Knowledge graph construction based on granulosa cells transcriptome from polycystic ovary syndrome with normoandrogen and hyperandrogen.

PCOS is a widespread disease that primarily caused in-pregnancy in pregnant-age women. Normoandrogen (NA) and Hyperandrogen (HA) PCOS are distinct subtypes of PCOS, while bio-markers and expression patterns for NA PCOS and HA PCOS have not been disclosed. We performed microarray analysis on granusola cells from NA PCOS, HA PCOS and normal tissue from 12 individuals.

MYSM1 acts as a novel co-activator of ERα to confer antiestrogen resistance in breast cancer.

Endocrine resistance is a crucial challenge in estrogen receptor alpha (ERα)-positive breast cancer (BCa). Aberrant alteration in modulation of E2/ERα signaling pathway has emerged as the putative contributor for endocrine resistance in BCa. Herein, we demonstrate that MYSM1 as a deubiquitinase participates in modulating ERα action via histone and non-histone deubiquitination.

Microstructural Evolution of Diamond-Based Composites at High Temperature and High Pressure.

Improving the toughness of diamond composites has become an industrial demand. In this work, CoNiFe multi-element alloy was designed as binder for diamond-based composites prepared by high temperature and high pressure (HTHP). Two methods of mixing-sintering and infiltration-sintering were used to prepare diamond-based composites with different diamond contents.

Histone modification and histone modification-targeted anti-cancer drugs in breast cancer: Fundamentals and beyond.

Dysregulated epigenetic enzymes and resultant abnormal epigenetic modifications (EMs) have been suggested to be closely related to tumor occurrence and progression. Histone modifications (HMs) can assist in maintaining genome stability, DNA repair, transcription, and chromatin modulation within breast cancer (BC) cells. In addition, HMs are reversible, dynamic processes involving the associations of different enzymes with molecular compounds.

Identification and structural analysis of a thermophilic β-1,3-glucanase from compost.

β-1,3-glucanase can specifically hydrolyze glucans to oligosaccharides and has potential applications in biotechnology. We used the metatranscriptomic technology to discover a thermophilic β-1,3-glucanase from compost. The phylogenetic study shows that it belongs to the family 16 glycoside hydrolase (GH16) and is most homologous with an enzyme from Streptomyces sioyaensis, an actinobacterium.

Parameter Determination and Ion Current Improvement of the Ion Current Sensor Used for Flame Monitoring.

Flame monitoring of industrial combustors with high-reliability sensors is essential to operation security and performance. An ion current flame sensor with a simple structure has great potential to be widely used, but a weak ion current is the critical defect to its reliability. In this study, parameters of the ion current sensor used for monitoring flames on a Bunsen burner are suggested, and a method of further improving the ion current is proposed.

Enhanced electrochemical and capacitive deionization performance of metal organic framework/holey graphene composite electrodes.

In this paper, we designed and prepared a novel metal organic framework (MOF)/holey graphene (HG) composites as electrode materials for electrochemistry and capacitive deionization (CDI). The MOF nanoparticles were attached to the surface of the HG sheets to form layered porous structure, which promoted the transport of ions and electrons in the electrode/electrolyte interfaces. Additionally, the synergistic effect of these composite electrodes, which combined pseudocapacitance performance of MOF and the high conductivity of graphene, contributed to enhancing the performance of electrochemistry and CDI.

An improved geomechanical model for the prediction of fracture generation and distribution in brittle reservoirs.

It is generally difficult to predict fractures of low-permeability reservoirs under high confining pressures by data statistical method and simplified strain energy density method. In order to establish a series of geomechanical models for the prediction of multi-scale fractures in brittle tight sandstones, firstly, through a series of rock mechanics experiments and CT scanning, we determined 0.85 σc as the key thresholds for mass release of elastic strain energy and bursting of micro-fractures.

[Spatial distribution of three endocrine disrupting chemicals in sediments of the Suzhou Creek and their environmental risks].

Three environmental endocrine disrupting chemicals (EDCs), named nonylphenol (NP), octylphenol (4-t-OP) and bisphenol A (BPA), in sediments of the Suzhou Creek and its branches were detected using gas chromatography-mass spectrometry (GC-MS) method. The results showed that the concentration of three chemicals varied greatly from site to site, which ranged from < 1.0-5 800, < 0.

Cardiac sequelae in Brooklyn after the September 11 terrorist attacks.

Background: Terrorism, such as the attacks on the World Trade Center (WTC) on September 11, 2001, result in higher stress-related disorders, especially in those persons in close proximity.

Hypothesis: Cardiac events resulting from the September 11, 2001 tragedy have not been detailed near the WTC.

Methods: Patients admitted to the Telemetry and Coronary Care Units at New York Methodist Hospital 4 miles from the WTC 60 days prior to and after the September 11 attacks were analyzed.