Luminescent cyclometalated gold(iii) complexes covalently linked to metal-organic frameworks for heterogeneous photocatalysis.

Phosphorescent gold(iii) complexes possess long-lived emissive excited states, making them ideal for use as molecular sensors and photosensitizers for organic transformations. Literature reports indicate that gold(iii) emitters exhibit good catalytic activity in homogeneous photochemical reactions. Heterogeneous metal-organic framework (MOF)-supported gold(iii) photocatalysts are considered to show high recyclability in photochemical reactions and potentially provide new selectivities.

The underlying mechanism and therapeutic potential of IFNs in viral-associated cancers.

Interferons (IFNs) are a diverse family of cytokines secreted by various cells, including immune cells, fibroblasts, and certain viral-parasitic cells. They are classified into three types and encompass 21 subtypes based on their sources and properties. The regulatory functions of IFNs closely involve cell surface receptors and several signal transduction pathways.

Hypergraph contrastive attention networks for hyperedge prediction with negative samples evaluation.

Hyperedge prediction aims to predict common relations among multiple nodes that will occur in the future or remain undiscovered in the current hypergraph. It is traditionally modeled as a classification task, which performs hypergraph feature learning and classifies the target samples as either present or absent. However, these approaches involve two issues: (i) in hyperedge feature learning, they fail to measure the influence of nodes on the hyperedges that include them and the neighboring hyperedges, and (ii) in the binary classification task, the quality of the generated negative samples directly impacts the prediction results.

Exosomes derived from bone marrow mesenchymal stem cells induce the proliferation and osteogenic differentiation and regulate the inflammatory state in osteomyelitis in vitro model.

Chronic osteomyelitis is a chronic bone infection characterized by progressive osteonecrosis and dead bone formation, which is closely related to persistent infection and chronic inflammation. Exosomes derived from bone marrow-derived mesenchymal stem cells (BMSC) play an important role in bone tissue regeneration and the modulation of inflammatory processes. However, their role and mechanism of action in osteomyelitis have not been reported so far.

Roles of Integrin in Cardiovascular Diseases: From Basic Research to Clinical Implications.

Cardiovascular diseases (CVDs) pose a significant global health threat due to their complex pathogenesis and high incidence, imposing a substantial burden on global healthcare systems. Integrins, a group of heterodimers consisting of α and β subunits that are located on the cell membrane, have emerged as key players in mediating the occurrence and progression of CVDs by regulating the physiological activities of endothelial cells, vascular smooth muscle cells, platelets, fibroblasts, cardiomyocytes, and various immune cells. The crucial role of integrins in the progression of CVDs has valuable implications for targeted therapies.

Higher-order neurodynamical equation for simplex prediction.

It is demonstrated that higher-order patterns beyond pairwise relations can significantly enhance the learning capability of existing graph-based models, and simplex is one of the primary form for graphically representing higher-order patterns. Predicting unknown (disappeared) simplices in real-world complex networks can provide us with deeper insights, thereby assisting us in making better decisions. Nevertheless, previous efforts to predict simplices suffer from two issues: (i) they mainly focus on 2- or 3-simplices, and there are few models available for predicting simplices of arbitrary orders, and (ii) they lack the ability to analyze and learn the features of simplices from the perspective of dynamics.

HoRDA: Learning higher-order structure information for predicting RNA-disease associations.

CircRNA and miRNA are crucial non-coding RNAs, which are associated with biological diseases. Exploring the associations between RNAs and diseases often requires a significant time and financial investments, which has been greatly alleviated and improved with the application of deep learning methods in bioinformatics. However, existing methods often fail to achieve higher accuracy and cannot be universal between multiple RNAs.

The role of KLF transcription factor in the regulation of cancer progression.

Kruppel-like factors (KLFs) are a family of zinc finger transcription factors that have been found to play an essential role in the development of various human tissues, including epithelial, teeth, and nerves. In addition to regulating normal physiological processes, KLFs have been implicated in promoting the onset of several cancers, such as gastric cancer, lung cancer, breast cancer, liver cancer, and colon cancer. To inhibit cancer progression, various existing medicines have been used to modulate the expression of KLFs, and anti-microRNA treatments have also emerged as a potential strategy for many cancers.

The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology.

Integrins are a group of heterodimers consisting of α and β subunits that mediate a variety of physiological activities of immune cells, including cell migration, adhesion, proliferation, survival, and immunotolerance. Multiple types of integrins act differently on the same immune cells, while the same integrin may exert various effects on different immune cells. In the development of cancer, integrins are involved in the regulation of cancer cell proliferation, invasion, migration, and angiogenesis; conversely, integrins promote immune cell aggregation to mediate the elimination of tumors.

Building a cobaloxime-based metal-organic framework for photocatalytic aerobic oxidation of arylboronic acids to phenols.

Herein, the design and synthesis of an unprecedented cobaloxime-based zirconium metal-organic framework (Zr-TCPCo) with an net is reported. This heterogeneous material as a photocatalyst exhibits excellent catalytic activity for aerobic oxidation of arylboronic acids to phenols. Recycling experiments demonstrate the stability and reusability of Zr-TCPCo as a robust catalyst.

Efficient Asynchronous Federated Learning for AUV Swarm.

The development of automatic underwater vehicles (AUVs) has brought about unprecedented profits and opportunities. In order to discover the hidden valuable data detected by an AUV swarm, it is necessary to aggregate the data detected by AUV swarm to generate a powerful machine learning model. Traditional centralized machine learning generates a large number of data exchanges and faces problems of enormous training data, large-scale models, and communication.

Stable Tetradentate Gold(III)-TADF Emitters with Close to Unity Quantum Yield and Radiative Decay Rate Constant of up to 2 × 10 s : High-Efficiency Green OLEDs with Operational Lifetime (LT ) Longer than 1800 h at 1000 cd m.

High maximum external quantum efficiency (EQE ), small efficiency roll-offs, and long operational lifetime at practical luminances are three crucial parameters for commercialization of organic light-emitting diodes (OLEDs). To simultaneously achieve these goals, it is desirable to have the radiative decay rate constant (k ) as large as possible, which, for a thermally activated delayed fluorescent (TADF) emitter, requires both a large S →S radiative decay rate constant (k ) and a small singlet-triplet energy gap (ΔE ). Here, the design of a class of tetradentate gold(III) TADF complexes for narrowing the ΔE while keeping the k large is reported.

Integrin-mediated cancer progression as a specific target in clinical therapy.

Integrins, a group of heterodimer receptors for cell-matrix and cell-cell adhesion, mediate various intracellular activities, including cell migration, polarity, survival, growth, and death. Multiple types of integrins are differentially expressed in various cancers during different stages of progression, which are involved in the regulation of cancer cell proliferation, invasion, migration, and angiogenesis. The crucial roles of integrins in tumor progression provide valuable clues for cancer diagnosis and targeted therapy.

Ligand Tailoring Strategy of a Metal-Organic Framework for Optimizing Methane Storage Working Capacities.

Methane, as the main component of natural gas, shale gas, and marsh gas, is regarded as an ideal clean energy to replace traditional fossil fuels and reduce carbon emissions. Porous materials with superior methane storage capacities are the key to the wide application of adsorbed natural gas technology in vehicle transportation. In this work, we applied a ligand tailoring strategy to a metal-organic framework (NOTT-101) to fine-tune its pore geometry, which was well characterized by gas and dye sorption measurements.