Construction of prediction model of early glottic cancer based on machine learning.

Background: The early diagnosis of glottic laryngeal cancer is the key to successful treatment, and machine learning (ML) combined with narrow-band imaging (NBI) laryngoscopy provides a new idea for the early diagnosis of glottic laryngeal cancer.

Objective: To explore the clinical applicability of the diagnosis of early glottic cancer based on ML combined with NBI.

Material And Methods: A retrospective study was conducted on 200 patients diagnosed with laryngeal mass, and the general clinical characteristics and pathological results of the patients were collected.

Effect of Smoking on Cepstral Parameters.

Smoking exerts certain damage to the voice, which affects sound characteristics. This study explored the effects of smoking, smoking time, and smoking amount on cepstral parameters. We collected the acoustic signals of sustained vowels in 301 participants (135 smokers and 166 nonsmokers).

[Detection of speech pathology based on parameters of analysis of dysphonia in speech and voice].

To analysis speech pathology based on dysphonia in speech and voice（ADSV）. The acoustic signals of continuous vowels and continuous speech of one-hundred and thirteen individuals were collected, including 93 vocal cord polyps cases, 20 glottis laryngeal carcinoma cases and 47 volunteers without speech sound disorders. Cepstral peak prominence（CPP）, CPP standard deviation（CPP SD）, L/H spectral ratio（L/H ratio）, L/H ratio standard deviation（L/H ratio SD） and cepstral/spectral index of dysphonia（CSID） were analyzed by ADSV to explore the role of these parameters in the recognition of speech pathology.

Voice disorders in severe obstructive sleep apnea patients and comparison of two acoustic analysis software programs: MDVP and Praat.

Objective: The purposes of this study were to explore the effect of obstructive sleep apnea-hypopnea syndrome (OSAHS) on the voice by analyzing the acoustic parameters between patients with OSAHS and those without OSAHS and to compare acoustic analyses performed by two software programs (MDVP and Praat).

Methods: Patients with OSAHS (n = 75) and normal controls (n = 46) were asked to produce a sustained sound of the vowel /i/ and were analyzed with electroglottography (EGG), MDVP, and Praat software. A self-rated scale (Voice Handicap Index, VHI-10) and acoustic parameters were compared.

Research of UL54-specific siRNA on herpes simplex virus type II replication.

To determine how UL54-specific siRNA affects virus replication and protection of host cells, we examined virus titer and the activity of the cells at 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours after process of RNAi, including: four UL54-specific siRNAs and the positive/negative control siRNAs synthesized in vitro by chemical processes. The Vero cells were transfected with siRNAs using lipofectamine 2000 followed by infection by HSV-II. Our studies reveal that the groups with UL54-specific siRNA decreased significantly in virus titer at 12-24 hours, and only slightly decreased after that; groups with UL54-specific siRNA had higher OD values shown by MTT colorimetric assay than blank cells and survived better; R2 and R4 groups had lower virus titer and better survival than other groups.

[Oncologic outcome of carbon dioxide laser microsurgery for early glottic carcinoma].

Objective: To explore the oncologic efficacy of transoral endoscopic CO2 laser surgery in early glottic carcinoma.

Method: Retrospectively study 91 patients with glottic carcinoma (9 Tis, 45 pT1a, 25 pT1b, 12 pT2) treated in our department from October 1999 to August 2004. Surgical treatment included endoscopic CO2 laser cordectomies according to the classification of the European Laryngological Society in 2000.

[Aerodynamic study of the low-resistance Groningen button in voice prosthesis].

Objective: To study the aerodynamic characteristics of low-resistance Groningen voice prosthesis for total laryngectomees and the related clinical significance.

Methods: Three aerodynamic parameters were measured in 24 laryngectomees implanted with low-resistance Groningen voice prosthesis: the sound pressure level (SPL), intratracheal pressure (pressure) and airflow rate (flowrate). Among them, 6 cases were initially implanted with other prosthesis which was replaced by the Groningen buttons later.

[Diagnosis and treatment and prevention of iatrogenic functional aphonia].

Objective: To discuss the diagnosis, treatment and prevention of iatrogenic functional aphonia.

Methods: Twenty three patients who either lost their voice or only could whisper after surgery in other hospitals were included in this study as the first group, history was well collected and laryngostroboscopy performed. All cases were confirmed as iatrogenic functional aphonia patients and received phonation therapy.