Development and validation of a deep learning model for morphological assessment of myeloproliferative neoplasms using clinical data and digital pathology.

The subjectivity of morphological assessment and the overlapping pathological features of different subtypes of myeloproliferative neoplasms (MPNs) make accurate diagnosis challenging. To improve the pathological assessment of MPNs, we developed a diagnosis model (fusion model) based on the combination of bone marrow whole-slide images (deep learning [DL] model) and clinical parameters (clinical model). Thousand and fifty-one MPN and non-MPN patients were divided into the training, internal testing and one internal and two external validation cohorts (the combined validation cohort).

A Paper-Based Fluorescent Sensor for Rapid Early Screening of Oral Squamous Cell Carcinoma.

Various types of sensors play an irreplaceable role in the detection of biomarkers, but their high cost and complicated operation make it difficult to benefit ordinary people. Herein, we develop a low-cost, double-layered, paper-based fluorescent sensor (CP/HQ) structurally consisting of the upper reaction layer loaded with two oxidases (lactate oxidase and choline oxidase) and the bottom fluorescent layer that physically associates with the porphine-grafted composite fluorescent polymer colloids (PF-PDMTP/HQ). Based on the dramatic and rapid fluorescence decrease of porphine induced by the oxidation between saliva and oxidases and subsequent fluorescence resonance energy transfer from oxidized hydroquinone, the resultant fluorescent paper sensor enables us to achieve visual detection of OSCC, which was further recognized by smartphone scanning as the grayscale variation.

Ocular biometrics and uncorrected visual acuity for detecting myopia in Chinese school students.

The study is to evaluate the performance of ocular biometric measures and uncorrected visual acuity (UCVA) for detecting myopia among Chinese students. Among 5- to 18-year-old Chinese students from two cities of China, trained eye-care professionals performed assessment of ocular biometrics (axial length (AL), corneal curvature radius (CR), anterior chamber depth) under noncycloplegic conditions using NIDEK Optical Biometer AL-Scan, distance visual acuity using retro-illuminated logMAR chart with tumbling-E optotypes, and cycloplegic refractive error using NIDEK autorefractor with administration of 0.5% tropicamide.

Clinical Outcomes After Primary Implantation into Modified One-and-a-Half-Barrel Fibula Free Flap Reconstructed Mandible.

Purpose: The aim of this study was to introduce and evaluate a modified one-and-a-half-barrel fibular technique guided by occlusion for functionally reconstructing mandibular defects.

Materials And Methods: Fifteen patients underwent mandibular reconstruction with the modified one-and-a-half-barrel technique and simultaneous insertion of dental implants. A vascularized fibular segment was used to reconstruct the alveolar ridge of the neomandible with dental implants loaded simultaneously.

Optimizing the Intercrystallite Connection of a Donor-Acceptor Conjugated Semiconductor Polymer by Controlling the Crystallization Rate via Temperature.

The charge carrier transport of conjugated polymer thin film is mainly decided by the crystalline domain and intercrystallite connection. High-density tie-chain can provide an effective bridge between crystalline domains. Herein, the tie-chain connection behavior is optimized by decreasing the crystal region length (l ) and increasing the crystallization rate.

Recent Structural Engineering of Polymer Semiconductors Incorporating Hydrogen Bonds.

Highly planar, extended π-electron organic conjugated polymers have been increasingly attractive for achieving high-mobility organic semiconductors. In addition to the conventional strategy to construct rigid backbone by covalent bonds, hydrogen bond has been employed extensively to increase the planarity and rigidity of polymer via intramolecular noncovalent interactions. This review provides a general summary of high-mobility semiconducting polymers incorporating hydrogen bonds in field-effect transistors over recent years.

Prediction for Cycloplegic Refractive Error in Chinese School Students: Model Development and Validation.

Purpose: To predict cycloplegic refractive error using measurements obtained under noncycloplegic conditions.

Method: Refractive error was measured in 5- to 18-year-old Chinese students using a NIDEK autorefractor before and after administration of 0.5% tropicamide.

Effect of Cycloplegia on Refractive Error Measure in Chinese School Students.

Purpose: To determine differences in cycloplegic vs. non-cycloplegic refractive error and factors associated with these differences in Chinese school students.

Method: In this cross-sectional school-based study, refractive error was measured in school students using a NIDEK autorefractor before and after administration of 0.

Use of anterior ramus bone graft for mandibular reconstruction in elderly patients.

In this study, we investigated the feasibility of using a geometrically designed anterior ramus graft to reconstruct lateral mandibular defects. This was achieved by assessing the anatomical dimensions of the mandibular ramus on computed-tomographies. The design sequence and application of the graft was also demonstrated using one of our cases.

growth of large-area and self-aligned graphene nanoribbon arrays on liquid metal.

Intrinsic graphene features semi-metallic characteristics that limit its applications in electronic devices, whereas graphene nanoribbons (GNRs) are promising semiconductors because of their bandgap-opening feature. However, the controllable mass-fabrication of high-quality GNR arrays remains a major challenge. In particular, the growth of GNR arrays through template-free chemical vapor deposition (CVD) has not been realized.

[Clinical application and accuracy analysis of occlusion-guided functional mandibular reconstruction].

Objective: To investigate the influence of the design and application of novel surgical template on the accuracy of reconstructed mandibula and implant position in occlusion-guided functional mandibular reconstruction, so as to provide guidance for clinical treatment.

Methods: Between January 2017 and May 2019, 11 patients with segmental mandible defects were treated, including 8 males and 3 females with an average age of 31.8 years (range, 19-45 years).

Influence of Backbone Regioregularity on High-Mobility Conjugated Polymers Based on Alkylated Dithienylacrylonitrile.

We designed and synthesized two donor-acceptor type conjugated polymers, the regioirregular polymer RI-PDPP-CNTVT-6 and its regioregular counterpart RR-PDPP-CNTVT-6, based on diketopyrrolopyrrole (DPP) and alkylated dithienylacrylonitrile (CNTVT) units. Among them, the 2-decyltetradecyl side chain on the DPP acceptor unit and the hexyl side chain on the CNTVT donor unit were used to ensure enough solubility for them. The backbone regioregularity was used to tune electronic structures and carrier transport of the conjugated system.

Multisubstituted Azaisoindigo-Based Polymers for High-Mobility Ambipolar Thin-Film Transistors and Inverters.

Ambipolar semiconducting materials have great potential in complementary-like organic logic circuits. Accessing such logic circuits demands balanced hole and electron mobilities. However, the lack of ambipolar high-mobility polymer semiconductors with balanced charge carrier-transporting properties precludes the rapid development of organic logic circuits.

[Association of GPER gene polymorphism with social function of children with attention deficit hyperactivity disorder].

Objective: To assess the association of G protein-coupled estrogen receptor(GPER) gene polymorphism with social function of children with attention deficit hyperactivity disorder (ADHD).

Methods: The social function of 135 children with ADHD were assessed by Weiss Functional Impairment Scale-Parent form (WFIRS-P). The coding region of GPER gene of all patients was subjected to Sanger sequencing.

Bis-Diketopyrrolopyrrole Moiety as a Promising Building Block to Enable Balanced Ambipolar Polymers for Flexible Transistors.

A bis-diketopyrrolopyrrole (DPP dimer, 2DPP) core is synthesized with much stronger electron deficiency than DPP by homocoupling of DPP. 2DPP-based polymers, P2DPP-BT, P2DPP-TT, P2DPP-TVT, and P2DPP-BDT, are obtained. Top-gated organic field-effect transistors on plastic substrate are fabricated.

Thiazole-Flanked Diketopyrrolopyrrole Polymeric Semiconductors for Ambipolar Field-Effect Transistors with Balanced Carrier Mobilities.

In this paper we report three thiazole-flanked diketopyrrolopyrrole-based donor-acceptor alternating copolymers as new ambipolar semiconductors and their field-effect transistor devices with balanced hole and electron mobilities. Nitrile groups are introduced into the polymer backbone, and the substituent effect on electronic structures is studied. Different side chains are also involved to tune the interdigitation of the polymers.

Tracking the Evolution of Polymer Interface Films during the Process of Thermal Annealing at the Domain and Single Molecular Levels using Scanning Tunneling Microscopy.

Structural evolution of polymer (NTZ12) interface films during the process of annealing is revealed at the domain and single molecular levels using the statistical data measured from scanning tunneling microscopy images and through theoretical calculations. First, common features of the interface films are examined. Then, mean values of surface-occupied ratio, size and density of the domain are used to reveal the intrinsic derivation of the respective stages.

Normal platelet counts mask abnormal thrombopoiesis in patients with chronic myeloid leukemia.

Increased platelet heterogeneity has been reported in myeloproliferative neoplasms (MPN) with thrombocytosis. However, whether abnormal thrombopoiesis occurs in patients with chronic myeloid leukemia (CML) who have normal platelet counts, remains unclear. In order to explore this question, 25 patients with CML with normal platelet counts (CML-N), 40 patients with CML with elevated platelet counts (CML-E) and 33 healthy adults were recruited.

Novel butterfly-shaped fused heteroacenes: synthesis, properties, and device performance of solution-processed field-effect transistors.

Two tetrabrominated intermediates obtained by bromination of naphthodithiophene in different solvents were used to construct novel highly π-extended butterfly-shaped heteroarenes 1-6, containing either an 8- or 10-fused ring. The solution-processed organic field-effect transistors based on compound 1 exhibited promising device performance with a hole mobility of 0.072 cm(2) V(-1) s(-1) and a current on/off ratio of 10(6) under ambient atmosphere.

Dibenzoannelated tetrathienoacene: synthesis, characterization, and applications in organic field-effect transistors.

Two structural isomers of six-fused-ring sulfur-containing molecules were synthesized as active materials for p-type organic field-effect transistors, and their optical and electrochemical properties were characterized. Field-effect transistors based on these compounds were fabricated to investigate the relationships between structures and semiconductor properties.