The protective mechanism of protein kinase R to inhibit neuronal ferroptosis in cerebral injury from subarachnoid hemorrhage.

Purpose: To investigate the role and mechanism of protein kinase R (PKR) in subarachnoid hemorrhage (SAH)-mediated ferroptosis.

Methods: A rat SAH model was constructed and treated with PKR inhibitor C16 to observe SAH and neurological impairment in rats and to detect malonaldehyde (MDA), iron ions content, ferritin heavy polypeptide 1 (FTH1) and glutathione peroxidase 4 (GPX4), and other related ferroptosis indicators in brain tissue. RNA sequencing analysis was used to investigate the mechanism of PKR, affecting the ferroptosis network of SAH.

Hispidulin Enhances Temozolomide (TMZ)-Induced Cytotoxicity against Malignant Glioma Cells by Inhibiting Autophagy.

Temozolomide (TMZ), an oral alkylating agent, is the widely used first-line chemotherapeutic reagent for glioma in clinical practice. However, TMZ-induced autophagy is another cellular process favoring glioma cell survival. This study aimed to explore whether hispidulin can facilitate TMZ-induced cell death of glioma.

Development and Multi-Data Set Verification of an RNA Binding Protein Signature for Prognosis Prediction in Glioma.

Increasing evidence emphasizes the clinical implications of RNA binding proteins (RBPs) in cancers. This study aimed to develop a RBP signature for predicting prognosis in glioma. Two glioma datasets as training ( = 693) and validation ( = 325) sets were retrieved from the CGGA database.

Insight Into the Role of Ferroptosis in Non-neoplastic Neurological Diseases.

Ferroptosis is an iron-dependent form of cell death characterized by the accumulation of intracellular lipid reactive oxygen species (ROS). Ferroptosis is significantly different from other types of cell death including apoptosis, autophagy, and necrosis, both in morphology and biochemical characteristics. The mechanisms that are associated with ferroptosis include iron metabolism, lipid oxidation, and other pathophysiological changes.

Hydrogen sulfide ameliorates subarachnoid hemorrhage-induced neuronal apoptosis the ROS-MST1 pathway.

Background: Hydrogen sulfide (HS) has shown a neuroprotective role in several cerebrovascular diseases. This study aimed to explore the underlying mechanisms of HS in early brain injury after subarachnoid hemorrhage (SAH).

Methods: One hundred seventy-seven male Sprague-Dawley rats were employed in this study.