Publications by authors named "Jianxun Liu"
Introduction: Ischemic stroke greatly threatens human life and health. Neuro-restoration is considered to be the critical points in reestablishing neurological function and improving the quality of life of patients. Catalpol is the main active ingredient of the Chinese herbal medicine , which has the beneficial efficacy in traditional remedy, is closely related to the mitochondrial morphology and function.
View Article and Find Full Text PDFTo explore the regulation of vasodilatory function in rats with post-infarction heart failure by salvianolic acid B(Sal-B) based on the mechanosensitive ion channel, namely Piezo1. A post-infarction heart failure model of rats was prepared by ligation of the left anterior descending coronary artery. After successful modeling, the rats were randomly divided into the model group, Sal-B group(0.
View Article and Find Full Text PDFBackground: Sleep disorder is widespread and involves a variety of intricate factors in its development. Sleep deprivation is a manifestation of sleep disorder, can lead to energy metabolism disturbances, weakened immune system, and compromised body functions. In extreme situations, sleep deprivation can cause organ failure, presenting significant risks to human health.
View Article and Find Full Text PDFAtherosclerosis is a major contributor to cardiovascular diseases and mortality globally. The progression of atherosclerotic disease results in the expansion of plaques and the development of necrotic cores. Subsequent plaque rupture can lead to thrombosis, occluding blood vessels, and end-organ ischemia with consequential ischemic injury.
View Article and Find Full Text PDFBackground And Aim: Salidroside (SA) is the main active component of L., with potential in treating cardiovascular and cerebrovascular diseases and cerebral ischemia. However, its efficacy and mechanism in cerebral ischemia remain unclear, particularly regarding its effect on glutamate (Glu) metabolism.
View Article and Find Full Text PDFArticle Synopsis
- Buyang Huanwu Decoction (BYHWD) is a traditional Chinese medicine used for treating qi deficiency and blood stasis, and the study explores its effects on platelet activation and heart function following myocardial infarction (MI).
- In an experiment on rats with induced MI, five groups were compared, including those treated with different dosages of BYHWD, to assess improvements in heart function and platelet behavior.
- Results indicated that BYHWD effectively reversed cardiac dysfunction and fibrosis, reduced platelet hyperreactivity, minimized inflammation, and showed changes in key signaling pathways related to platelet activation and heart health.
Article Synopsis
- Cytokine storm (CS) is a major factor causing severe respiratory issues in COVID-19 patients, transforming mild cases into life-threatening conditions.
- Vaccines are effective at preventing serious illness, but there are still limited treatment options for those severely affected or hospitalized.
- Chinese herbal medicines show potential as complementary treatments to reduce symptoms of ARDS and target the critical molecular pathways involved, though more extensive research is needed to confirm their effectiveness and understand how they work.
Article Synopsis
- * MIRI is mainly caused by oxidative stress from reactive oxygen species (ROS), which disrupts cellular balance and causes significant cell damage, inflammation, and dysfunction in heart cells.
- * Recent studies have made progress in understanding oxidative stress in heart injury, but the protective effects of Traditional Chinese Medicine (TCM) against this damage during blood flow restoration remain largely unexamined.
Article Synopsis
- * A multicenter, randomized, placebo-controlled trial will involve 288 stroke patients divided into four groups to evaluate various outcome measures over several weeks.
- * The findings aim to provide clinical evidence on whether SMES combined with NGF improves stroke recovery, focusing on motor function, cognitive assessment, and changes in brain activity.
Article Synopsis
- * A new system was developed using a suspended twisted stacking metasurface and PbS quantum dots, showing strong optical chirality and high dissymmetry in circular polarization.
- * This technique allows manipulation of light emission by changing the surrounding medium's refractive index, paving the way for applications in anticounterfeiting, biosensing, and advanced imaging technologies.
Article Synopsis
- InGaN-based long wavelength laser diodes (LDs) on silicon are crucial for advancements in laser display and lighting technologies.
- Effective interface engineering of InGaN multi-quantum wells (MQWs) is critical to prevent issues like photon scattering and internal absorption losses that limit the lasing wavelength.
- This study reports improvements in the morphology and interface sharpness of InGaN layers using a graded-composition waveguide and a thin AlGaN layer, leading to the successful fabrication of a cyan LD emitting at 480 nm with a low threshold current density of 18.3 kA/cm.
Article Synopsis
- The study aimed to understand protein molecular mechanisms behind two Traditional Chinese Medicine (TCM) subtypes of coronary artery disease (CAD) - stagnation and blood stasis syndrome (QS) and deficiency and blood stasis syndrome (QD) - after patients underwent a procedure called percutaneous coronary intervention (PCI).
- A total of 438 CAD patients (227 with QS and 211 with QD) participated, with serum samples analyzed for protein changes before and after PCI using label-free quantification proteomics.
- Findings indicated significant biochemical and proteomic changes in both groups post-PCI, with specific proteins and pathways related to inflammation and lipid metabolism being altered, highlighting distinct intervention mechanisms for each CAD subtype.
Article Synopsis
- Qilong capsule (QC), derived from the traditional Chinese Buyang Huanwu Decoction, aims to treat myocardial ischemia-reperfusion injury (MIRI) by addressing Qi deficiency and blood stasis, although its effects on MIRI were previously unclear.
- The study investigated QC's protective effects on platelet function in rats with MIRI by analyzing various blood properties and signaling pathways after ligation and reperfusion of the left anterior descending artery.
- Results indicated that QC reduced blood viscosity and platelet activation, linking its protective effects to the inhibition of the CD36 pathway and suggesting that it alleviates hemorheological disorders caused by MIRI.
Article Synopsis
- This study investigated how tetrahydropalmatine (THP) protects heart cells from damage caused by hypoxia/reoxygenation (H/R) injury by inhibiting mitophagy through specific cellular pathways (ULK1/FUNDC1).
- H9c2 heart cells were used to model H/R injury, and various methods were employed to evaluate cell viability, mitochondrial function, and the expression of key proteins related to autophagy and apoptosis.
- Results showed that THP improved mitochondrial health by lowering reactive oxygen species levels, enhancing ATP production, and reducing cell death, suggesting that it achieves this by inhibiting autophagy and decreasing apoptosis.
Article Synopsis
- The article examines how ginsenoside Re helps protect H9c2 cells from hypoxia/reoxygenation (H/R) injury by regulating mitochondrial biogenesis through a specific pathway involving Nrf2, HO-1, and PGC-1α.
- The study found that ginsenoside Re improves cell activity and reduces oxidative stress markers like superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, and reactive oxygen species levels after H/R injury.
- It also demonstrated that ginsenoside Re enhances mitochondrial function by improving mitochondrial membrane potential, decreasing permeability, and increasing key protective protein expressions, ultimately reducing apoptosis-related signals in the cells.
Article Synopsis
- Diffractive optical elements are useful for miniaturizing and integrating optical systems, commonly used for applications like beam shaping and imaging, but most are not adjustable which limits their use.
- The research presents a tunable diffractive optical element made with a gold microarray on a flexible liquid crystal elastomer substrate, which changes its structure when illuminated by a 532 nm laser.
- This innovative design allows for the control of diffraction patterns and shows promise for various adaptable photonic devices, including filters, couplers, and holographic displays.
Article Synopsis
- - Yi-Qi-Tong-Luo Granules (YQTLs) are a traditional Chinese medicine approved by the CFDA, shown to be effective in aiding recovery after cerebral infarction by promoting remyelination.
- - The study used a rat model of brain injury to assess YQTLs' effects on cognitive functions and neurological damage through various tests and analyses, leading to the identification of 141 differential metabolites, including improvements in GABA levels.
- - YQTLs enhanced neurotrophin production, increased expression of remyelination-associated proteins, and stimulated signaling pathways associated with neuron health and repair, indicating a strong therapeutic potential for cerebral ischemia recovery.
[Role of macrophage polarization in pulmonary diseases and intervention of traditional Chinese medicines].
Zhongguo Zhong Yao Za Zhi
January 2024
Article Synopsis
- Macrophages are crucial immune cells that help maintain balance in the lung environment and can change into two types: M1 (pro-inflammatory) and M2 (anti-inflammatory), influencing pulmonary diseases.
- The paper discusses how the polarization of these macrophages, affected by various signaling molecules, relates to conditions like asthma, chronic obstructive pulmonary disease, acute lung injury, and pulmonary fibrosis.
- It also reviews advancements in using traditional Chinese medicine (TCM) to regulate macrophage polarization, highlighting its potential in managing lung inflammation and inspiring future clinical research.
Article Synopsis
- * Research shows that PNS enhances the proliferation and differentiation of neural stem cells (NSCs), protects against brain injuries, and activates the mTOR signaling pathway.
- * In vitro studies indicate that PNS improves the survival, differentiation, and synaptic plasticity of C17.2 NSCs after simulated ischemic injury, with mTOR signaling playing a key role in these processes.
Article Synopsis
- - SSNX is a traditional Chinese medicine used to treat myocardial ischemia-reperfusion injury (MIRI), which has shown promise in reducing cardiovascular events, though its specific mechanisms in protecting microvascular injury are not fully understood.
- - The study aims to explore how SSNX protects the microvasculature in rats and whether this protection is linked to the NR4A1/Mff/Drp1 pathway during I/R injury.
- - Various experimental methods, including histological staining, Western blotting, and cell culture models, were employed to assess cardiac function, evaluate microvascular health, and investigate the underlying molecular mechanisms involving mitochondrial function.
Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases.
Front Cardiovasc Med
December 2023
Article Synopsis
- Cardiomyocytes cannot regenerate after birth and primarily grow in size instead of dividing, leading to scar tissue formation when they die, which affects heart function.
- Regenerating cardiomyocytes is crucial for maintaining healthy cardiac development, and various biological factors are involved in this complex process.
- The Nkx2.5 transcription factor is key for cardiac progenitor cell development, but its exact role in heart regeneration remains unclear, making it a target for further research in cardiac treatment.
[Baicalin improves inflammatory response of human microglia by regulating cAMP-PKA-NF-κB/CREB pathway].
Zhongguo Zhong Yao Za Zhi
November 2023
Article Synopsis
- - This study examines how baicalein (BAI) affects inflammatory responses in human microglial cells (HMC3) induced by lipopolysaccharide (LPS) and its potential therapeutic benefits for ischemic stroke through the cAMP-PKA-NF-κB/CREB pathway.
- - Researchers tested various doses of BAI on LPS-induced inflammation in HMC3 cells, measuring key indicators of oxidative stress and inflammatory markers, and found that BAI improved cell health and reduced inflammation at certain concentrations.
- - The study highlights the promise of BAI as a treatment derived from traditional Chinese medicine for cerebral ischemic diseases by showing its ability to protect against inflammation and promote cell recovery.
Article Synopsis
- Shuangshen Ningxin Capsule (SSNX) is a traditional Chinese medicine made from various herbal components and has been shown to offer protection against myocardial ischemia, although its exact mechanism is not fully understood.
- In a study involving rats with myocardial ischemia-reperfusion injury, SSNX significantly improved heart function and reduced damage to cardiac tissues, with the protective mechanism further investigated through advanced metabolomics techniques.
- The research indicates that SSNX may work by normalizing myocardial energy metabolism and modifying the distribution of specific lipids and phospholipids, which helps stabilize heart cell membranes and reduces injury severity.
Due to the unique self-acceleration, self-healing, and non-diffraction properties, Airy beams have been explored extensively and found applications in various fields. It has been proven as an essential aspect to tune the trajectory of Airy beams for extensive applications. In this paper, we propose a method based on liquid crystal (LC) alignment with metasurfaces, which enables dynamic tuning of the trajectory of Airy beams.
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- Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that significantly impacts patients' lives and contributes to mortality, with Traditional Chinese Medicine (TCM) showing promise in managing its effects.
- A systematic review of studies from various databases found that TCM interventions notably improved various health metrics such as body weight, heart function, and lipid levels in animal models of DCM.
- The analysis identified factors like the type of TCM used, intervention duration, modeling methods, and animal species as sources of variability in the results, highlighting the need for further investigation in this area.