3D orthogonal woven composites are receiving increasing attention with the ever-growing market of composites. A current challenge for these materials' development is how to improve their damage tolerance in orthogonal and layer-to-layer structures under extreme loads. In this paper, a damage reduction strategy is proposed by combining structural and electromagnetic properties.
View Article and Find Full Text PDFEthnopharmacological Relevance: Chinese herbal medicine (CHM) draws more attention to explore effective therapeutic strategy for Alzheimer's disease (AD). CHM usually uses combinations of herbs or herbal ingredients to treat diseases, with the components targeting different disease processes. CHM might improve cognition in AD and MCI patients by optimizing network activity, promoting neural plasticity and repairing damaged neurons.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by the cognitive impairments. It is essential to identify potential gene biomarkers for AD pathology.
Methods: DNA methylation expression data of patients with AD were downloaded from the Gene Expression Omnibus (GEO) database.
Micromachines (Basel)
October 2019
The nonlinear coupled vibration of an electrically actuated arch microbeam has attracted wide attention. In this paper, we studied the nonlinear dynamics of an electrically actuated arch microbeam with flexible supports. The two-to-one internal resonance between the first and second modes is considered.
View Article and Find Full Text PDFWe present an investigation of the nonlinear dynamics of a microelectromechanical system (MEMS) arch subjected to a combination of AC and DC loadings in the presence of three-to-one internal resonance. The axial force resulting from the residual stress or temperature variation is considered in the governing equation of motion. The method of multiple scales is used to solve the governing equation.
View Article and Find Full Text PDFDicaffeoylquinic acids (DCQAs) are widely distributed in daily food and herb medicine (such as Dengzhanxiyin injection) with multiple health benefits and pharmacological activities. However, drug-drug Interactions (DDIs) between DCQAs and possible concomitant drugs were not fully understood in clinic. The purpose of present study was to investigate the role of organic anion transporters (OATs) in the transport of DCQAs and to explore the potential clinical DDIs using in vitro transporter assays.
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