Publications by authors named "Jianxia Xiong"
Psoriasis is a chronic inflammatory skin condition characterized by erythematous plaques with white scales. Its pathogenesis is closely linked to oxidative stress and an imbalance in Th1/Th2 immune responses. Current treatments for psoriasis, such as topical agents, systemic therapies and phototherapy, frequently fail to achieve complete remission in clinical settings.
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- Psoriasis is a chronic skin disease that often occurs alongside autoimmune conditions like Graves' disease (GD), making treatment complex.
- A 34-year-old woman with both refractory psoriasis and GD experienced worsening skin symptoms after trying various treatments, including adalimumab and secukinumab.
- Ultimately, switching to guselkumab led to significant improvement in her psoriasis, suggesting it could be an effective option for patients with both conditions.
In this study we aimed to investigate the prevalence of SARS-CoV-2 infection in psoriasis patients, and outcomes of SARS-CoV-2 infection and associated risk factors. A cross-sectional survey was conducted from February 2023 to March 2023. Information was obtained with online questionnaire about psoriasis patients on demographic characteristics, clinical characteristics, SARS-CoV-2 infection and outcomes, vaccination, and routine protection against COVID-19.
View Article and Find Full Text PDFRosacea is a chronic inflammatory skin disorder that significantly impairs quality of life, however, its pathophysiology is still unclear. Previous studies have suspected that the bacterial -microbiome plays a causative role in the disease. To investigate whether there are differences in the abundance and diversity of facial bacterial microbiomes between rosacea patients and healthy controls.
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- Toxic epidermal necrolysis (TEN) is a serious skin condition affecting over 30% of the body that poses a high risk of death and can include severe systemic symptoms.
- TNF-α inhibitors like etanercept have shown promise in treating TEN, even in patients with serious infections, as seen in a study of three adults successfully treated despite having conditions like tuberculosis and septicemia.
- While results were positive and no new infections or adverse effects occurred during follow-up, more extensive studies are needed to confirm the effectiveness of TNF-α inhibitors in these cases.
Background And Objective: Previous studies have shown that patients with psoriasis are at higher risk of developing chronic kidney disease (CKD) and end-stage renal disease (ESRD) compared with general population; however, data on the differences in the occurrence of CKD and ESRD between patients with psoriasis and non-psoriatic controls are limited and inconsistent. The aim of this study was to carry out a comparison of the probability of suffering CKD and ESRD in patients with or without psoriasis by conducting a meta-analysis of cohort studies.
Methods: Cohort studies on PubMed, Web of Science, Embase and Cochrane Library by March, 2023 were searched for.
Article Synopsis
- Ankylosing spondylitis (AS) is a long-term inflammatory disease affecting the spine and joints, often treated with biologic therapies like TNF-ɑ inhibitors.
- These treatments can sometimes cause unexpected side effects, such as paradoxical palmoplantar pustulosis, which is a skin condition that can worsen the patient's situation.
- A case study of a 45-year-old male showed that after unsuccessful TNF-ɑ treatment, switching to ixekizumab led to significant improvement in both his skin condition and back pain, suggesting it could be a viable alternative for similar cases.
Analysis of the Efficacy and Recurrence of Omalizumab Use in the Treatment of Chronic Spontaneous Urticaria and Chronic Inducible Urticaria.
Int Arch Allergy Immunol
July 2023
Introduction: Chronic urticaria (CU) is a common skin condition that can be divided into chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). Omalizumab is one treatment option for CU, but currently there are limited clinical studies of omalizumab's efficacy for treating CU in Chinese patients. This study sought to investigate the efficacy and safety of omalizumab treatment for CU patients in a Chinese patient population.
View Article and Find Full Text PDFBackground: Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade malignant soft tissue tumor characterized by rosette-like infiltrative growth. Postoperative recurrence of this tumor is very common.
Aim: To evaluate the risk factors related to recurrence after wide local excision (WLE) of DFSP and to guide clinical diagnosis and treatment.
Background: Lichen simplex chronicus (LSC) is an acquired chronic dermatosis that is often accompanied by severe paroxysmal pruritus, and its pathogenesis to date is still unclear. Transient receptor potential channel A1 (TRPA1) is a non-selective cation channel. TRPA1 is widely expressed in skin, sensory neurons, and various other tissues, along with various biological functions and activation mechanisms.
View Article and Find Full Text PDFAnaplastic thyroid carcinoma (ATC) responds for the majority of death of thyroid carcinoma and often causes chemotherapy resistance. We investigated the influence of circEIF6 (Hsa_circ_0060060) on the cisplatin-sensitivity in papillary thyroid carcinoma (PTC) and ATC cells, and explored its regulation to downstream molecules miR-144-3p and Transforming Growth Factor α (TGF-α). Differentially expressed circRNAs in PTC were analyzed using the GSE93522 data downloaded.
View Article and Find Full Text PDFBackground: We investigated the influence of miR-144 on the cisplatin-sensitivity of anaplastic thyroid carcinoma (ATC) cells and explored the internal molecular mechanism of miR-144.
Methods: Thyroid cancer cells ARO, TPC1 and normal thyroid cells HT-ori3 were used in this research. Expressions of miR-144 and TGF-α were uncovered by western blot and qRT-PCR.