The novel miR_146-Tfdp2 axis antagonizes METH induced neuron apoptosis and cell cycle abnormalities in tree shrew.

Methamphetamine (METH) is a synthetic drug with potent addictive, relapse, and neurotoxic properties. METH abuse contributes to severe damage to the central nervous system, potentially causing cognitive impairments, behavioral changes, and neurodegenerative diseases. METH-induced neuronal damage is closely related to apoptosis and cell cycle abnormalities, while gene expression regulator microRNAs (miRNAs) may play extensive roles in this progress, but the specific mechanisms remain unclear.

Restoration of follicular β-catenin signaling by mesenchymal stem cells promotes hair growth in mice with androgenetic alopecia.

Background: The use of mesenchymal stem cells (MSCs) is recognized as a promising strategy for the treatment of androgenetic alopecia (AGA). However, the underlying mechanism remains to be explored. Here, we evaluated the therapeutic effects and potential mechanisms of the use of human umbilical cord mesenchymal stem cells (hUCMSCs) in dihydrotestosterone (DHT)-induced AGA models in vivo and in vitro.

Recent Progress of Three-Dimensional Graphene-Based Composites for Photocatalysis.

Converting solar energy into fuels/chemicals through photochemical approaches holds significant promise for addressing global energy demands. Currently, semiconductor photocatalysis combined with redox techniques has been intensively researched in pollutant degradation and secondary energy generation owing to its dual advantages of oxidizability and reducibility; however, challenges remain, particularly with improving conversion efficiency. Since graphene's initial introduction in 2004, three-dimensional (3D) graphene-based photocatalysts have garnered considerable attention due to their exceptional properties, such as their large specific surface area, abundant pore structure, diverse surface chemistry, adjustable band gap, and high electrical conductivity.

Obacunone improves dihydrotestosterone-induced androgen alopecia by inhibiting androgen receptor dimerization.

Background: Dihydrotestosterone-induced androgen receptor activation and nuclear translocation was identified as the key event in androgen alopecia, which led to dermal papilla cell damage and hair growth cycle arrest. Inhibiting androgen receptor activation or nuclear translocation thus represents a potential therapeutic strategy for reducing dermal papilla cell damage and treating androgen alopecia.

Purpose: To evaluate the effects of obacunone androgen alopecia and explore the potential underlying mechanisms.

Macrophage autophagy protects against acute kidney injury by inhibiting renal inflammation through the degradation of TARM1.

Macroautophagy/autophagy activation in renal tubular epithelial cells protects against acute kidney injury (AKI). However, the role of immune cell autophagy, such as that involving macrophages, in AKI remains unclear. In this study, we discovered that macrophage autophagy was an adaptive response during AKI as mice with macrophage-specific autophagy deficiency () exhibited higher serum creatinine, more severe renal tubule injury, increased infiltration of ADGRE1/F4/80 macrophages, and elevated expression of inflammatory factors compared to WT mice during AKI induced by either LPS or unilateral ischemia-reperfusion.

Hybrid-Microstructure-Based Soft Network Materials with Independent Tunability of Mechanical Properties over Large Deformations.

Introducing auxetic metamaterials into stretchable electronics shows promising prospects for enhancing the performance and innovating the functionalities of various devices, such as stretchable strain sensors. Nevertheless, most existing auxetics fail to meet the requirement of stretchable electronics, which typically include high mechanical flexibility and stable Poisson's ratio over large deformations. Moreover, despite being highly advantageous for application in diverse load-bearing conditions, achieving tunability of J-shaped stress-strain response independent of negative Poisson's ratio remains a significant challenge.

TLR3 Agonist Amplifies the Anti-Inflammatory Potency of ADSCs via IL-10-Mediated Macrophage Polarization in Acute Pancreatitis.

The immunoregulatory role of mesenchymal stem cells (MSCs) in inflammation is heterogeneous and can exhibit anti-inflammatory or proinflammatory properties depending on the microenvironment. We herein observed that the activation of Toll-like receptor 3 (TLR3) by polyinosinic : polycytidylic acid (poly(I : C)) stimulation facilitated the transformation of adipose-derived stem cells (ADSCs) into an anti-inflammatory phenotype. The enhanced anti-inflammatory properties were assessed in a taurocholate-induced pancreatitis model.

Cooperative Adaptive Command Filtered Backstepping Control for EVs to UPS-Microgrid via Virtual Synchronous Generator.

Multiple batteries in uninterruptible power supply (UPS)-microgrid systems based on multiagents composed of multiple electric vehicles (EVs) can encounter state of charge (SoC) consistency problems. To solve this differential expansion and controller saturation problem, an adaptive command filter sliding-mode control strategy based on virtual synchronous generators (VSGs) and considering the power allocation principle is proposed. First, based on directed graph theory, an SoC consistency algorithm and power allocation strategy for multiple EVs were proposed, forming a dc power system with a fixed communication topology.

Iontronic Dynamic Sensor with Broad Bandwidth and Flat Frequency Response Using Controlled Preloading Strategy.

Rapid advancements in human-machine interaction and voice biometrics impose desirability on soft mechanical sensors for sensing complex dynamic signals. However, existing soft mechanical sensors mainly concern quasi-static signals such as pressure and pulsation for health monitoring, limiting their applications in emerging wearable electronics. Here, we propose a hydrogel-based soft mechanical sensor that enables recording a wide range of dynamic signals relevant to humans by combining a preloading design strategy and iontronic sensing mechanism.

Interleaved coding Janus metasurface with independent transmission and reflection phase modulation.

An interleaved coding Janus metasurface is proposed, which can generate bidirectional functionalities with full phase control of the reflected and transmitted waves. By introducing rotation and geometric parameter changes into the meta-atoms, the reflection and transmission channels with required energy distribution and foci are realized. More remarkably, our approach is based on a single metasurface design that arranges two types of unidirectional propagating unit structures with simultaneous desired reflection and transmission properties into a checkerboard configuration to obtain four different holograms.

Improving Robustness of Intent Detection Under Adversarial Attacks: A Geometric Constraint Perspective.

Deep neural networks (DNNs)-based natural language processing (NLP) systems are vulnerable to being fooled by adversarial examples presented in recent studies. Intent detection tasks in dialog systems are no exception, however, relatively few works have been attempted on the defense side. The combination of linear classifier and softmax is widely used in most defense methods for other NLP tasks.

Oxygen excess ratio control of PEM fuel cell systems with prescribed regulation time.

In this paper, we focus on addressing the air supply problem for fuel cells. The air supply system faces a challenge: operating at maximum load consumes a significant amount of power, while insufficient air can lead to oxygen starvation problems in fuel cells. An important metric, the oxygen excess ratio, indicates whether the fuel cell is receiving the appropriate amount of air.

Evaluation of the potential of recovering various valuable elements from a vanadiferous titanomagnetite tailing based on chemical and process mineralogical characterization.

In order to evaluate the potential of recovering various valuable elements from vanadiferous titanomagnetite tailing (VTMT), the chemical and process mineralogical characterization of VTMT were investigated in this study by various analytical techniques such as XRF, XRD, optical microscopy, SEM, EDS, and AMICS. It was found that VTMT is a coarser powder in general; about 50% of the particle size is greater than 54.30 μm.

On Hierarchical Multi-UAV Dubins Traveling Salesman Problem Paths in a Complex Obstacle Environment.

This article aims to solve a hierarchical multi-UAV Dubins traveling salesman problem (HMDTSP). Optimal hierarchical coverage and multi-UAV collaboration are achieved by the proposed approaches in a 3-D complex obstacle environment. A multi-UAV multilayer projection clustering (MMPC) algorithm is presented to reduce the cumulative distance from multilayer targets to corresponding cluster centers.

Tectonic and orbital forcing of the South Asian monsoon in central Tibet during the late Oligocene.

The modern pattern of the Asian monsoon is thought to have formed around the Oligocene/Miocene transition and is generally attributed to Himalaya-Tibetan Plateau (H-TP) uplift. However, the timing of the ancient Asian monsoon over the TP and its response to astronomical forcing and TP uplift remains poorly known because of the paucity of well-dated high-resolution geological records from the TP interior. Here, we present a precession-scale cyclostratigraphic sedimentary section of 27.

Adaptive generalized super twisting sliding mode control for PMSMs with filtered high-gain observer.

This paper proposes a novel adaptive-gain generalized super twisting algorithm for permanent magnet synchronous motors. The stability of this algorithm is strict proof using the Lyapunov method. Both controllers of the speed-tracking loop and the current regulation loop are designed according to the proposed adaptive-gain generalized super twisting algorithm.

Designing Hierarchical Soft Network Materials with Developable Lattice Nodes for High Stretchability.

Soft network materials (SNMs) represent one of the best candidates for the substrates and the encapsulation layers of stretchable inorganic electronics, because they are capable of precisely customizing the J-shaped stress-strain curves of biological tissues. Although a variety of microstructures and topologies have been exploited to adjust the nonlinear stress-strain responses of SNMs, the stretchability of most SNMs is hard to exceed 100%. Designing novel high-strength SNMs with much larger stretchability (e.

Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity.

Pancreatic β-cell compensation is a major mechanism in delaying T2DM progression. Here we report the abnormal high expression of circGlis3 in islets of male mice with obesity and serum of people with obesity. Increasing circGlis3 is regulated by Quaking (QKI)-mediated splicing circularization.

A bibliometrics and visualization analysis of cannabidiol research from 2004 to 2021.

Cannabidiol, a non-psychoactive component extracted from the plant cannabis sativa, has gained growing focus in recent years since its extensive pharmacology effects have been founded. The purpose of this study intends to reveal the hot spots and frontiers of cannabidiol research using bibliometrics and data visualization methods. A total of 3,555 publications with 106,793 citations from 2004 to 2021 related to cannabidiol were retrieved in the Web of Science database, and the co-authorships, research categories, keyword burst, and reference citations in the cannabidiol field were analyzed and visualized by VOSviewer and Citespace software.

Optical Rail Surface Crack Detection Method Based on Semantic Segmentation Replacement for Magnetic Particle Inspection.

Railway damage detection is of great significance in ensuring railway safety. The cracks on the rail surface play a key role in studying the formation and development process of rail damage, predicting the occurrence of rail defects, and then improving the service life of the rail. However, due to the small shape of the cracks, the typical detection method is relatively complicated, and the speed is quite slow.

Stabilization With Prescribed Instant for High-Order Integrator Systems.

This article develops a new controller design approach to stabilize system states onto the equilibrium at an arbitrarily selected time instant irrespective of the initial system states and parameters. By the stabilization approach, the actual convergence time (not the bound of actual convergence time) is independent of the initial value of system states. This feature differentiates our proposed prescribed-instant stability from conventional fixed, predefined, and prescribed time stability.

Cannabidiol attenuates methamphetamine-induced conditioned place preference in male rats and viability in PC12 cells through the Sigma1R/AKT/GSK3β/CREB signaling pathway.

Methamphetamine use is associated with several negative consequences, including neurotoxicity and greater probability of exhibiting a substance use disorder. Sigma1 receptor is involved in the neurobiological basis of several drug use disorders. Cannabidiol has received attention in the treatment of drug use disorders and neurotoxicity.