Effectiveness and Safety of Dupilumab for Prurigo Nodularis in China: A Multicentric and Observational Study.

Background: The efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established in clinical trials, but there is a lack of multicenter data regarding its effectiveness and safety in real-world settings.

Methods: Patients with moderate-to-severe PN who initiated dupilumab treatment between July 2023 and January 2024, with a follow-up period of at least 16 weeks at 10 hospitals in China were included. We used peak pruritus numeric rating scale (PP-NRS), investigator global assessment (IGA) for PN, and dermatology life quality index for adults or children (DLQI/CDLQI) to assess disease control status and quality of life impairment, and monitored adverse events to assess the safety.

Nitrogen fertilization and soil nitrogen cycling: Unraveling the links among multiple environmental factors, functional genes, and transformation rates.

Anthropogenic nitrogen (N) inputs substantially influence the N cycle in agricultural ecosystems. However, the potential links among various environmental factors, nitrogen functional genes, and transformation rates under N fertilization remain poorly understood. Here, we conducted a five-year field experiment and collected 54 soil samples from three 0-4 m boreholes across different treatments: control, N-addition (nitrogen fertilizer) and NPK-addition (combined application of nitrogen, phosphorus and potassium fertilizers) treatments.

Ethnobotanical studies on rice landraces under on-farm conservation in Xishuangbanna of Yunnan Province, China.

Background: A complex interaction and mutual influence exists among landscapes, cultures, and landraces, with rice culture being a typical embodiment of this relationship. The conservation of landraces operates alongside preserving traditional practices. The Xishuangbanna region stands out as a hub for the genetic diversity of landraces, boasting rich genetic resources.

Optimized Charge/Hydrophobicity Balance of Antimicrobial Peptides Against Polymicrobial Abdominal Infections.

Antimicrobial peptides (AMPs) potentially serve as ideal antimicrobial agents for the treatment of polymicrobial abdominal infections due to their broad-spectrum antimicrobial activity and excellent biocompatibility. However, the balance of chain length, positive charges, and hydrophobicity on the antimicrobial activity of AMPs are still far from being optimal. Herein, a series of AMPs ([KX]-NH, X = Ile, Leu or Phe, n = 3, 4, 5, or 6) with varied charges and hydrophobicity for the treatment of polymicrobial abdominal infections are designed.

Growth of 3D-TNAs@Ti-MOFs by dual titanium source strategy with enhanced photoelectrocatalytic/photoelectro-Fenton performance for degradation of tetracycline under visible light irradiation.

Visible-light-active 3D-TNAs@Ti-MOFs composite electrodes were fabricated by decorating nanoscaled Ti-based metal-organic frameworks on three-dimensional TiO nanotube arrays (3D-TNAs) prepared by a facile solvothermal method. The photoelectrocatalytic performance of electrode materials was evaluated by degradation of tetracycline (TC) under visible light irradiation. The experiment results show that Ti-MOFs nanoparticles are highly distributed on the top and side walls of TiO nanotubes.

Dupilumab for treatment of severe atopic dermatitis accompanied by lichenoid amyloidosis in adults: Two case reports.

Background: Lichenoid amyloidosis (LA) is a subtype of primary cutaneous amyloidosis characterized by persistent multiple groups of hyperkeratotic papules, usually on the lower leg, back, forearm, or thigh. LA may be associated with several skin diseases, including atopic dermatitis (AD). The treatment of LA is considered to be difficult.

Pembrolizumab combined with axitinib in the treatment of skin metastasis of renal clear cell carcinoma to nasal ala: A case report.

Background: Renal clear cell carcinoma (RCC) is a malignant tumor of the genitourinary system with a predilection for males. The most common metastatic sites are the lung, liver, lymph nodes, contralateral kidney or adrenal gland, however, skin metastasis has only been seen in 1.0%-3.

Fast Capture and Efficient Removal of Bloom Algae Based on Improved Dielectrophoresis Process.

A dielectrophoresis (DEP) method for direct capture and fast removal of was established in this work. The factors affecting the removal efficiency of were investigated systematically, leading to optimized experimental conditions and improved DEP process equipment. The experimental results showed that our improved DEP method could directly capture in eutrophic water with much enhanced removal efficiency of from high-concentration algal bloom-eutrophication-simulated solution.

Effect of metal pollution on the distribution and co-occurrence pattern of bacterial, archaeal and fungal communities throughout the soil profiles.

Metal pollution has raised negative impact on microbes, but little is known about the distribution and co-occurrence pattern of bacterial, fungal and archaeal communities along the soil profiles at multiple metal contamination sites. Here, we characterized the variations of metal concentrations and microbial communities with soil depth along five deep bores at the Tanghe Sewage Reservoir, a typical metal contamination area on the North China Plain. Co, Cd, Mg, Se, and Li were identified as the major contaminants in this area, and the pollution load index was 1.

Magnetic-Transition-Metal Oxides Modified Pollen-Derived Porous Carbon for Enhanced Absorption Performance.

In our work, the transition-metal-oxide precursor (TMO@BC, M = Fe, Co, Ni) has been loaded on the pollen carbon by the hydrothermal method and annealed at different temperatures to generate a composite material of metal oxide and pollen carbon in this study, which can effectively prevent agglomeration caused by a small size and magnetism. The XRD patterns of the samples showed that the as-synthesized metal oxides were γ-FeO, CoO, and NiO. In the 20 mg/L methyl orange adsorption experiment, the adsorption amount of CoO@C at 500 ℃ reached 19.

Global trends in the incidence of psoriasis from 1990 to 2019.

Background: The global, regional, and national burden of psoriasis was investigated based on the Global Burden of Disease (GBD) study.

Objectives: To report the incidence of psoriasis in 204 countries and territories from 21 regions according to age, sex, region, country, and socialdemographic index (SDI) between 1990 and 2019.

Materials & Methods: Estimates from the GBD 2019 study were used to analyse the incidence of psoriasis at the global, regional, and national levels.

Electrochemical Oxidation of Landfill Leachate after Biological Treatment by Electro-Fenton System with Corroding Electrode of Iron.

Electrochemical oxidation of landfill leachate after biological treatment by a novel electrochemical system, which was constructed by introducing a corroding electrode of iron (Fe) between a boron-doped diamond (BDD) anode and carbon felt (CF) cathode (named as BDD-Fe-CF), was investigated in the present study. Response surface methodology (RSM) with Box-Behnken (BBD) statistical experiment design was applied to optimize the experimental conditions. Effects of variables including current density, electrolytic time and pH on chemical oxygen demand (COD) and ammonia nitrogen (NH-N) removal efficiency were analyzed.

Highly Efficient Removal of Nitrate and Phosphate to Control Eutrophication by the Dielectrophoresis-Assisted Adsorption Method.

The removal of excessive amounts of nitrate and phosphate from water sources, especially agricultural wastewater, has been of high significance to control eutrophication in aquatic systems. Here, a new method is reported for the removal of nitrate and phosphate simultaneously from wastewater based on the combination of the solution-phased adsorption (ADS) and dielectrophoresis (DEP) techniques. The plant ash was first selected as the adsorbent by screening tests, followed by a systematic investigation of using the adsorbent to remove nitrate and phosphate from wastewater under various experimental conditions, including the testing of adsorbent dosage, pretreatment time, water flow rate, and electrode voltage.

Effect of glucose metabolism disorders on the short-term prognosis in neonates with asphyxia: a multicenter study in Hubei Province, China.

Objectives: To study the effect of glucose metabolism disorders on the short-term prognosis in neonates with asphyxia.

Methods: A retrospective analysis was performed on the medical data of the neonates with asphyxia who were admitted to 52 hospitals in Hubei Province of China from January to December, 2018 and had blood glucose data within 12 hours after birth. Their blood glucose data at 1, 2, 6, and 12 hours after birth (with an allowable time error of 0.

Two cases of refractory erythrodermic psoriasis effectively treated with secukinumab and a review of the literature.

Erythrodermic psoriasis (EP), which accounts for 1 to 2.25% of all psoriatic cases, typically occurs in patients with poor control of existing psoriasis. Secukinumab yields rapid and sustained improvements of signs and symptoms in patients with plaque psoriasis.

Three cases report of idiopathic angiosarcoma of the head and neck and literature review.

Herein, we reported 3 cases of angiosarcoma (AS) of the head and neck in old patients, and the etiology, pathogenesis, histopathology, immunohistochemistry, diagnosis, differential diagnosis and prognosis were discussion. Case 1, a male patient aged 86 years old was admitted due to purplish erythema on the head and face and progressive purplish edema in the orbit of the eye for 3 years. He was misdiagnosed with connective tissue disease in another hospital, and a second biopsy and histopathological examination confirmed the AS of the head and neck.

Electrochemical oxidation of sulfamethoxazole in BDD anode system: Degradation kinetics, mechanisms and toxicity evaluation.

In the present study, electrochemical oxidation of sulfamethoxazole (SMX) with Boron-doped Diamond (BDD) anode and Stainless Steel (SS) cathode was investigated systematically. The effects of current density, initial pH, supporting electrolyte and natural organic matter (NOM) on SMX degradation were explored. Under the conditions of current density 30 mA cm, 0.

Effects of Cyclosporine on Palmoplantar Pustulosis and Serum Expression of IL-17, IL-23, and TNF-α.

Introduction: This study aimed to investigate the effects of cyclosporine on palmoplantar pustulosis (PPP) and serum expression of IL-17, IL-23, and TNF-α.

Methods: Patients with PPP (n = 48) were recruited and treated with cyclosporine alone. The Palmoplantar Pustulosis Area and Severity Index score was obtained, and ELISA was employed to detect the serum IL-17, IL-23, and TNF-α expression before treatment and after 8 weeks of treatment.

Highly efficient removal of ammonia nitrogen from wastewater by dielectrophoresis-enhanced adsorption.

A new approach, based on dielectrophoresis (DEP), was developed in this work to enhance traditional adsorption for the removal of ammonia nitrogen (NH-N) from wastewater. The factors that affected the removal efficiency were systematically investigated, which allowed us to determine optimal operation parameters. With this new method we found that the removal efficiency was significantly improved from 66.

Maximization of current efficiency for organic pollutants oxidation at BDD, Ti/SnO-Sb/PbO, and Ti/SnO-Sb anodes.

Whereas electrochemical oxidation is noted for its ability to degrade bio-refractory organics, it has also been incorrectly criticized for excessive energy consumption. The present paper rectifies this misunderstanding by demonstrating that the energy actually consumed in the degradation process is much less than that wasted in the side reaction of oxygen evolution. To minimize the side reaction, the possible highest instantaneous current efficiency (PHICE) for electrochemical oxidation of phenol at Boron-doped Diamond (BDD), Ti/SnO-Sb/PbO (PbO), and Ti/SnO-Sb (SnO) anodes has been investigated systematically, and found to reach almost 100% at the BDD anode compared with 23% at the PbO anode and 9% at the SnO anode.

[Chemical constituents, biological activities and clinical applications of artemisia rupestris].

Artemisia rupestris is a traditional medicine in Uygur and Kazak in Xinjiang Province, mainly distributed in the territory of Xinjiang Altai area, Tianshan mountains and the Kunlun mountains, growing at an altitude of 1 500 to 4 000 meters of grassland and forest areas. As the broad research on chemical constituents, pharmacological activity, the effective components of A. rupestris have attracted the interest to make up new drugs.