Numerical Prediction and Experimental Validation of Deposited Filaments in Direct Ink Writing: Deposition Status and Profile Dimension.

The deposition status and profile dimension of deposited filaments have an impact on the quality of the printed parts fabricated by direct ink writing (DIW). Previous works often failed to realize the full quantitative characterizations of the detailed influence of the process parameters on the deposition status and profile dimension. Herein, we predict and analyze the deposition status and profile dimension by proposing an improved three-dimensional (3D) numerical model.

miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer.

MicroRNA (miRNA/miR)-124 is a miRNA, which exerts tumor suppressive effects but is frequently absent in tumors. Although it has been validated to target oncogenic genes such as signal transducer and activator of transcription 3, forkhead box Q1, and Slug, the mechanistic link between miR‑124 and potential target genes that contribute to tumor progression, is yet to be investigated. IQ motif containing GTPase activating protein 1 (IQGAP1) is a scaffold protein that participates in protein‑protein interactions and integrating diverse signaling pathways.