Heat shock protein 70 (HSP70) is a class of important molecular chaperones that are involved in protein folding, stabilization, and maturation, and play a vital role in plant growth and response to environmental stress. Apple trees frequently suffer from different-degree salt stress, which seriously affects their growth, quality, and yield. However, whether HSP70 genes are involved in salt tolerance is unexplored in apple.
View Article and Find Full Text PDFMolecular design plays a crucial role in regulating the photophysical properties and photodynamic therapy (PDT) performance of photosensitizers (PSs); however, realizing PDT-based synergistic therapy based on sole PSs is still rarely reported. Herein, three near-infrared red type I PSs (named TP1, TP2, and TP3) were synthesized by adjusting their electron acceptors. The results demonstrated that these PSs exhibited aggregation-enhanced reactive oxygen species (ROS) generation efficiency and cyano groups on PSs can reduce ROS generation in solution while achieving efficient PDT-based synergistic therapy in cells glutathione depletion.
View Article and Find Full Text PDFSalinity stress is a significant environmental factor that impacts the growth, development, quality, and yield of crops. The 2OG-Fe (II) oxygenase family of enzyme proteins plays crucial roles in plant growth and stress responses. Previously, we identified and characterized MdCo, which encodes a putative 2OG-Fe (II) oxygenase, a key gene for controlling the columnar growth habit of apples.
View Article and Find Full Text PDFHalogenated Organic Phosphate Esters (OPEs) are commonly found in plasticizers and flame retardants. However, they are one kind of persistent contaminants that can pose a significant threat to human health and ecosystem as new environmental estrogen. In this study, two representative halogenated OPEs, tris(1,3-dichloro-2-propyl) phosphate (TDCP) and tris(2,3-dibromopropyl) phosphate (TDBP), were selected as experimental subjects to investigate their interaction with human serum albumin (HSA).
View Article and Find Full Text PDFHarvest maturity significantly affects the quality of apple fruit in post-harvest storage process. Although the regulatory mechanisms underlying fruit ripening have been studied, the associated epigenetic modifications remain unclear. Thus, we compared the DNA methylation changes and the transcriptional responses of mature fruit (MF) and immature fruit (NF).
View Article and Find Full Text PDFAn amphiphilic fluorescent probe (BHSMP) with aggregation-induced emission (AIE) features was synthesized a one-step route. The probe showed high water dispersibility, low toxicity and the ability of selective and sensitive (limit of detection of 0.11 µM) detection of ClO with fast-response (≤30 s) in aqueous solution and living organisms.
View Article and Find Full Text PDFHerein, a fluorescent probe (named TPACP) with aggregation-induced emission (AIE) feature was developed and utilized for the selective detection of Cu with high sensitivity and fast-response. The resultant TPACP@Cu complexes from coordination of TPACP with Cu can also be potentially applied for chemodynamic and photodynamic therapy.
View Article and Find Full Text PDFChitosan is an abundant natural polysaccharide that contains a lot of amino and hydroxyl groups. It possesses great potential for biomedical applications owing to its low toxicity, biodegradability and low cost. Herein, a novel chitosan-based fluorescent copolymer (WS-CS-TPA) was designed and synthesized via nucleophilic substitution of hexachlorocyclotriphosphazene (HCCP), water-soluble chitosan (WS-CS) and an aggregation-induced emission (AIE) fluorogen (AIEgen) triphenylamine derivative (TPA-NH).
View Article and Find Full Text PDFUnlabelled: As the only standard of its kind, GB5009.35-2016 provides the determination of water-soluble synthetic colorants in processed grain products with high starch content for the purpose of food safety risk monitoring. However, it's only applicable to candy products and liquid foods as beverages, but not solid grain products.
View Article and Find Full Text PDFIn this work, a novel imidazoles-MXene hybrid composite, namely polyimidazoles chain overlaying on the surface of MXene (TiC@IMIZ), was prepared by a simple method. Through this strategy, imidazoles can be in situ growth on the surface of MXenes via a facile multicomponent reaction using chitosan as a renewable reactant. Based on the characterization results, we demonstrated that a thin layer imidazoles with an ordered chain structure was embedded on the surface of TiC, which resulted in the formation of a novel imidazoles-MXene hybrid composite.
View Article and Find Full Text PDFHalloysite nanotubes (HNTs) are a kind of aluminosilicate clay with a unique hollow tubular structure that has been intensively explored for various applications especially in biomedical fields owing to their excellent biocompatibility, biodegrading potential and low cost. Surface modification of HNTs with functional polymers will greatly improve their properties and endow new functions for biomedical applications. In this work, a light-induced reversible addition-fragmentation chain transfer (RAFT) polymerization was introduced to successfully prepare HNTs based fluorescent HNTs/poly(PEGMA-Fl) composites in the presence of oxygen using diacrylate-fluorescein and poly (ethylene glycol) methyl ether methacrylate (PEGMA) as the monomers.
View Article and Find Full Text PDFFluorescent hydroxyapatite (HAp) nanoparticles have received significant attention in biomedical fields due to their outstanding advantages, such as low immunogenicity, excellent biocompatibility and biodegradability. However, fluorescent HAp nanoparticles with well controlled size and morphology are coated with hydrophobic molecules and their biomedical applications are largely restricted by their poor dispersibility in physiological solutions. Therefore, surface modification of these hydrophobic fluorescent HAp nanoparticles to render them water dispersibility is of utmost importance for biomedical applications.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
January 2020
Fluorescent nanodiamond (ND) has been regarded as one of the most promising fluorescent nanoprobes owing to their chemical inert, biocompatibility, optical properties, and rich surface chemistry. The fluorescent ND has been mainly fabricated through high-energy ion beam irradiation of type Ib diamonds and subsequent thermal annealing. The generation of nitrogen-vacancy centers is the reason for the fluorescence.
View Article and Find Full Text PDFSurface modification of carbon nanotubes (CNTs) through controlled living polymerization has demonstrated to be a useful route for preparation of CNTs based polymer composites. However, surface oxidation of CNTs is often required to generate functional groups, which can be further utilized for immobilization of polymerization initiator and grafting polymers. The surface oxidation procedure is rather complex, high energy cost, low efficient and will destroy the structure of CNTs.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
November 2019
The preparation of fluorescent inorganic-organic polymer composites for biomedical applications has become one of the most interest research focuses recently. In this work, we reported a novel method for the preparation of Tb-doped luminescent layered double hydroxides (LDHs) based composites by taken advantage of a one-pot supramolecular chemistry. The adamantane can be immobilized on the surface of Tb-doped LDHs to obtain LDH-Ad, which could be further utilized for modified by the β-cyclodextrin (β-CD) containing hyperbranched polyglycerols (β-CD-HPG) through the host-guest interaction.
View Article and Find Full Text PDFFluorescent silica nanoparticles (FSNPs) have attracted great interest for potential applications in biological and biomedical fields because they possess higher fluorescence quantum yield and better fluorescence stability as comparison with small organic fluorescent molecules. The encapsulation of covalent linkage with fluorescent organic dyes or fluorescent metal complexes has demonstrated to be the commonly adopted strategies for fabrication of FSNPs previously. However, it is still challengeable to obtain FSNPs based polymer composites with intensive fluorescence and good water dispersibility through a one-pot surface modification strategy.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
December 2018
Silica quantum dots (SiQDs) and their luminescent composites have displayed great potential for biomedical applications owing to their chemical inert and low cost. In this work, we report a facile, cost-effective and ultrafast strategy to prepare a stable luminescent SiQDs using N-[3-(trimethoxysilyl)propyl]ethylenediamine (EDAS) and salicylaldehyde as precursors for the first time. These luminescent SiQDs were further utilized for fabrication of luminescent mesoporous silica nanoparticles (MSNs) through direct encapsulation of SiQDs by MSNs.
View Article and Find Full Text PDFA novel and facile strategy that combination of surface ligand exchange and photo-initiated atom transfer radical polymerization (ATRP) has been developed for the preparation of fluorescent hydroxyapatite (HAp) based polymer composites, which were utilized for biological imaging applications. In particular, the photo-initiated ATRP not only inherited advantages of traditional ATRP but also overcome its deficiencies such as high energy consumption, transition metal contamination and long reaction time. In this method, a hydrophilic and biocompatible PEGMA was introduced to enhance the hydrophilic and biocompatibility of HAp nanocomposites.
View Article and Find Full Text PDFTb-doped layered double hydroxides (LDHs) exhibit excellent optical characteristics, uniform size and uniform morphologies when synthesized through a hydrothermal method. However, due to their lack of functional groups and poor dispersibility, applications of these fluorescent Tb-doped LDHs have been largely impeded especially in the biomedical fields. In this work, a novel strategy was developed for the surface modification of these fluorescent Tb-doped LDHs using photoinduced surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization with hydrophilic poly(ethylene glycol) methacrylate (PEGMA) as the monomer.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
October 2018
Graphene quantum dots (GQDs), as a kind of carbon dots with the structure of graphene, possess fascinating properties of both carbon dots and graphene have attracted increasing attention for various applications especially in the biomedical fields. It is therefore, many methods for preparation of GQDs have been developed over the last decade. However, most of the previous reports are required tedious experimental procedure and hazardous agents.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
October 2018
Nanodiamond (ND) is one of the most fascinating carbon materials that have been extensively investigated for biomedical applications owing to its small size, high specific surface areas, chemical inert and desirable biocompatibility. It has been reported that surface modification of ND with polymers could not only improve the dispersibility of final ND based composites but also endow them novel functions to fulfill the requirement for biomedical applications. Although some strategies have been developed previously, surface modification of ND with poly(amino acid)s has not been reported previously.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
October 2018
Carbon nanotubes (CNTs) are novel carbon composites that have received extensive research attention for biomedical applications thanks to their excellent cell membrane penetration capability and large specific surface areas. Nevertheless, the poor dispersibility in aqueous solution still perplexes the biomedical applications of CNTs. Although, there are many researched about that modify hydrophilic polymers to the surface of CNTs, facile and efficient strategies are still highly desirable to be developed.
View Article and Find Full Text PDFLanthanide-doped nanoprobes have received significant attentions for utilization in biological sensing and imaging due to their unique optical properties. However, only few works were focused on fabrication of europium complexes based fluorescence polymeric nanoparticles (FPNs) with excellent biocompatibility and biodegradability. In this study, we fabricated the FPNs (named as Eu(TTA)Phen-GluEG FPNs) with encapsulated europium complexes which show low cytotoxicity, high sensitivity and deep penetration.
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