Construction of metal-organic framework-based multienzyme system for L-tert-leucine production.

Chiral compounds are important drug intermediates that play a critical role in human life. Herein, we report a facile method to prepare multi-enzyme nano-devices with high catalytic activity and stability. The self-assemble molecular binders SpyCatcher and SpyTag were fused with leucine dehydrogenase and glucose dehydrogenase to produce sc-LeuDH (SpyCatcher-fused leucine dehydrogenase) and GDH-st (SpyTag-fused glucose dehydrogenase), respectively.

Whole-genome sequencing and phylogenomic analyses of a novel zearalenone-degrading B72.

Unlabelled: strain B72 was previously isolated as a novel zearalenone (ZEN) degradation strain from the oil field soil in Xinjiang, China. The genome of B72 was sequenced with a 400 bp paired-end using the Illumina HiSeq X Ten platform. De novo genome assembly was performed using SOAPdenovo2 assemblers.

Engineered living materials grown from programmable mycelial pellets.

The development of engineered living materials (ELMs) has recently attracted significant attention from researchers across multiple disciplines. Fungi-derived ELMs represent a new type of macroscale, cost-effective, environmentally sustainable materials. However, current fungi-based ELMs either have to undergo a final process to heat-kill the living cells or rely on the co-culture with a model organism for functional modification, which hinders the engineerability and versatility of these materials.

Recent advances in the construction of biocomposites based on fungal mycelia.

In recent years, environmental problems have become increasingly serious, significantly effecting the ecosystem and human health. To deal with the problem of environmental pollution in an eco-conscious way, sustainable composite biomaterials are being produced. Mycelium-based composite biomaterials combine biological systems with substrates such as nanomaterials or agricultural and industrial wastes, which can complement each other's advantages or turn waste into a useful resource.