Enhancing diabetic wound healing with a pH/glucose dual-responsive hydrogel for ROS clearance and antibacterial activity.

Currently, the treatment of diabetic wounds in clinical practice is still unsatisfactory due to the risks of oxidative damage and bacterial infection during the healing process. An optimal wound dressing should exhibit robust capabilities in scavenging reactive oxygen species (ROS) and combatting bacterial growth. In this study, we utilized borax as a crosslinker and prepared a pH/glucose dual-responsive composite hydrogel based on poly(vinyl alcohol) (PVA), sodium alginate (SA), and tannic acid (TA).

Sr-Stabilized IrMnO Solid Solution Nano-Electrocatalysts with Superior Activity and Excellent Durability for Oxygen Evolution Reaction in Acid Media.

The development of cost-effective catalysts for oxygen evolution reaction (OER) in acidic media is of paramount importance. This work reports that Sr-doped solid solution structural ultrafine IrMnO nanoparticles (NPs) (≈1.56 nm) on the carbon nanotubes (Sr-IrMnO/CNTs) are efficient catalysts for the acidic OER.

Achieving High Activity and Long-Term Stability towards Oxygen Evolution in Acid by Phase Coupling between CeO-Ir.

The development of efficient and stable catalysts with high mass activity is crucial for acidic oxygen evolution reaction (OER). In this study, CeO-Ir heterojunctions supported on carbon nanotubes (CeO-Ir/CNTs) are synthesized using a solvothermal method based on the heterostructure strategy. CeO-Ir/CNTs demonstrate remarkable effectiveness as catalysts for acidic OER, achieving 10.

Dapper1 attenuates hepatic gluconeogenesis and lipogenesis by activating PI3K/Akt signaling.

Studies have shown that hepatic insulin resistance, a disorder of glucose and lipid metabolism, plays a vital role in type 2 diabetes (T2D). To clarify the function of Dapper1 in glucose and lipid metabolism in the liver, we investigated the relationships between Dapper1 and adenosine triphosphate (ATP)- and Ca-mediated activation of PI3K/Akt. We observed a reduction in hepatic Dapper1 in db/db (mice that are homozygous for a spontaneous diabetes mutation) and HFD-induced diabetic mice with T2D.