The novel circRNA circ_0045881 inhibits cell proliferation and invasion by targeting mir-214-3p in triple-negative breast cancer.

Background: Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer (BC). The circRNA-miRNA‒mRNA axis is a promising biomarker for the early diagnosis and prognosis of BC. However, the critical circRNA mediators involved in TNBC progression and the underlying regulatory mechanism involved remain largely unclear.

Study on web pillar failure mechanism during auger mining and its associated risk assessment.

To safely and efficiently recover trapped coal under final endwalls in open cut mines, theoretical analysis and numerical calculation were used to study the stability of web pillar during auger mining. The partial ordered set (poset) evaluation model was used to develop a risk assessment methodology, and auger mining at Pingshuo Antaibao open cut coal mine was used as a field example for validation. Based on the catastrophe theory, the failure criterion of web pillar was established.

CircRNA circSEPT9 Downregulates miR-10a through Methylation to Promote Cell Proliferation in Laryngeal Squamous Cell Carcinoma.

The oncogenic functions of circRNA circSEPT9 have been characterized in triple-negative breast cancer. We analyzed its role in laryngeal squamous cell carcinoma (LSCC). Quantitative reverse-transcription PCR (RT-qPCR) was used to analyze the expression of circSEPT9 and miR-10a in paired LSCC and nontumor tissues donated by 50 patients with LSCC.

P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC.

Background: Skeletal muscle atrophy and fibrosis are pathological conditions that contribute to morbidity in numerous conditions including aging, cachexia, and denervation. Muscle atrophy is characterized as reduction of muscle fiber size and loss of muscle mass while muscle fibrosis is due to fibroblasts activation and excessive production of extracellular matrix. Purinergic receptor P2Y2 has been implicated in fibrosis.

Changes in surface characteristics and adsorption properties of 2,4,6-trichlorophenol following Fenton-like aging of biochar.

Fenton-like system formed in a natural soil environment deemed to be significant in the aging process of biochar. Aged biochars have distinct physico-chemical and surface properties compared to non-aged biochar. The aged biochar proved to be useful soil amendment due to its improved elements contents and surface properties.

Insights into the effects of long-term biochar loading on water-soluble organic matter in soil: Implications for the vertical co-migration of heavy metals.

Although interest in biochar remediation is growing, the effects of long-term biochar loading on soil environments have not been clearly confirmed. The contents and characteristics of water-soluble organic matter (WSOM) from soils after eight years of biochar remediation were investigated, and the vertical co-migration of heavy metals controlled by interactions between WSOM, soil and contaminants were also analyzed. The results showed that biochar-leaching WSOM featured high aromaticity.

Main branch of ACN-to-RLN for management of laryngospasm due to unilateral vocal cord paralysis.

Objectives/hypothesis: This study explored the feasibility and efficiency of main branch of ansa cervicalis nerve (ACN)-to-recurrent laryngeal nerve (RLN) anastomosis for management of paroxysmal laryngospasm due to unilateral vocal cord paralysis (UVCP).

Methods: Thirteen patients who underwent main branch of ACN-to-RLN anastomosis for management of paroxysmal laryngospasm due to UVCP were enrolled in the present study. Multidimensional assessments, including videostroboscopy, voice assessment, and laryngeal electromyography (LEMG), were performed preoperatively and postoperatively.

Characteristics of organo-mineral complexes in contaminated soils with long-term biochar application.

Long-term studies on the environmental effects following biochar additions to soils, while plentiful, are predominantly focused on the soil fertility, whereas few are on the soil organo-mineral complexes. This study examines the changes of organo-mineral complexes in an acidic paddy soil and a saline-alkali soil which were remediated using biochar for approximately 8 years and 3 years, respectively. The results showed that loosely combined humus increased by 30.

Effects of laboratory biotic aging on the characteristics of biochar and its water-soluble organic products.

Effects of biotic aging on the characteristics of biochar and its water-soluble organic products were determined through a one-year laboratory incubation study. Biochar had a positive influence on microbial population size. Without microbial addition, biochars showed little change, except for an obvious increase in oxygen content from 3.

Effects of Wet Oxidation Process on Biochar Surface in Acid and Alkaline Soil Environments.

Biochar has been studied for remediation of heavy metal-contaminated soils by many researchers. When in external conditions, biochar in soils ages, which can transform its structural properties and adsorption capacity. This study was conducted with two oxidation processes, HNO₃/H₂SO₄ and NaOH/H₂O₂, to simulate the effects of biochar in acid and alkaline soil conditions.

Effects of chemical oxidation on surface oxygen-containing functional groups and adsorption behavior of biochar.

Biochar is a beneficial soil amendment but the changes in its surface properties during the aging process, especially the oxygen-containing functional groups and the associated adsorption behaviors, are not well documented. In this paper, the aged wheat straw biochar was simulated by chemical oxidation with HNO-HSO and NaOH-HO systems. Characterization results showed that carbon loss and oxygen incorporation ran throughout the aging process.