A novel method for preparing Eligulstat through chiral resolution.

Eliglustat is a ceramide glucosyltransferase inhibitor work as first line oral therapy for adults with Gaucher disease type 1 (a rare disease) at present. Although the eliglustat in enantiomerically pure forms is obtained by asymmetric syntheses, the reported methods suffer from many limits when it comes to industrial applications. Therefore, the preparation of a racemic mixture followed by resolution can still be a viable and straightforward alternative, especially when it could be adapted to large scale.

Ag/Pyridine Co-Mediated Oxidative Arylthiocyanation of Activated Alkenes.

An efficient Ag/pyridine co-mediated oxidative arylthiocyanation of activated alkenes via radical addition/cyclization cascade process was developed. This reaction could be carried out under mild conditions to provide biologically interesting 3-alkylthiocyanato-2-oxindoles in good to excellent yields. Mechanistic studies suggested a unique NCS• radical addition path and clarified the dual roles of catalytic pyridine as base and crucial ligand to accelerate the oxidation of Ag(I) to Ag(II), which is likely oxidant responsible for the formation of NCS• radical.

Investigation on Microstructure of Beetle Elytra and Energy Absorption Properties of Bio-Inspired Honeycomb Thin-Walled Structure under Axial Dynamic Crushing.

The beetle elytra requires not only to be lightweight to make a beetle fly easily, but also to protect its body and hind-wing from outside damage. The honeycomb sandwich structure in the beetle elytra make it meet the above requirements. In the present work, the microstructures of beetle elytra, including biology layers and thin-walled honeycombs, are observed by scanning electron microscope and discussed.

Energy absorption characteristics of bio-inspired honeycomb column thin-walled structure under impact loading.

Beetles have developed the elytra that are interesting and impressive strategy for thriving in their native environments. The elytra, although formed from simple biopolymer constituents, take on many effective designs. In present work, internal structure of elytra is discussed and three bionic structures named as the bio-inspired honeycomb column thin-walled structure (BHTS) are proposed.

Effects of micro-structure on aerodynamics of Coccinella septempunctata elytra (ladybird) in forward flight as assessed via electron microscopy.

The effects of micro-structure on aerodynamics of Coccinella septempunctata (Coleoptera: Coccinellidae) elytra in forward flight were investigated. The micro-structure was examined by a scanning electron microscope and a digital microscope. Based on the experimental results, five elytron models were constructed to separately investigate the effects of the camber and the local corrugation in both leading edge and trailing edge on aerodynamics.

Functional morphology and structural characteristics of wings of the ladybird beetle, Coccinella septempunctata (L.).

In recent years, the surface morphology and microstructure of ladybird (Coccinella septempunctata) wings have been used to help design the flapping-wing micro air vehicle (FWMAV). In this study, scanning electron microscopy (SEM) was used to verify the functional roles of the ladybird forewing and hindwing. Surface morphology and the cross-sectional microstructure of the wings are presented.