Predictive Value of ERCC1 mRNA Level from Receiver-Operator Characteristic and Pretreatment EBV-DNA Virus Load in Stage II Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy with Concurrent Cisplatin.

The molecular mechanisms underlying chemoresistance are still poorly understood in nasopharyngeal cancer. The protein expression of ERCC1 in DNA repair genes has been reported related to resistance platinum and predicting treatment outcomes in various malignant carcinomas, but the benefit for predicting outcomes with optimal cutoff value of ERCC1mRNA is controversial. The level of plasma Epstein-Barr virus (EBV) DNA is positively correlated with clinical stages of nasopharyngeal carcinoma (NPC).

HS-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice.

Purpose: This thesis was to investigate the protective effect and mechanism of HS-mediated aerobic exercise on the antagonism of the hippocampus inflammatory response in CUMS-depressed mice.

Method: Seventy C57BL/6 mice were randomly divided into control group (CG), model control group (MG), model exercise group (ME), HS enhanced group (HG) and HS enhanced and exercise group (HE). All mice except CG underwent a 28-day CUMS depression model.