Publications by authors named "Jianxun Kan"
Ubiquitination, a crucial post-translational modification, plays a role in nearly all physiological processes. Its functional execution depends on a series of catalytic reactions involving numerous proteases. TRIM26, a protein belonging to the TRIM family, exhibits E3 ubiquitin ligase activity because of its RING structural domain, and is present in diverse cell lineages.
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- Ectopic fat accumulation, particularly in the stomach, contributes to metabolic dysfunction linked to obesity, prompting a study of 190 sleeve gastrectomy patients to examine gastric submucosal fat levels.* -
- Patients were split into two groups based on the extent of fat accumulation, with significant differences in metabolic risk factors like body mass index (BMI) and insulin resistance (IR) observed between the groups.* -
- The analysis suggested that higher levels of BMI and IR are associated with increased gastric fat accumulation, with IR identified as an independent risk factor for this condition in obese patients.*