hydrophobicity through an SIPN strategy.

Herein, thermo-sensitive lignocellulose hydrogels with varying lignin contents were fabricated with -isopropylacrylamide (NIPAAm) by a semi-interpenetrating polymer network (SIPN) strategy using a LiCl/DMSO solvent system. Soda lignin mixed with the lignocellulose/LiCl/DMSO solution was also used to prepare the composite hydrogels, and the influence of the existential state of lignin on the hydrogel properties was analyzed objectively. The SIPN hydrogels exhibited more favorable mechanical properties due to the physical entanglement of poly-NIPAAm and lignocellulose.

Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells.

Metabolic reprogramming endows cancer cells with the ability to adjust metabolic pathways to support heterogeneously biological processes. However, it is not known how the reprogrammed activities are implemented during differentiation of cancer stem cells (CSCs). In this study, we demonstrated that liver CSCs relied on the enhanced mitochondrial function to maintain stemness properties, which is different from aerobic glycolysis playing main roles in the differentiated non-CSCs.

[Evaluation of intraductal papillary mucinous neoplasms of the pancreas on MDCT and MRI].

Objective: The purpose of our study was to evaluate the predictive factors of the presence of invasive carcinoma associated with intraductal papillary mucinous neoplasm (IPMN) of the pancreas on MDCT and MRI.

Methods: Preoperative MDCT or/and MRI of 27 consecutive patients (19 men, 8 women, mean age 61.3 years) who had undergone surgical resection and had a pathological diagnosis of IPMN were retrospectively assessed.