Roles of the components of the -pathogenicity island encoded type IV secretion system in .

The () cytotoxin-associated gene pathogenicity island (PAI) encodes 31 genes that assemble the type IV secretion system (T4SS) apparatus, which includes structures such as the outer membrane core complex, periplasmic ring, inner membrane complex and bacterial hairs. These proteins interact with each other to inject CagA into the host gastric epithelium. There are also individual unique functions that help interfere with host cellular pathways, modulate the immune response and colonize the host for a long time.

The efficacy of vonoprazan combined with different dose amoxicillin on eradication of : an open, multicenter, randomized clinical study.

Background: The use of vonoprazan (VPZ) has improved the () eradication therapy in Japan. There is no agreement on the dosage and frequency of amoxicillin administration in the VPZ dual treatment in China. We aimed to investigate the clinical effectiveness and safety of 3 treatment regimens using VPZ as an acid-suppressing medication to eradicate .

Antibiotics Resistance Prevalence of Strains in Northwest China.

Purpose: This study aims to estimate the resistance rate of () to commonly used antibiotics and analyze the potential influencing factors in northwest regions of China.

Patients And Methods: -positive patients visiting the outpatient department of multiple hospitals were enrolled in the study. Then, gastric mucosal biopsy specimens were collected for isolation, culture, and investigation of the resistance rate of to amoxicillin, metronidazole, tetracycline, levofloxacin, and clarithromycin by Epsilometer test (E-test) antibiotic susceptibility testing.

High-dose amoxicillin-proton pump inhibitor dual therapy as first-line treatment for Helicobacter pylori infection in Northwest China: A prospective, randomised controlled trial.

Aims: We aimed to assess the eradication efficacy and factors that influencing it of high-dose dual therapy (HDDT) in Gansu region, Northwest China.

Methods: A total of 216 treatment-naive patients with Helicobacter pylori infection were randomly assigned to two groups for the 14-day eradication treatment: the HDDT group (amoxicillin 750 mg q.i.

The high-dose amoxicillin-proton pump inhibitor dual therapy in eradication of infection.

Introduction: More attention has been paid to the eradication therapy of with the enhancement of health awareness of patients. However, the increasing antibiotic resistance of , due to the wide use and abuse of antibiotics, has become a critical factor affecting the efficacy of eradication. To effectively improve the eradication rate of , high-dose amoxicillin-proton pump inhibitor (PPI) dual therapy has recently become one of the hot issues.