Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from sp. MS751.

A new dimeric C-glycoside polyketide chrysomycin F (), along with four new monomeric compounds, chrysomycins G (), H (), I (), J (), as well as three known analogues, chrysomycins A (), B (), and C (), were isolated and characterised from a strain of sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis.

Histone H1 facilitates restoration of H3K27me3 during DNA replication by chromatin compaction.

During cell renewal, epigenetic information needs to be precisely restored to maintain cell identity and genome integrity following DNA replication. The histone mark H3K27me3 is essential for the formation of facultative heterochromatin and the repression of developmental genes in embryonic stem cells. However, how the restoration of H3K27me3 is precisely achieved following DNA replication is still poorly understood.

Unique Cyclized Thiolopyrrolones from the Marine-Derived sp. BTBU20218885.

Two new cyclized thiolopyrrolone derivatives, namely, thiolopyrrolone A () and 2,2-dioxidothiolutin (), together with the kn own compound, thiolutin () were identified from a marine-derived sp. BTBU20218885, which was isolated from a mud sample collected from the coastal region of Xiamen, China. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D and 2D NMR techniques.

Antitubercular metabolites from the marine-derived fungus strain MF029.

During the systematic screening of bioactive compounds from our marine natural product library, crude extract of the marine-derived fungus strain MF029 exhibited moderate bioactivities against , S, methicillin-resistant , and bacillus Calmette-Guérin (BCG). Further chemical investigation resulted in the identification of two new compounds, chaetominine A () and sphingofungin I (), together with four known compounds, emodin (), chaetominine (), sphingofungin D () and trypacidin (). Trypacidin displayed potential antitubercular activity with MIC value of 1.

Chaetoglobosins and azaphilones from Chaetomium globosum associated with Apostichopus japonicus.

Increasing attention has recently been focused on complex symbiotic associations, for instance coral and its symbionts. Sea cucumber, harboring diverse fungi, has also attracted more and more attention for their functional diversity. Here, secondary metabolites produced by Chaetomium globosum associated with sea cucumber, Apostichopus japonicus, were investigated using gene mining with third-generation sequencing technology (PacBio SMRT).

New Diketopiperazines from a Marine-Derived Fungus Strain MF180151.

Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)-), (±)-8-hydroxy-brevianamide R ((±)-), and (±)-8-epihydroxy-brevianamide R ((±)-), together with four known compounds, (±)-brevianamide R ((±)-), versicolorin B () and averufin (), were isolated from a marine-derived fungus strain MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. is the first sample of brevianamides with an epoxy moiety.

One new xanthenone from the marine-derived fungus MF160003.

A new xanthenone derivative, 3-hydroxy pinselin (), together with five known analogues () were isolated from the marine-derived fungus MF160003. Their structures were identified by extensive 1D- and 2D-NMR, and high-resolution mass spectrometry data. Compounds and showed moderate bioactivities against BCG with MIC values of 40 and 20 μg/mL, respectively.

Lichen elemental composition distinguishes anthropogenic emissions from dust storm inputs and differs among species: Evidence from Xilinhot, Inner Mongolia, China.

To test the applicability of lichens in the biomonitoring of atmospheric elemental deposition in a typical steppe zone of Inner Mongolia, China, six foliose lichens (Physcia aipolia, PA; P. tribacia, PT; Xanthoria elegans, XE; X. mandschurica, XM; Xanthoparmelia camtschadalis, XPC; and Xp.

Use of the lichen Xanthoria mandschurica in monitoring atmospheric elemental deposition in the Taihang Mountains, Hebei, China.

Air pollution is a major concern in China. Lichens are a useful biomonitor for atmospheric elemental deposition but have rarely been used in North China. The aim of this study was to investigate the atmospheric depositions of 30 trace elements (Al, Ba, Ca, Cd, Ce, Co, Cr, Cs, Cu, Fe, K, La, Mg, Mn, Mo, Na, Ni, P, Pb, Rb, Sb, Sc, Sm, Sr, Tb, Th, Ti, Tl, V and Zn) in a region of the Taihang Mountains, Hebei Province, China using lichens as biomonitors.