Publications by authors named "Jianxin Leng"
Article Synopsis
- Muscle satellite cells (MuSCs) are essential for muscle growth and repair, and primary pig MuSCs (pMuSCs) serve as a key model for research in pig muscle development.
- Long-term culture of pMuSCs loses their stemness, which hampers research; to solve this, scientists created immortalized pMuSCs (SV40 T-pMuSCs) using a lentiviral vector that allows them to be cultured for over 40 generations.
- SV40 T-pMuSCs show similar growth to primary cells initially but have slightly reduced differentiation potential, which can be improved by silencing SV40 T-antigen expression, making them a valuable resource for studying pig skeletal muscle.
