Publications by authors named "Jianxing Cheng"
Cryptorchidism, commonly known as undescended testis, affects 1%-9% of male newborns, posing infertility and testis tumor risks. Despite its prevalence, the detailed pathophysiology underlying male infertility within cryptorchidism remains unclear. Here, we profile and analyze 46,644 single-cell transcriptomes from individual testicular cells obtained from adult males diagnosed with cryptorchidism and healthy controls.
View Article and Find Full Text PDF[Retrospective study on the impact of penile corpus cavernosum injection test on penile vascular function].
Beijing Da Xue Xue Bao Yi Xue Ban
August 2024
Article Synopsis
- The study aimed to evaluate how age, hormonal levels, and biochemical markers influence vascular function in men with erectile dysfunction (ED), using data from patients who underwent specific tests at a medical center from 2020 to 2023.
- Out of 700 patients analyzed, significant findings revealed that those with vascular ED had lower estrogen and testosterone levels and a higher incidence of hyperglycemia compared to non-vascular ED patients.
- Regression analysis indicated that higher estrogen levels acted as a protective factor against vascular ED, while older age and elevated glucose levels were associated with increased risk for different types of ED.
Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction.
Free Radic Biol Med
March 2024
Diabetes mellitus (DM) is a widespread metabolic disease presenting with various complications, including spermatogenic dysfunction. However, the underlying mechanisms are still unclear. Ferroptosis, a novel type of programmed cell death, is associated with much metabolic diseases.
View Article and Find Full Text PDFBackground: Infertility is a prevalent global condition, and emerging reproductive technologies may enhance its evaluation and treatment. Understanding the current features of randomized clinical trials in infertility is crucial for improving study design and ensuring the translation of results for patient benefits.
Objectives: To investigate the primary characteristics of randomized clinical trials related to infertility and areas where require improvement.
Article Synopsis
- Genetic studies have highlighted the importance of Phf7 in animal germline development, but the link between Phf7 mutations and male infertility needs more exploration.
- Using Phf7 knockout mice, researchers confirmed that infertility is linked to genetic defects preventing the proper transition from histones to protamines and that immune pathways activated by endogenous retroviruses play a role.
- The study identifies PPARα as a potential target for managing inflammation in the testis and suggests that the antioxidant astaxanthin could be a promising treatment for male infertility by restoring immune regulation affected by Phf7 loss.
Background: Aging-related fertility decline is a prevalent concern globally. Male reproductive system aging is mainly characterized by a decrease in sperm quality and fertility. While it is known that intestinal physiology changes with age and that microbiota is shaped by physiology, the underlying mechanism of how the microbiota affects male reproductive aging is still largely unexplored.
View Article and Find Full Text PDFBackground: The ubiquitin ligase HECT, UBA, and WWE domain-containing E3 ubiquitin protein ligase 1 is essential for the establishment and maintenance of spermatogonia. However, the role of HECT, UBA, and WWE domain-containing E3 ubiquitin protein ligase 1 in regulating germ cell differentiation remains unclear, and clinical evidence linking HECT, UBA, and WWE domain-containing E3 ubiquitin protein ligase 1 to male infertility pathogenesis is lacking.
Objective: This study aims to investigate the role of HUWE1 in germ cell differentiation and the mechanism by which a HUWE1 single nucleotide polymorphism increases male infertility risk.
Purpose: Our previous studies showed that nanotechnology improves derived adipose-derived stem cells (ADSCs) therapy for erectile dysfunction (ED). In this study, the Neuregulin-1(NRG1) gene was transfected into ADSCs with superparamagnetic iron oxide nanoparticles (SPION) further to improve the therapeutic effect of ADSCs on ED.
Materials And Methods: ADSCs were isolated from epididymal adipose tissue of Sprague-Dawley rats.